CRCGN014_HEPG2_3H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-nitrosodiphenylamine 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN014_HEPG2_3H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 10.0
BAG3 BCL2-associated athanogene 3 6.88874
MAP7 microtubule-associated protein 7 5.71009
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 5.04342
EGR1 early growth response 1 4.81606
HSPA1B heat shock 70kDa protein 1B 4.39237
HMOX1 heme oxygenase 1 4.06132
EAPP E2F-associated phosphoprotein 4.03779
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.89305
CGRRF1 cell growth regulator with ring finger domain 1 3.74649
ABHD4 abhydrolase domain containing 4 3.63396
GPATCH8 G patch domain containing 8 3.52188
ADRB2 adrenoceptor beta 2, surface 3.40381
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.25873
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.1639
CIAO3 cytosolic iron-sulfur assembly component 3 3.16213
FRS2 fibroblast growth factor receptor substrate 2 3.14168
MAMLD1 mastermind-like domain containing 1 3.08797
UBQLN2 ubiquilin 2 3.06578
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.06544
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.99558
LCN2 lipocalin 2 2.92329
JMJD6 jumonji domain containing 6 2.81505
INPP1 inositol polyphosphate-1-phosphatase 2.67426
STIMATE STIM activating enhancer 2.6702
PLSCR1 phospholipid scramblase 1 2.66251
SAA2 serum amyloid A2 2.6333
LPAR2 lysophosphatidic acid receptor 2 2.60222
FOSL1 FOS-like antigen 1 2.57246
MRPL18 mitochondrial ribosomal protein L18 2.54487
PTK2 protein tyrosine kinase 2 2.48111
TBCC tubulin folding cofactor C 2.43424
CCL2 chemokine (C-C motif) ligand 2 2.41999
DDIT4 DNA-damage-inducible transcript 4 2.41571
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.39615
SSBP2 single-stranded DNA binding protein 2 2.3683
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.34831
CDPF1 cysteine-rich, DPF motif domain containing 1 2.33427
BANF1 barrier to autointegration factor 1 2.3164
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.28688
ATG101 autophagy related 101 2.27757
CHN1 chimerin 1 2.26191
TMSB10 thymosin beta 10 2.21556
GSTZ1 glutathione S-transferase zeta 1 2.15607
TOB2 transducer of ERBB2, 2 2.15126
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.12658
CTNND2 catenin (cadherin-associated protein), delta 2 2.12476
MYNN myoneurin 2.12115
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.1
IRX5 iroquois homeobox 5 2.09573
KDM5A lysine (K)-specific demethylase 5A 2.08247
LTB lymphotoxin beta (TNF superfamily, member 3) 2.05908
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.02917
ATG14 autophagy related 14 2.02417
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.02139
DRC9 dynein regulatory complex subunit 9 2.01184
ZFP36 ZFP36 ring finger protein 2.00533
SCYL3 SCY1-like 3 (S. cerevisiae) 2.00446

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.25802
COG7 component of oligomeric golgi complex 7 -4.79712
SLC35F2 solute carrier family 35, member F2 -4.62956
DERA deoxyribose-phosphate aldolase (putative) -4.36826
NRIP1 nuclear receptor interacting protein 1 -4.15344
PCCB propionyl CoA carboxylase, beta polypeptide -4.02173
CD58 CD58 molecule -3.64787
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.61467
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.37311
GNAS GNAS complex locus -3.34201
GET1 guided entry of tail-anchored proteins factor 1 -3.02723
PECR peroxisomal trans-2-enoyl-CoA reductase -3.02628
HEATR1 HEAT repeat containing 1 -3.02536
ACAA1 acetyl-CoA acyltransferase 1 -2.89629
YME1L1 YME1-like 1 ATPase -2.86032
ZNF586 zinc finger protein 586 -2.78619
STXBP2 syntaxin binding protein 2 -2.75773
TRIB3 tribbles pseudokinase 3 -2.69229
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.68081
TRAP1 TNF receptor-associated protein 1 -2.59838
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.55131
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.54468
GLOD4 glyoxalase domain containing 4 -2.49127
MAPK13 mitogen-activated protein kinase 13 -2.48657
BLCAP bladder cancer associated protein -2.48601
CCNB1 cyclin B1 -2.47282
ARID5B AT rich interactive domain 5B (MRF1-like) -2.41068
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.37265
WASHC4 WASH complex subunit 4 -2.27225
GRWD1 glutamate-rich WD repeat containing 1 -2.19876
MECR mitochondrial trans-2-enoyl-CoA reductase -2.1701
TCERG1 transcription elongation regulator 1 -2.16422
PGM1 phosphoglucomutase 1 -2.15745
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.13218
PYGL phosphorylase, glycogen, liver -2.11247
CDC25B cell division cycle 25B -2.07233
NCK2 NCK adaptor protein 2 -2.03059
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.00491