CRCGN014_HEPG2_3H:B17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c yellow no. 6 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN014_HEPG2_3H:B17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 6.1417
MAP7 microtubule-associated protein 7 5.22178
UBQLN2 ubiquilin 2 4.04138
RPP38 ribonuclease P/MRP 38kDa subunit 3.86433
MAMLD1 mastermind-like domain containing 1 3.63608
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.49336
PRKCH protein kinase C, eta 3.08018
STK10 serine/threonine kinase 10 2.96806
PRR15L proline rich 15-like 2.92097
SCYL3 SCY1-like 3 (S. cerevisiae) 2.59927
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.46638
SORBS3 sorbin and SH3 domain containing 3 2.43989
GPER1 G protein-coupled estrogen receptor 1 2.16479
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.14408
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.12906
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.12397

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
GNAS GNAS complex locus -7.79771
PLK1 polo-like kinase 1 -4.17104
PUF60 poly-U binding splicing factor 60KDa -3.96804
OXA1L oxidase (cytochrome c) assembly 1-like -3.41094
ZMIZ1 zinc finger, MIZ-type containing 1 -3.13405
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.01063
SLC35F2 solute carrier family 35, member F2 -3.00372
GDF15 growth differentiation factor 15 -2.91754
MAPK13 mitogen-activated protein kinase 13 -2.81154
ITGB1BP1 integrin beta 1 binding protein 1 -2.72667
CCNB2 cyclin B2 -2.69175
RXRG retinoid X receptor, gamma -2.67192
TLCD3A TLC domain containing 3A -2.61429
IGSF1 immunoglobulin superfamily, member 1 -2.43561
THEM6 thioesterase superfamily member 6 -2.43097
PYCR3 pyrroline-5-carboxylate reductase 3 -2.36338
TRPV5 transient receptor potential cation channel, subfamily V, member 5 -2.17432
ARID5B AT rich interactive domain 5B (MRF1-like) -2.10613
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.09099
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.05241
MRPS33 mitochondrial ribosomal protein S33 -2.03611
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.03393
RCVRN recoverin -2.02566