CRCGN014_HEPG2_3H:C15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description citral 40.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN014_HEPG2_3H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.41814
KCNK1 potassium channel, two pore domain subfamily K, member 1 6.48244
HMOX1 heme oxygenase 1 4.98053
LCN2 lipocalin 2 4.58357
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.48238
EPHB2 EPH receptor B2 4.39166
E2F2 E2F transcription factor 2 4.18915
STK10 serine/threonine kinase 10 4.16191
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.91956
PEX11A peroxisomal biogenesis factor 11 alpha 3.6909
TERT telomerase reverse transcriptase 3.46699
TXNRD1 thioredoxin reductase 1 3.20161
ADGRE5 adhesion G protein-coupled receptor E5 3.1801
GSTZ1 glutathione S-transferase zeta 1 3.10383
CBR3 carbonyl reductase 3 2.99823
CHN1 chimerin 1 2.85134
LPAR2 lysophosphatidic acid receptor 2 2.80807
NOSIP nitric oxide synthase interacting protein 2.71248
ABHD4 abhydrolase domain containing 4 2.6978
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.63172
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.59654
CCL2 chemokine (C-C motif) ligand 2 2.5016
GPER1 G protein-coupled estrogen receptor 1 2.42388
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.42183
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.41504
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.4052
TBXA2R thromboxane A2 receptor 2.32998
CEP57 centrosomal protein 57kDa 2.29314
GCLM glutamate-cysteine ligase, modifier subunit 2.28009
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.27976
REG1B regenerating islet-derived 1 beta 2.23878
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.18125
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.17843
CEMIP2 cell migration inducing hyaluronidase 2 2.16025
TRIM15 tripartite motif containing 15 2.13505
MCUR1 mitochondrial calcium uniporter regulator 1 2.10408
CISD1 CDGSH iron sulfur domain 1 2.0923
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.08358
CHEK2 checkpoint kinase 2 2.06666
UGDH UDP-glucose 6-dehydrogenase 2.04895
ULBP2 UL16 binding protein 2 2.04623
RBKS ribokinase 2.03831
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.02156
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.00296

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.5603
GNAS GNAS complex locus -6.26923
PCNA proliferating cell nuclear antigen -5.77346
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.33228
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.02163
OXA1L oxidase (cytochrome c) assembly 1-like -3.62074
LDHD lactate dehydrogenase D -3.56189
PECR peroxisomal trans-2-enoyl-CoA reductase -3.56095
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.52237
CCNB2 cyclin B2 -3.40454
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.2317
HAT1 histone acetyltransferase 1 -3.012
SNX11 sorting nexin 11 -3.00697
NVL nuclear VCP-like -2.85829
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.4206
NRIP1 nuclear receptor interacting protein 1 -2.35017
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.33146
PMM2 phosphomannomutase 2 -2.15833
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.09066
PYGL phosphorylase, glycogen, liver -2.0306
ZNF134 zinc finger protein 134 -2.01414
SLC35F2 solute carrier family 35, member F2 -2.00915