CRCGN014_HEPG2_3H:C14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN014_HEPG2_3H:C14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 5.71003
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.86782
E2F2 E2F transcription factor 2 4.60844
NOTCH1 notch 1 4.46436
CXCL2 chemokine (C-X-C motif) ligand 2 4.37116
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.24613
LCN2 lipocalin 2 4.18785
ABHD4 abhydrolase domain containing 4 4.16043
SATB1 SATB homeobox 1 3.83913
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.74113
MAP7 microtubule-associated protein 7 3.65705
SKIC8 SKI8 subunit of superkiller complex 3.50545
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.38761
CYCS cytochrome c, somatic 3.38258
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.10333
GATA2 GATA binding protein 2 2.83663
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.54072
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.34069
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.17474
CCNF cyclin F 2.16565
STIMATE STIM activating enhancer 2.0836
HIRIP3 HIRA interacting protein 3 2.06232
OSBP2 oxysterol binding protein 2 2.05319
ARMC1 armadillo repeat containing 1 2.02557
ZNF589 zinc finger protein 589 2.02045

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.13372
OXA1L oxidase (cytochrome c) assembly 1-like -6.3478
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.55887
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.84417
TXNRD1 thioredoxin reductase 1 -4.33167
LDHD lactate dehydrogenase D -4.25204
ADI1 acireductone dioxygenase 1 -4.01923
TLCD3A TLC domain containing 3A -3.41559
GNAS GNAS complex locus -3.38109
TLR4 toll-like receptor 4 -3.37095
SNX11 sorting nexin 11 -3.35246
RHEB Ras homolog enriched in brain -3.35101
ACLY ATP citrate lyase -3.25587
CDC25B cell division cycle 25B -3.07945
ACAA1 acetyl-CoA acyltransferase 1 -3.06184
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.78236
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.77687
TXNDC9 thioredoxin domain containing 9 -2.68872
CSK c-src tyrosine kinase -2.67655
ZNF586 zinc finger protein 586 -2.55016
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.41105
HLA-DMA major histocompatibility complex, class II, DM alpha -2.36968
GET1 guided entry of tail-anchored proteins factor 1 -2.307
TDRD1 tudor domain containing 1 -2.25676
OR1A1 olfactory receptor, family 1, subfamily A, member 1 -2.21214
TAS2R4 taste receptor, type 2, member 4 -2.12289
ACVR2A activin A receptor, type IIA -2.11697
OR5I1 olfactory receptor, family 5, subfamily I, member 1 -2.10968
CEP112 centrosomal protein 112kDa -2.09372
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.09071
FRAS1 Fraser extracellular matrix complex subunit 1 -2.08269
SLC35G2 solute carrier family 35, member G2 -2.08118
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -2.08105
TAAR2 trace amine associated receptor 2 -2.07434
CHPF2 chondroitin polymerizing factor 2 -2.05743
P3H1 prolyl 3-hydroxylase 1 -2.0574
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -2.04713
WASHC4 WASH complex subunit 4 -2.0278
FBXL2 F-box and leucine-rich repeat protein 2 -2.02078
PROS1 protein S (alpha) -2.01767
CPNE2 copine II -2.01594