CRCGN014_HEPG2_3H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-vinylpyrrolidone-2 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

141 genes differentially expressed following the CRCGN014_HEPG2_3H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.59074
CHMP6 charged multivesicular body protein 6 5.76734
MAP7 microtubule-associated protein 7 5.13985
CCL2 chemokine (C-C motif) ligand 2 4.68279
RPP38 ribonuclease P/MRP 38kDa subunit 4.50217
CXCL2 chemokine (C-X-C motif) ligand 2 4.16358
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.87431
VGLL4 vestigial-like family member 4 3.7688
BMP4 bone morphogenetic protein 4 3.76775
SYNGAP1 synaptic Ras GTPase activating protein 1 3.63946
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.51259
E2F2 E2F transcription factor 2 3.41214
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.25112
CTSL cathepsin L 3.23064
ADGRE5 adhesion G protein-coupled receptor E5 3.22411
CYCS cytochrome c, somatic 3.22364
ANO1 anoctamin 1, calcium activated chloride channel 3.19471
TNIP1 TNFAIP3 interacting protein 1 3.14652
FCHO1 FCH domain only 1 3.11721
MCOLN1 mucolipin 1 3.11348
ALDOC aldolase C, fructose-bisphosphate 3.06033
JADE2 jade family PHD finger 2 3.05416
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 3.04884
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 3.02907
PRAF2 PRA1 domain family, member 2 2.98966
DUSP4 dual specificity phosphatase 4 2.91414
TICAM1 toll-like receptor adaptor molecule 1 2.84266
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.78006
C2CD2 C2 calcium-dependent domain containing 2 2.75951
AMDHD2 amidohydrolase domain containing 2 2.71684
GPER1 G protein-coupled estrogen receptor 1 2.6974
STK10 serine/threonine kinase 10 2.6288
MAD2L1BP MAD2L1 binding protein 2.59237
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.5693
MPC2 mitochondrial pyruvate carrier 2 2.51879
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.51325
TAC4 tachykinin 4 (hemokinin) 2.49244
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.49065
ABHD6 abhydrolase domain containing 6 2.45247
TIAM1 T-cell lymphoma invasion and metastasis 1 2.43481
MRPL17 mitochondrial ribosomal protein L17 2.43429
HEBP1 heme binding protein 1 2.41317
PPARG peroxisome proliferator-activated receptor gamma 2.40621
SNAP25 synaptosomal-associated protein, 25kDa 2.39852
RRAGA Ras-related GTP binding A 2.39405
PRKCD protein kinase C, delta 2.39338
IDE insulin-degrading enzyme 2.37183
OXCT1 3-oxoacid CoA transferase 1 2.36314
IFI35 interferon-induced protein 35 2.35155
EPN2 epsin 2 2.34014
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.32617
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.31647
CD177 CD177 molecule 2.31316
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.30248
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 2.27999
LHFPL2 lipoma HMGIC fusion partner-like 2 2.23961
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.21198
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.20596
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.19649
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.19281
GBA1 glucosylceramidase beta 1 2.17429
PNKP polynucleotide kinase 3'-phosphatase 2.14661
SYNPO synaptopodin 2.13617
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.12369
PFKP phosphofructokinase, platelet 2.11312
TRAK2 trafficking protein, kinesin binding 2 2.10738
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.08954
IGFBP3 insulin-like growth factor binding protein 3 2.08059
TBC1D10C TBC1 domain family, member 10C 2.07151
PTK2 protein tyrosine kinase 2 2.06953
IFI44L interferon-induced protein 44-like 2.06922
ENOSF1 enolase superfamily member 1 2.06531
TREM1 triggering receptor expressed on myeloid cells 1 2.0589
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.05856
CDK18 cyclin-dependent kinase 18 2.04807
IRF7 interferon regulatory factor 7 2.04794
MEST mesoderm specific transcript 2.0212
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.01933
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.01577

decreased expression

Symbol Name Standardized Value
ARID5B AT rich interactive domain 5B (MRF1-like) -7.31779
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.1332
LDHD lactate dehydrogenase D -6.79692
BPHL biphenyl hydrolase-like (serine hydrolase) -5.97558
GNAS GNAS complex locus -5.78047
OXA1L oxidase (cytochrome c) assembly 1-like -5.50579
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.08772
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.96929
NT5DC2 5'-nucleotidase domain containing 2 -3.94811
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.93747
CBR1 carbonyl reductase 1 -3.57233
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.38494
COG2 component of oligomeric golgi complex 2 -3.15456
CCNB1 cyclin B1 -3.14599
AKAP8 A kinase (PRKA) anchor protein 8 -3.01003
TRIB3 tribbles pseudokinase 3 -2.95279
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -2.82976
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.79613
TLCD3A TLC domain containing 3A -2.73924
WDR7 WD repeat domain 7 -2.71498
MRPS2 mitochondrial ribosomal protein S2 -2.59828
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -2.59824
FOSL1 FOS-like antigen 1 -2.54761
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.5201
NENF neudesin neurotrophic factor -2.49479
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.47062
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.44907
DERA deoxyribose-phosphate aldolase (putative) -2.41423
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.40188
KCMF1 potassium channel modulatory factor 1 -2.32935
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -2.31082
FAT1 FAT atypical cadherin 1 -2.30047
CKAP4 cytoskeleton-associated protein 4 -2.28579
TBPL1 TBP-like 1 -2.27494
PGM1 phosphoglucomutase 1 -2.27058
LOC124907782 dual specificity protein phosphatase 22 -2.24475
ZFYVE9 zinc finger, FYVE domain containing 9 -2.23782
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.23099
NCK2 NCK adaptor protein 2 -2.2176
RTL8C retrotransposon Gag like 8C -2.1993
BECN1 beclin 1, autophagy related -2.18265
RPL38 ribosomal protein L38 -2.17777
MXD3 MAX dimerization protein 3 -2.14416
RNF167 ring finger protein 167 -2.13627
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.13407
LGMN legumain -2.12228
CZIB CXXC motif containing zinc binding protein -2.11158
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -2.10807
CLTB clathrin, light chain B -2.10494
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.08638
PVRIG poliovirus receptor related immunoglobulin domain containing -2.07621
MAP2K1 mitogen-activated protein kinase kinase 1 -2.07197
ZNF32 zinc finger protein 32 -2.07195
TMEM123 transmembrane protein 123 -2.06407
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.06075
LOC102723713 TP53-target gene 3 protein -2.04883
CCDC181 coiled-coil domain containing 181 -2.04271
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.02757
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.02736
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.02022
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.00396
MZT2B mitotic spindle organizing protein 2B -2.00338