CRCGN014_HEPG2_3H:B13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-anisidine.hcl 39.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN014_HEPG2_3H:B13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 6.96255
CCDC92 coiled-coil domain containing 92 5.85636
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.16947
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 5.14109
MSRA methionine sulfoxide reductase A 4.97592
UBQLN2 ubiquilin 2 4.91929
CIAO3 cytosolic iron-sulfur assembly component 3 4.91668
GPER1 G protein-coupled estrogen receptor 1 4.67798
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.63865
EAPP E2F-associated phosphoprotein 4.59162
ATP11B ATPase, class VI, type 11B 4.26235
CYCS cytochrome c, somatic 3.50604
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.40857
NOSIP nitric oxide synthase interacting protein 3.01477
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.982
EVL Enah/Vasp-like 2.95463
VAV3 vav 3 guanine nucleotide exchange factor 2.79739
CCNH cyclin H 2.7859
KIF5C kinesin family member 5C 2.60379
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.58429
RPP38 ribonuclease P/MRP 38kDa subunit 2.51962
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.51622
IDE insulin-degrading enzyme 2.46016
IQGAP1 IQ motif containing GTPase activating protein 1 2.39188
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.3883
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.30262
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.22141
LAP3 leucine aminopeptidase 3 2.21812
ZNF589 zinc finger protein 589 2.20273
RBKS ribokinase 2.20089
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 2.17716
TNIP1 TNFAIP3 interacting protein 1 2.13089
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.11892
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.05906
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.03961
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.03209
CIDEB cell death-inducing DFFA-like effector b 2.00798
SREBF1 sterol regulatory element binding transcription factor 1 2.00086

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.53016
MRPS2 mitochondrial ribosomal protein S2 -5.2727
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.23961
PLK1 polo-like kinase 1 -5.18186
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.09382
CDC20 cell division cycle 20 -5.0518
PCNA proliferating cell nuclear antigen -4.95395
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.84113
PCCB propionyl CoA carboxylase, beta polypeptide -4.77732
ADI1 acireductone dioxygenase 1 -4.77485
COG2 component of oligomeric golgi complex 2 -4.53957
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.51787
CCNB2 cyclin B2 -4.51718
LDHD lactate dehydrogenase D -4.49285
FGFR4 fibroblast growth factor receptor 4 -4.05232
TLR4 toll-like receptor 4 -4.03285
TM9SF3 transmembrane 9 superfamily member 3 -3.84135
CSK c-src tyrosine kinase -3.4306
PYCR1 pyrroline-5-carboxylate reductase 1 -3.02225
OXA1L oxidase (cytochrome c) assembly 1-like -2.93106
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.88538
TBX4 T-box 4 -2.83519
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.69618
ZBP1 Z-DNA binding protein 1 -2.58044
ZNF134 zinc finger protein 134 -2.57523
TCF15 transcription factor 15 (basic helix-loop-helix) -2.56124
CD226 CD226 molecule -2.54566
MYOG myogenin (myogenic factor 4) -2.53233
CENPO centromere protein O -2.51105
STAMBP STAM binding protein -2.50349
ZNF324B zinc finger protein 324B -2.49898
FBXO22 F-box protein 22 -2.43709
UBE2S ubiquitin-conjugating enzyme E2S -2.41641
ZNF646 zinc finger protein 646 -2.41099
URM1 ubiquitin related modifier 1 -2.39259
SPINT4 serine peptidase inhibitor, Kunitz type 4 -2.36131
ROM1 retinal outer segment membrane protein 1 -2.32235
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.31556
RPAIN RPA interacting protein -2.29385
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.29114
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.28354
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.22667
GAS2 growth arrest-specific 2 -2.22404
PIWIL1 piwi-like RNA-mediated gene silencing 1 -2.22239
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 -2.19739
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.17838
ZNF304 zinc finger protein 304 -2.16724
EGF epidermal growth factor -2.16286
DAPK1 death-associated protein kinase 1 -2.15751
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.12863
ZNF551 zinc finger protein 551 -2.1187
ZNF234 zinc finger protein 234 -2.11602
PROS1 protein S (alpha) -2.10218
CASS4 Cas scaffolding protein family member 4 -2.10042
PTGFR prostaglandin F receptor (FP) -2.09541
VEGFC vascular endothelial growth factor C -2.08906
ATF7 activating transcription factor 7 -2.08166
ZNF329 zinc finger protein 329 -2.05771
PRDM8 PR domain containing 8 -2.05291
ZNF574 zinc finger protein 574 -2.04408
RIN1 Ras and Rab interactor 1 -2.04383
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.02569
WNT5B wingless-type MMTV integration site family, member 5B -2.01969
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.015
PCDHB1 protocadherin beta 1 -2.01334
ASIC1 acid sensing (proton gated) ion channel 1 -2.01039
VGLL3 vestigial-like family member 3 -2.01005