CRCGN014_HEPG2_3H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrosotoluene 40.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN014_HEPG2_3H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.1448
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.11047
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.4004
HMOX1 heme oxygenase 1 5.27353
CBR3 carbonyl reductase 3 4.92367
CCL2 chemokine (C-C motif) ligand 2 4.62273
RPL39L ribosomal protein L39-like 4.5652
CHN1 chimerin 1 4.44971
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2477
SYNGAP1 synaptic Ras GTPase activating protein 1 4.22148
HSPA1A heat shock 70kDa protein 1A 4.19925
C2CD2 C2 calcium-dependent domain containing 2 4.12052
STIMATE STIM activating enhancer 4.09763
UBQLN2 ubiquilin 2 3.6237
IQGAP1 IQ motif containing GTPase activating protein 1 3.60771
PMM2 phosphomannomutase 2 3.5346
MYLK myosin light chain kinase 3.34557
TXNRD1 thioredoxin reductase 1 3.31055
GPER1 G protein-coupled estrogen receptor 1 3.23272
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.22887
STK10 serine/threonine kinase 10 3.14338
CIAO3 cytosolic iron-sulfur assembly component 3 3.113
CXCL2 chemokine (C-X-C motif) ligand 2 3.00097
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.987
CARMIL1 capping protein regulator and myosin 1 linker 1 2.87259
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.7716
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.57531
FOSL1 FOS-like antigen 1 2.48513
EPHB2 EPH receptor B2 2.4631
TERT telomerase reverse transcriptase 2.45822
CEP57 centrosomal protein 57kDa 2.43935
CYCS cytochrome c, somatic 2.40977
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.35639
IDE insulin-degrading enzyme 2.35293
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.33035
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.31579
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.30901
BAG3 BCL2-associated athanogene 3 2.2922
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.23277
ABHD4 abhydrolase domain containing 4 2.23007
MAP7 microtubule-associated protein 7 2.21797
STAP2 signal transducing adaptor family member 2 2.21567
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.21461
MAMLD1 mastermind-like domain containing 1 2.18294
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.11855
RGS20 regulator of G-protein signaling 20 2.01939

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.79839
CCNB2 cyclin B2 -5.3075
TLR4 toll-like receptor 4 -5.28035
GNAS GNAS complex locus -5.22132
ANKRD10 ankyrin repeat domain 10 -4.34896
CDC20 cell division cycle 20 -3.99515
BPHL biphenyl hydrolase-like (serine hydrolase) -3.88964
LDHD lactate dehydrogenase D -3.47515
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.2335
GOLT1B golgi transport 1B -3.15833
PRPF4 pre-mRNA processing factor 4 -2.9877
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.8133
KDM3A lysine (K)-specific demethylase 3A -2.77021
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.75761
WDR7 WD repeat domain 7 -2.58006
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.53075
CD320 CD320 molecule -2.5252
CDK6 cyclin-dependent kinase 6 -2.48988
FGFR4 fibroblast growth factor receptor 4 -2.48414
LOC124907782 dual specificity protein phosphatase 22 -2.44706
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.40907
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.3107
GCAT glycine C-acetyltransferase -2.2529
MTERF3 mitochondrial transcription termination factor 3 -2.23943
ZNF22 zinc finger protein 22 -2.22865
SCCPDH saccharopine dehydrogenase (putative) -2.22664
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.19671
HAT1 histone acetyltransferase 1 -2.15733
NECTIN2 nectin cell adhesion molecule 2 -2.15071
NT5DC2 5'-nucleotidase domain containing 2 -2.12174
PGM1 phosphoglucomutase 1 -2.11305
RNF167 ring finger protein 167 -2.07026
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.03424
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.02385