CRCGN014_HEPG2_3H:C02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethoxane 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

168 genes differentially expressed following the CRCGN014_HEPG2_3H:C02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO1 anoctamin 1, calcium activated chloride channel 8.36222
PMM2 phosphomannomutase 2 5.66257
CIAO3 cytosolic iron-sulfur assembly component 3 5.6291
CHMP6 charged multivesicular body protein 6 5.45443
MKNK1 MAP kinase interacting serine/threonine kinase 1 5.08538
CSK c-src tyrosine kinase 5.04009
PNKP polynucleotide kinase 3'-phosphatase 4.87902
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.73613
C2CD2 C2 calcium-dependent domain containing 2 4.53899
STK10 serine/threonine kinase 10 4.08536
LPAR2 lysophosphatidic acid receptor 2 3.81947
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.64642
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.63066
WDHD1 WD repeat and HMG-box DNA binding protein 1 3.39391
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.33046
SHB Src homology 2 domain containing adaptor protein B 3.22375
PFKL phosphofructokinase, liver 3.14024
SSBP2 single-stranded DNA binding protein 2 3.13424
HLA-DRA major histocompatibility complex, class II, DR alpha 3.126
LCN2 lipocalin 2 3.07541
RAB21 RAB21, member RAS oncogene family 3.02229
RPAP2 RNA polymerase II associated protein 2 2.96606
CCP110 centriolar coiled coil protein 110kDa 2.90306
EGF epidermal growth factor 2.8809
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.87564
HAT1 histone acetyltransferase 1 2.85138
TRAPPC10 trafficking protein particle complex 10 2.82571
SMIM40 small integral membrane protein 40 2.78043
BBS7 Bardet-Biedl syndrome 7 2.7725
TENT4A terminal nucleotidyltransferase 4A 2.7006
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.66236
FANCG Fanconi anemia, complementation group G 2.64504
DIPK1A divergent protein kinase domain 1A 2.61774
ANKEF1 ankyrin repeat and EF-hand domain containing 1 2.60128
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.59504
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.55348
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.54521
LOC122526780 uncharacterized LOC122526780 2.53053
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.49504
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.49208
MIMS2 mitochondrial inner membrane scaffold 2 2.48707
EFNA4 ephrin-A4 2.46985
NUP153 nucleoporin 153kDa 2.45198
ARHGAP11A Rho GTPase activating protein 11A 2.44667
MCPH1 microcephalin 1 2.44385
GPALPP1 GPALPP motifs containing 1 2.43672
RAG2 recombination activating gene 2 2.42468
GDAP2 ganglioside induced differentiation associated protein 2 2.41434
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.40482
WRN Werner syndrome, RecQ helicase-like 2.36752
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.36436
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.34568
GPR63 G protein-coupled receptor 63 2.34095
NABP1 nucleic acid binding protein 1 2.32138
NHLRC2 NHL repeat containing 2 2.31191
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.29208
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.29089
DENND4A DENN/MADD domain containing 4A 2.28531
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.27082
TDRD12 tudor domain containing 12 2.25517
LIN9 lin-9 DREAM MuvB core complex component 2.23522
ATAD2B ATPase family, AAA domain containing 2B 2.22856
ALMS1 Alstrom syndrome protein 1 2.2279
MAGOHB mago-nashi homolog B (Drosophila) 2.22458
RAG1 recombination activating gene 1 2.22079
MMP2 matrix metallopeptidase 2 2.21164
PRCC papillary renal cell carcinoma (translocation-associated) 2.19806
TBP TATA box binding protein 2.18282
WDR3 WD repeat domain 3 2.17229
OBI1 ORC ubiquitin ligase 1 2.17089
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.16757
STXBP2 syntaxin binding protein 2 2.15301
EBI3 Epstein-Barr virus induced 3 2.1403
ANXA9 annexin A9 2.13194
NIT1 nitrilase 1 2.11755
GC group-specific component (vitamin D binding protein) 2.1168
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.11608
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.11336
ZC3H7A zinc finger CCCH-type containing 7A 2.10907
VTN vitronectin 2.09141
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.09089
