CRCGN014_HEPG2_3H:B24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isopropanol 42.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN014_HEPG2_3H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.7019
MAP7 microtubule-associated protein 7 5.07353
PEX11A peroxisomal biogenesis factor 11 alpha 5.06777
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.99471
CHMP6 charged multivesicular body protein 6 3.61486
ADGRE5 adhesion G protein-coupled receptor E5 3.56685
ADRB2 adrenoceptor beta 2, surface 3.37582
CARMIL1 capping protein regulator and myosin 1 linker 1 3.33992
E2F2 E2F transcription factor 2 3.23816
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.18262
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.11617
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.00422
DIPK1A divergent protein kinase domain 1A 2.94285
FCHO1 FCH domain only 1 2.73972
MEST mesoderm specific transcript 2.73922
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.56756
VGLL4 vestigial-like family member 4 2.46762
CSK c-src tyrosine kinase 2.36113
PIH1D1 PIH1 domain containing 1 2.18286
USP6NL USP6 N-terminal like 2.08997
EXOSC4 exosome component 4 2.00342

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -5.70272
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.54946
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.34604
PRPF4 pre-mRNA processing factor 4 -3.33648
RFC2 replication factor C (activator 1) 2, 40kDa -3.05354
ZNF586 zinc finger protein 586 -3.04393
ZDHHC6 zinc finger, DHHC-type containing 6 -2.77505
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.60683
C2CD5 C2 calcium-dependent domain containing 5 -2.58652
GNAS GNAS complex locus -2.44825
NVL nuclear VCP-like -2.44371
EIF5 eukaryotic translation initiation factor 5 -2.27943
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.22524
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.21469
WASHC4 WASH complex subunit 4 -2.1789
RAI14 retinoic acid induced 14 -2.12093
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.06514