CRCGN014_HEPG2_3H:C04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-phenyl-p-phenylenediamine.hcl 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

61 genes differentially expressed following the CRCGN014_HEPG2_3H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.57746
MAP7 microtubule-associated protein 7 4.85777
CARMIL1 capping protein regulator and myosin 1 linker 1 4.37188
HOXA5 homeobox A5 4.24344
KLHL21 kelch-like family member 21 4.23106
GSTZ1 glutathione S-transferase zeta 1 3.83164
PPIC peptidylprolyl isomerase C (cyclophilin C) 3.46563
NOTCH1 notch 1 3.45897
STIMATE STIM activating enhancer 3.4549
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.2925
BACE2 beta-site APP-cleaving enzyme 2 3.20128
CHN1 chimerin 1 3.17688
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.12829
SFTPB surfactant protein B 3.03676
HSPA1A heat shock 70kDa protein 1A 3.02742
SQSTM1 sequestosome 1 2.8519
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.76369
MCOLN1 mucolipin 1 2.67658
MYLK myosin light chain kinase 2.60769
ILK integrin-linked kinase 2.58616
CYCS cytochrome c, somatic 2.58135
IER3 immediate early response 3 2.56511
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.48728
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.41704
GPER1 G protein-coupled estrogen receptor 1 2.40808
TXNRD1 thioredoxin reductase 1 2.37225
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.33049
SLC75A1 solute carrier family 75 member 1 2.30136
STX1A syntaxin 1A (brain) 2.29957
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.29438
FOSL1 FOS-like antigen 1 2.2897
LRRC36 leucine rich repeat containing 36 2.28247
LAGE3 L antigen family, member 3 2.27143
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.26121
ICAM1 intercellular adhesion molecule 1 2.18367
ZW10 zw10 kinetochore protein 2.16634
ABHD4 abhydrolase domain containing 4 2.10702
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.06279
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.06028

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.56814
CDC25B cell division cycle 25B -5.75219
LDHD lactate dehydrogenase D -4.0235
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.02239
TBC1D31 TBC1 domain family, member 31 -3.88865
PSRC1 proline/serine-rich coiled-coil 1 -3.80556
CCNB1 cyclin B1 -3.76977
TLR4 toll-like receptor 4 -3.49352
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.86345
MAPK13 mitogen-activated protein kinase 13 -2.66922
GNAS GNAS complex locus -2.58077
EIF5 eukaryotic translation initiation factor 5 -2.45821
UBE2C ubiquitin-conjugating enzyme E2C -2.43908
MTA1 metastasis associated 1 -2.38167
TRIB3 tribbles pseudokinase 3 -2.36553
TLCD3A TLC domain containing 3A -2.35874
HMG20B high mobility group 20B -2.26817
PLK1 polo-like kinase 1 -2.22088
CDC20 cell division cycle 20 -2.20274
ADAR adenosine deaminase, RNA-specific -2.12269
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.06456
OXA1L oxidase (cytochrome c) assembly 1-like -2.06436