PRH1 proline-rich protein HaeIII subfamily 1 2.08199
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.07947
HELLS helicase, lymphoid-specific 2.07809
ETAA1 Ewing tumor-associated antigen 1 2.07528
VPS26C VPS26 endosomal protein sorting factor C 2.06751
NUP62CL nucleoporin 62kDa C-terminal like 2.05265
SAA2 serum amyloid A2 2.05058
N4BP3 NEDD4 binding protein 3 2.05051
BRWD1 bromodomain and WD repeat domain containing 1 2.04483
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.043
DCTN3 dynactin 3 (p22) 2.03327
IQCB1 IQ motif containing B1 2.03272
TMPRSS3 transmembrane protease, serine 3 2.03161
PLAA phospholipase A2-activating protein 2.02978
KIF11 kinesin family member 11 2.02522
CLEC2D C-type lectin domain family 2, member D 2.01526
PLXNB2 plexin B2 2.01394
JMJD7 jumonji domain containing 7 2.0136
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.01032
FMNL3 formin-like 3 2.00242
QSER1 glutamine and serine rich 1 2.00072

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.42439
GNAS GNAS complex locus -7.1999
SLC35F2 solute carrier family 35, member F2 -5.89066
VAT1 vesicle amine transport 1 -5.82811
OXA1L oxidase (cytochrome c) assembly 1-like -5.25426
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.14691
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.74122
DNM1L dynamin 1-like -4.4869
UBE3C ubiquitin protein ligase E3C -4.20171
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.19267
HMG20B high mobility group 20B -3.88692
DERA deoxyribose-phosphate aldolase (putative) -3.79379
CCNB2 cyclin B2 -3.60021
TXNDC9 thioredoxin domain containing 9 -3.5904
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.40318
TLCD3A TLC domain containing 3A -3.31117
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.3004
TLR4 toll-like receptor 4 -3.14311
HSPB1 heat shock 27kDa protein 1 -3.05315
CATSPERZ catsper channel auxiliary subunit zeta -2.98101
CCNB1 cyclin B1 -2.64657
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.63791
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.6295
MTERF3 mitochondrial transcription termination factor 3 -2.58849
CNTNAP1 contactin associated protein 1 -2.56893
TBX2 T-box 2 -2.49824
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.41318
WASHC4 WASH complex subunit 4 -2.40784
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.38377
MAP2K2 mitogen-activated protein kinase kinase 2 -2.358
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.34149
ACTMAP actin maturation protease -2.32634
GOLGA8N golgin A8 family, member N -2.32561
RPL36AL ribosomal protein L36a-like -2.29663
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.28689
RLIM ring finger protein, LIM domain interacting -2.27574
COX6C cytochrome c oxidase subunit VIc -2.27116
SNX6 sorting nexin 6 -2.23058
COCH cochlin -2.20787
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.20058
FKBP3 FK506 binding protein 3, 25kDa -2.18811
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -2.16167
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -2.16039
MTARC1 mitochondrial amidoxime reducing component 1 -2.14915
EIF3E eukaryotic translation initiation factor 3, subunit E -2.1471
MRPL33 mitochondrial ribosomal protein L33 -2.1299
RSRC2 arginine/serine-rich coiled-coil 2 -2.12819
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.12455
ATG9A autophagy related 9A -2.12118
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -2.11056
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.10777
NPY neuropeptide Y -2.10417
RAB32 RAB32, member RAS oncogene family -2.10129
PTPRD protein tyrosine phosphatase, receptor type, D -2.09423
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.0924
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.0913
LRP10 low density lipoprotein receptor-related protein 10 -2.09044
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -2.07446
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.05536
TOMM70 translocase of outer mitochondrial membrane 70 -2.04988
RNF139 ring finger protein 139 -2.03475
ETFB electron-transfer-flavoprotein, beta polypeptide -2.03339
NBPF3 neuroblastoma breakpoint family, member 3 -2.03178
USF2 upstream transcription factor 2, c-fos interacting -2.01168
STIM1 stromal interaction molecule 1 -2.01005
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.00942