CRCGN014_HEPG2_3H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumarin 40.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN014_HEPG2_3H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.99931
GPER1 G protein-coupled estrogen receptor 1 5.70904
EPHB2 EPH receptor B2 5.33519
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.26337
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.1475
LCN2 lipocalin 2 4.66275
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.11607
NOTCH1 notch 1 3.9312
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.6594
TAC4 tachykinin 4 (hemokinin) 3.60971
DHDDS dehydrodolichyl diphosphate synthase 3.19809
LOC107985101 uncharacterized LOC107985101 3.15115
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.91114
MELK maternal embryonic leucine zipper kinase 2.82459
SNAP25 synaptosomal-associated protein, 25kDa 2.67357
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.65575
LEP leptin 2.63183
CNPY3 canopy FGF signaling regulator 3 2.62931
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.57704
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.53881
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.50312
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 2.49691
SMIM40 small integral membrane protein 40 2.47939
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.46125
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.45597
HBA1 hemoglobin, alpha 1 2.43734
LOC122526780 uncharacterized LOC122526780 2.39533
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.38888
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.35591
EGF epidermal growth factor 2.35279
PNKP polynucleotide kinase 3'-phosphatase 2.34748
AMDHD2 amidohydrolase domain containing 2 2.33528
DENND4C DENN/MADD domain containing 4C 2.3273
EID1 EP300 interacting inhibitor of differentiation 1 2.27511
CASZ1 castor zinc finger 1 2.27463
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.25337
MMP2 matrix metallopeptidase 2 2.20892
TNMD tenomodulin 2.20842
IQSEC3 IQ motif and Sec7 domain 3 2.20732
AQP7 aquaporin 7 2.20195
ZIC3 Zic family member 3 2.18161
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.16665
TXNL4B thioredoxin-like 4B 2.15373
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.15082
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.14184
PARD6A par-6 family cell polarity regulator alpha 2.12258
SFTPB surfactant protein B 2.10469
CPLX3 complexin 3 2.10231
CCN5 cellular communication network factor 5 2.09131
JADE2 jade family PHD finger 2 2.09108
CA4 carbonic anhydrase IV 2.08206
HUNK hormonally up-regulated Neu-associated kinase 2.07833
FZD7 frizzled class receptor 7 2.02183
ODAD2 outer dynein arm docking complex subunit 2 2.01968
ATG10 autophagy related 10 2.01226
SIRT3 sirtuin 3 2.00168
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.00102

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -5.78073
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.05954
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.91437
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.79034
MRPS2 mitochondrial ribosomal protein S2 -4.4181
VAT1 vesicle amine transport 1 -2.66281
FGFR4 fibroblast growth factor receptor 4 -2.34114
RPIA ribose 5-phosphate isomerase A -2.33283
THAP11 THAP domain containing 11 -2.28685
CSK c-src tyrosine kinase -2.2705
EIF5 eukaryotic translation initiation factor 5 -2.24458
CCNB2 cyclin B2 -2.18468
NGRN neugrin, neurite outgrowth associated -2.15556
TM9SF2 transmembrane 9 superfamily member 2 -2.14399
TPST1 tyrosylprotein sulfotransferase 1 -2.11323
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.05619
ARID5B AT rich interactive domain 5B (MRF1-like) -2.05364
PLAC8 placenta-specific 8 -2.00331