CRCGN014_HEPG2_3H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description choline chloride 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN014_HEPG2_3H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.2044
CYCS cytochrome c, somatic 4.77787
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.34345
UBQLN2 ubiquilin 2 4.2407
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.98714
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.47975
CXCL2 chemokine (C-X-C motif) ligand 2 3.38889
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.161
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.12684
HYOU1 hypoxia up-regulated 1 2.97726
MAP7 microtubule-associated protein 7 2.93307
CSK c-src tyrosine kinase 2.70316
SYNGAP1 synaptic Ras GTPase activating protein 1 2.62662
ABHD6 abhydrolase domain containing 6 2.59278
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.16452
MMP2 matrix metallopeptidase 2 2.11382

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.40203
ZNF586 zinc finger protein 586 -4.56345
PRPF4 pre-mRNA processing factor 4 -4.47598
CD320 CD320 molecule -4.20108
CCDC86 coiled-coil domain containing 86 -4.05524
MRPS2 mitochondrial ribosomal protein S2 -3.90899
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.6553
VAT1 vesicle amine transport 1 -2.89552
MTA1 metastasis associated 1 -2.46628
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.44669
BPHL biphenyl hydrolase-like (serine hydrolase) -2.22812
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.17064
PCNA proliferating cell nuclear antigen -2.07437
OXA1L oxidase (cytochrome c) assembly 1-like -2.04834