CRCGN014_HEPG2_3H:C07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-ethyl-2-hexenal 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN014_HEPG2_3H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.05126
STIMATE STIM activating enhancer 4.6721
CBR3 carbonyl reductase 3 4.48033
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.29794
ADRB2 adrenoceptor beta 2, surface 4.14175
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.06967
MELK maternal embryonic leucine zipper kinase 3.89471
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.74157
RPP38 ribonuclease P/MRP 38kDa subunit 3.65064
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.40258
CYCS cytochrome c, somatic 3.2708
GSTZ1 glutathione S-transferase zeta 1 3.06036
VAV3 vav 3 guanine nucleotide exchange factor 2.93754
LPAR2 lysophosphatidic acid receptor 2 2.76222
ZNF589 zinc finger protein 589 2.68267
HLA-DRA major histocompatibility complex, class II, DR alpha 2.46635
DIPK1A divergent protein kinase domain 1A 2.40423
MEST mesoderm specific transcript 2.38701
SELENBP1 selenium binding protein 1 2.33064
SFTPB surfactant protein B 2.24466
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.12631
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.04018
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.0368
LY96 lymphocyte antigen 96 2.01999
ILK integrin-linked kinase 2.00474

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.33297
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.58715
CCNB2 cyclin B2 -4.28868
GNAS GNAS complex locus -4.09083
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.6693
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.54921
TBC1D31 TBC1 domain family, member 31 -3.24181
TLCD3A TLC domain containing 3A -3.04453
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.48903
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.48564
NUSAP1 nucleolar and spindle associated protein 1 -2.19265
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.16183
RGS2 regulator of G-protein signaling 2 -2.14989
SNX11 sorting nexin 11 -2.1319
FIP1L1 factor interacting with PAPOLA and CPSF1 -2.07893
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.06142
SKIC3 SKI3 subunit of superkiller complex -2.05142