CRCGN014_HEPG2_3H:C10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description maleic hydrazide 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN014_HEPG2_3H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.65244
CIAO3 cytosolic iron-sulfur assembly component 3 8.643
ZNF589 zinc finger protein 589 4.9633
DYNLT3 dynein, light chain, Tctex-type 3 4.92198
MYLK myosin light chain kinase 4.34898
CYCS cytochrome c, somatic 4.03275
CXCL2 chemokine (C-X-C motif) ligand 2 3.87094
C2CD2 C2 calcium-dependent domain containing 2 3.77892
GSTZ1 glutathione S-transferase zeta 1 3.69724
FCHO1 FCH domain only 1 3.49245
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.15751
AQP7 aquaporin 7 3.09618
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.08704
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.05429
GPATCH8 G patch domain containing 8 2.93619
SAA2 serum amyloid A2 2.92567
SCRN1 secernin 1 2.89009
LEP leptin 2.76362
SFTPB surfactant protein B 2.73979
LHCGR luteinizing hormone/choriogonadotropin receptor 2.70523
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.67782
NSUN5 NOP2/Sun domain family, member 5 2.67195
CIDEC cell death-inducing DFFA-like effector c 2.66145
NALF2 NALCN channel auxiliary factor 2 2.63377
VGLL4 vestigial-like family member 4 2.5929
IL25 interleukin 25 2.58714
PVRIG poliovirus receptor related immunoglobulin domain containing 2.53305
PLIN1 perilipin 1 2.5079
ADIPOQ adiponectin, C1Q and collagen domain containing 2.45248
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.45078
DMTF1 cyclin D binding myb-like transcription factor 1 2.41274
GFRA4 GDNF family receptor alpha 4 2.41116
RAG1 recombination activating gene 1 2.40976
KYAT3 kynurenine aminotransferase 3 2.4083
OCM2 oncomodulin 2 2.40402
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.39625
AOC3 amine oxidase, copper containing 3 2.36254
TMEM19 transmembrane protein 19 2.35364
CIDEA cell death-inducing DFFA-like effector a 2.32791
FABP4 fatty acid binding protein 4, adipocyte 2.3209
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.30432
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.29894
SAMD14 sterile alpha motif domain containing 14 2.28673
LPAR2 lysophosphatidic acid receptor 2 2.27878
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.27743
PRDM14 PR domain containing 14 2.27621
RNLS renalase, FAD-dependent amine oxidase 2.27524
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.27376
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.26636
SCYL3 SCY1-like 3 (S. cerevisiae) 2.25882
EPHA3 EPH receptor A3 2.23669
OR1E1 olfactory receptor, family 1, subfamily E, member 1 2.22072
HOXA2 homeobox A2 2.17975
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.15906
RRH retinal pigment epithelium-derived rhodopsin homolog 2.15884
TPD52L2 tumor protein D52-like 2 2.15738
NOD1 nucleotide-binding oligomerization domain containing 1 2.15627
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.14747
VENTX VENT homeobox 2.14646
OR7A10 olfactory receptor, family 7, subfamily A, member 10 2.14599
JADE2 jade family PHD finger 2 2.14149
GJA9 gap junction protein, alpha 9, 59kDa 2.12989
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 2.12947
SPRED2 sprouty-related, EVH1 domain containing 2 2.12315
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.11621
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 2.11144
SRSF4 serine/arginine-rich splicing factor 4 2.11031
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.10787
CRMP1 collapsin response mediator protein 1 2.1056
NLGN4Y neuroligin 4, Y-linked 2.09962
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.09611
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.09279
GIMAP5 GTPase, IMAP family member 5 2.09042
TMPRSS5 transmembrane protease, serine 5 2.0828
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.07195
ZIC3 Zic family member 3 2.07178
MYBPC3 myosin binding protein C, cardiac 2.06778
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.06749
KRT32 keratin 32, type I 2.06689
PRKCE protein kinase C, epsilon 2.06662
DYNC2I1 dynein 2 intermediate chain 1 2.0523
DCAF13 DDB1 and CUL4 associated factor 13 2.05003
SMYD5 SMYD family member 5 2.04756
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.04733
ZNF507 zinc finger protein 507 2.04527
LGI2 leucine-rich repeat LGI family, member 2 2.0441
ACAD10 acyl-CoA dehydrogenase family, member 10 2.04063
IKZF2 IKAROS family zinc finger 2 (Helios) 2.03032
GPR45 G protein-coupled receptor 45 2.02745
UBASH3A ubiquitin associated and SH3 domain containing A 2.02406
ADAM21 ADAM metallopeptidase domain 21 2.01849
KRT83 keratin 83, type II 2.01344
TAAR2 trace amine associated receptor 2 2.01116
TNMD tenomodulin 2.01101
RPL3 ribosomal protein L3 2.0058
ZNF154 zinc finger protein 154 2.00452
NPY4R2 neuropeptide Y receptor Y4-2 2.00428

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -8.7363
SLC35F2 solute carrier family 35, member F2 -4.52873
ZNF586 zinc finger protein 586 -4.36
PRPF4 pre-mRNA processing factor 4 -4.32503
PLK1 polo-like kinase 1 -4.21035
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.19275
ECH1 enoyl CoA hydratase 1, peroxisomal -3.85346
FASTKD5 FAST kinase domains 5 -3.67756
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.67792
WASHC4 WASH complex subunit 4 -2.40867
MB myoglobin -2.30369
NGRN neugrin, neurite outgrowth associated -2.27058
ZFYVE16 zinc finger, FYVE domain containing 16 -2.23051
VAT1 vesicle amine transport 1 -2.17781
QPRT quinolinate phosphoribosyltransferase -2.16265
TTC38 tetratricopeptide repeat domain 38 -2.13364
SNX11 sorting nexin 11 -2.0855
ANXA7 annexin A7 -2.06311
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.05298
AGO2 argonaute RISC catalytic component 2 -2.04492
RNF139 ring finger protein 139 -2.02056
BAZ2B bromodomain adjacent to zinc finger domain, 2B -2.00515
TXNDC9 thioredoxin domain containing 9 -2.00218
NIP7 NIP7, nucleolar pre-rRNA processing protein -2.00029