CRCGN014_HEPG2_3H:B10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyleugenol 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN014_HEPG2_3H:B10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 8.79127
ADRB2 adrenoceptor beta 2, surface 5.39023
CBR3 carbonyl reductase 3 5.2023
STIMATE STIM activating enhancer 5.06358
NOTCH1 notch 1 5.04068
BACE2 beta-site APP-cleaving enzyme 2 4.83838
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.81985
ANO1 anoctamin 1, calcium activated chloride channel 4.49048
DIPK1A divergent protein kinase domain 1A 4.19881
KDM5A lysine (K)-specific demethylase 5A 4.18085
JADE2 jade family PHD finger 2 3.7003
MEST mesoderm specific transcript 3.3989
SHB Src homology 2 domain containing adaptor protein B 3.22873
UBQLN2 ubiquilin 2 3.1554
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.73574
SATB1 SATB homeobox 1 2.55803
ATP11B ATPase, class VI, type 11B 2.41585
EFCAB14 EF-hand calcium binding domain 14 2.40095
C5 complement component 5 2.26728
INTS3 integrator complex subunit 3 2.12296
KIF20A kinesin family member 20A 2.09903
FOXM1 forkhead box M1 2.09886
EFNA1 ephrin-A1 2.08119
CXCL2 chemokine (C-X-C motif) ligand 2 2.03158

decreased expression

Symbol Name Standardized Value
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.74382
UGDH UDP-glucose 6-dehydrogenase -5.36568
MRPS2 mitochondrial ribosomal protein S2 -5.25404
FAIM Fas apoptotic inhibitory molecule -4.58179
CD320 CD320 molecule -4.35977
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.35677
ZNF586 zinc finger protein 586 -4.14092
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.03926
CCNB2 cyclin B2 -3.89126
WASHC4 WASH complex subunit 4 -2.84596
ETFB electron-transfer-flavoprotein, beta polypeptide -2.73167
NRIP1 nuclear receptor interacting protein 1 -2.60289
PARP2 poly (ADP-ribose) polymerase 2 -2.54822
PWP1 PWP1 homolog (S. cerevisiae) -2.47287
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.40644
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.3484
GNAS GNAS complex locus -2.26566
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.23783
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.17643
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.1266
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.03578