CRCGN014_HEPG2_3H:B22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN014_HEPG2_3H:B22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 9.94359
KIFBP kinesin family binding protein 4.82805
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.39329
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.20342
SFTPB surfactant protein B 4.13624
UBQLN2 ubiquilin 2 3.7491
TRIB3 tribbles pseudokinase 3 3.34452
EVL Enah/Vasp-like 3.34361
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.31781
TIAM1 T-cell lymphoma invasion and metastasis 1 3.20304
ADGRE5 adhesion G protein-coupled receptor E5 3.16278
RPP38 ribonuclease P/MRP 38kDa subunit 2.98769
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.82265
AARS1 alanyl-tRNA synthetase 1 2.7809
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.75255
MELK maternal embryonic leucine zipper kinase 2.69453
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.62018
CYCS cytochrome c, somatic 2.58188
C5 complement component 5 2.49892
SNX7 sorting nexin 7 2.47939
GOLT1B golgi transport 1B 2.45684
GADD45A growth arrest and DNA-damage-inducible, alpha 2.41781
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.4073
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.38948
CSK c-src tyrosine kinase 2.33447
FNTA farnesyltransferase, CAAX box, alpha 2.33244
ZNF589 zinc finger protein 589 2.31672
PTK2 protein tyrosine kinase 2 2.3149
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.24051
MAST2 microtubule associated serine/threonine kinase 2 2.23334
GSTZ1 glutathione S-transferase zeta 1 2.19239
TLK2 tousled-like kinase 2 2.15759
CARS1 cysteinyl-tRNA synthetase 1 2.14917
STIMATE STIM activating enhancer 2.14101
LOC128125814 uncharacterized LOC128125814 2.10992
DIPK1A divergent protein kinase domain 1A 2.09896
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.07053
KDM3A lysine (K)-specific demethylase 3A 2.01878
CGRRF1 cell growth regulator with ring finger domain 1 2.01536
ZBTB35 zinc finger and BTB domain containing 35 2.00173

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.9644
ZNF586 zinc finger protein 586 -6.00823
FASTKD5 FAST kinase domains 5 -5.39226
CD320 CD320 molecule -4.30904
LOC124907782 dual specificity protein phosphatase 22 -4.26165
GRWD1 glutamate-rich WD repeat containing 1 -4.12579
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.07142
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.62267
MRPS2 mitochondrial ribosomal protein S2 -3.50661
PRPF4 pre-mRNA processing factor 4 -3.30571
PSRC1 proline/serine-rich coiled-coil 1 -3.29964
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.10958
PARP2 poly (ADP-ribose) polymerase 2 -3.00389
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.70632
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.61563
TUBB6 tubulin, beta 6 class V -2.52942
CDK1 cyclin-dependent kinase 1 -2.46752
UBE2C ubiquitin-conjugating enzyme E2C -2.41038
WASHC4 WASH complex subunit 4 -2.36573
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.31158
ALDOC aldolase C, fructose-bisphosphate -2.24562
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.2071
KPTN kaptin (actin binding protein) -2.18874
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.16132
GTPBP8 GTP-binding protein 8 (putative) -2.12721
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.07866
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.02704
FMNL3 formin-like 3 -2.02056
PRKCD protein kinase C, delta -2.0005