CRCGN014_HEPG2_3H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-2-[4-(dimethylamino)phenyl]diazenesulfonate 21.71 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN014_HEPG2_3H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 4.57079
GPER1 G protein-coupled estrogen receptor 1 3.60959
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.60476
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.11967
LCN2 lipocalin 2 2.86681
GSTZ1 glutathione S-transferase zeta 1 2.78985
UBQLN2 ubiquilin 2 2.74368
NOSIP nitric oxide synthase interacting protein 2.6926
LOC122526780 uncharacterized LOC122526780 2.5264
ILK integrin-linked kinase 2.43301
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.41699
HLA-DRA major histocompatibility complex, class II, DR alpha 2.40975
USP6NL USP6 N-terminal like 2.32158
TIAM1 T-cell lymphoma invasion and metastasis 1 2.30796
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.23422
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 2.09124
EVL Enah/Vasp-like 2.08844
TATDN2 TatD DNase domain containing 2 2.05898
PIH1D1 PIH1 domain containing 1 2.01595

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.6884
ZNF586 zinc finger protein 586 -5.30408
NGRN neugrin, neurite outgrowth associated -4.03565
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.57332
NVL nuclear VCP-like -3.54109
TBC1D31 TBC1 domain family, member 31 -3.24477
PEG10 paternally expressed 10 -3.20175
CDC20 cell division cycle 20 -3.17873
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.97493
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.95066
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.91828
MAPK13 mitogen-activated protein kinase 13 -2.57846
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.55705
GRB7 growth factor receptor-bound protein 7 -2.50433
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.38273
OXA1L oxidase (cytochrome c) assembly 1-like -2.37446
TLR4 toll-like receptor 4 -2.36554
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.27293
BPHL biphenyl hydrolase-like (serine hydrolase) -2.21519
LDHD lactate dehydrogenase D -2.15856
FAAP20 FA core complex associated protein 20 -2.02093
DDIT4 DNA-damage-inducible transcript 4 -2.01325