CRCGN014_HEPG2_3H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN014_HEPG2_3H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 9.68347
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.47157
HYOU1 hypoxia up-regulated 1 5.11138
LCN2 lipocalin 2 5.05995
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.70235
ADRB2 adrenoceptor beta 2, surface 3.66886
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.64294
MSRA methionine sulfoxide reductase A 3.54684
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.49854
LYN LYN proto-oncogene, Src family tyrosine kinase 3.47707
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.42201
USP6NL USP6 N-terminal like 3.39106
SLC35B1 solute carrier family 35, member B1 3.36179
FZD1 frizzled class receptor 1 3.10095
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.92173
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.90219
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.81948
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.7449
ANO1 anoctamin 1, calcium activated chloride channel 2.70867
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.60584
AXIN1 axin 1 2.52164
SAA2 serum amyloid A2 2.41706
CYCS cytochrome c, somatic 2.39173
SHB Src homology 2 domain containing adaptor protein B 2.38276
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.37573
E2F2 E2F transcription factor 2 2.33811
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.27232
RFPL3 ret finger protein-like 3 2.25703
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.22435
TP53 tumor protein p53 2.22015
GOLT1B golgi transport 1B 2.21991
TBC1D10C TBC1 domain family, member 10C 2.20282
ARMCX1 armadillo repeat containing, X-linked 1 2.15252
NUCB2 nucleobindin 2 2.14853
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.13184
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.1206
ZBTB18 zinc finger and BTB domain containing 18 2.11029
LPAR2 lysophosphatidic acid receptor 2 2.06349
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.05185
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.01694
CBR3 carbonyl reductase 3 2.00751
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.0054

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.22642
ZNF586 zinc finger protein 586 -5.51244
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.59773
VAT1 vesicle amine transport 1 -4.19047
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.16218
CDC20 cell division cycle 20 -4.1129
SLC35F2 solute carrier family 35, member F2 -4.07865
OXA1L oxidase (cytochrome c) assembly 1-like -4.06618
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.57714
LDHD lactate dehydrogenase D -3.37234
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.21036
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.16597
GNAS GNAS complex locus -3.04913
PRPF4 pre-mRNA processing factor 4 -2.97833
CSK c-src tyrosine kinase -2.90761
DNM1L dynamin 1-like -2.56648
LOC124907782 dual specificity protein phosphatase 22 -2.50266
ANKRD10 ankyrin repeat domain 10 -2.4145
TLCD3A TLC domain containing 3A -2.39921
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.35217
HMOX1 heme oxygenase 1 -2.34111
REEP5 receptor accessory protein 5 -2.33885
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.24159
GIPC1 GIPC PDZ domain containing family, member 1 -2.19012
TACC3 transforming, acidic coiled-coil containing protein 3 -2.12141
NRIP1 nuclear receptor interacting protein 1 -2.06308
ADAR adenosine deaminase, RNA-specific -2.05902
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.02658
GSTK1 glutathione S-transferase kappa 1 -2.00693
MACF1 microtubule-actin crosslinking factor 1 -2.00526