CRCGN014_HEPG2_3H:C16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trans-cinnamaldehyde 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

91 genes differentially expressed following the CRCGN014_HEPG2_3H:C16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 9.82468
HMOX1 heme oxygenase 1 9.43501
ABHD4 abhydrolase domain containing 4 7.29683
DDIT4 DNA-damage-inducible transcript 4 5.33078
BAG3 BCL2-associated athanogene 3 4.86267
PRR15L proline rich 15-like 4.84996
MYLK myosin light chain kinase 4.80733
ADRB2 adrenoceptor beta 2, surface 4.3189
TIAM1 T-cell lymphoma invasion and metastasis 1 4.29884
CBR3 carbonyl reductase 3 4.15935
TXNRD1 thioredoxin reductase 1 4.1587
MSRA methionine sulfoxide reductase A 3.62618
TRIB3 tribbles pseudokinase 3 3.6113
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.46228
CIAO3 cytosolic iron-sulfur assembly component 3 3.45994
UBQLN2 ubiquilin 2 3.40489
HSPA1B heat shock 70kDa protein 1B 3.3146
JADE2 jade family PHD finger 2 3.30267
CARMIL1 capping protein regulator and myosin 1 linker 1 3.2627
NOTCH1 notch 1 3.015
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.94952
KEAP1 kelch-like ECH-associated protein 1 2.92148
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.87897
KIF20A kinesin family member 20A 2.87789
ZNF589 zinc finger protein 589 2.79311
LPAR2 lysophosphatidic acid receptor 2 2.73401
E2F2 E2F transcription factor 2 2.73349
PTK2 protein tyrosine kinase 2 2.72495
PLS1 plastin 1 2.70397
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.68975
COL4A1 collagen, type IV, alpha 1 2.58987
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.57074
CHN1 chimerin 1 2.56817
FCHO1 FCH domain only 1 2.53105
ZNF322 zinc finger protein 322 2.51008
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.5051
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.45028
CHMP6 charged multivesicular body protein 6 2.41389
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.29856
C5 complement component 5 2.28861
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 2.26997
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.23956
BCAS4 breast carcinoma amplified sequence 4 2.23728
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.19845
ELOVL6 ELOVL fatty acid elongase 6 2.19303
ZBTB18 zinc finger and BTB domain containing 18 2.17646
RAB27B RAB27B, member RAS oncogene family 2.13867
SHB Src homology 2 domain containing adaptor protein B 2.13056
PPARG peroxisome proliferator-activated receptor gamma 2.12546
AARS1 alanyl-tRNA synthetase 1 2.12015
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.11145
HOXA10 homeobox A10 2.09856
PMM2 phosphomannomutase 2 2.09156
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.08968
GPATCH2L G patch domain containing 2-like 2.06621
MEST mesoderm specific transcript 2.06047
NCS1 neuronal calcium sensor 1 2.05478
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.04863

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.21425
CCNB2 cyclin B2 -6.37981
LDHD lactate dehydrogenase D -6.31223
ARID5B AT rich interactive domain 5B (MRF1-like) -5.7098
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -5.51266
IER3 immediate early response 3 -4.94651
DUSP6 dual specificity phosphatase 6 -4.93224
SLC35F2 solute carrier family 35, member F2 -4.89896
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.39133
VAT1 vesicle amine transport 1 -4.28183
MRPS2 mitochondrial ribosomal protein S2 -4.24103
OXA1L oxidase (cytochrome c) assembly 1-like -4.23747
UBE3C ubiquitin protein ligase E3C -4.11149
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.7276
CD320 CD320 molecule -3.63553
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.49113
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.01358
FGFR4 fibroblast growth factor receptor 4 -2.79282
STAMBP STAM binding protein -2.73667
ZNF586 zinc finger protein 586 -2.63217
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.63014
CSK c-src tyrosine kinase -2.42748
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.24486
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.23618
GLOD4 glyoxalase domain containing 4 -2.23077
ELAC2 elaC ribonuclease Z 2 -2.22784
NGRN neugrin, neurite outgrowth associated -2.21382
RPIA ribose 5-phosphate isomerase A -2.18806
PGM1 phosphoglucomutase 1 -2.14472
GRWD1 glutamate-rich WD repeat containing 1 -2.12802
DCK deoxycytidine kinase -2.06963
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.0623
PARP2 poly (ADP-ribose) polymerase 2 -2.02502