CRCGN014_HEPG2_3H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN014_HEPG2_3H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8.09521
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.61551
CXCL2 chemokine (C-X-C motif) ligand 2 6.07926
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.95808
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.75092
LCN2 lipocalin 2 5.61704
GPATCH8 G patch domain containing 8 4.69937
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.35595
BACE2 beta-site APP-cleaving enzyme 2 4.28484
CIAO3 cytosolic iron-sulfur assembly component 3 4.14247
HOXA10 homeobox A10 4.03377
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.92034
AMDHD2 amidohydrolase domain containing 2 3.82881
CEP57 centrosomal protein 57kDa 3.73092
MYLK myosin light chain kinase 3.67874
SYNE2 spectrin repeat containing, nuclear envelope 2 3.6768
DDIT4 DNA-damage-inducible transcript 4 3.49098
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.37664
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.24555
EPHB2 EPH receptor B2 3.19397
EVL Enah/Vasp-like 3.17583
AXIN1 axin 1 3.10338
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.03194
FCHO1 FCH domain only 1 2.98807
NOTCH1 notch 1 2.84836
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.81941
JADE2 jade family PHD finger 2 2.77628
CHMP6 charged multivesicular body protein 6 2.65443
RAP1GAP RAP1 GTPase activating protein 2.61195
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.60705
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.5789
CCDC86 coiled-coil domain containing 86 2.52499
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.43968
CYTH1 cytohesin 1 2.35522
SAA2 serum amyloid A2 2.27771
DEFB1 defensin, beta 1 2.20281
ADRB2 adrenoceptor beta 2, surface 2.15669
FOSL1 FOS-like antigen 1 2.13907
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.12941
SCML2 sex comb on midleg-like 2 (Drosophila) 2.11136
ANO1 anoctamin 1, calcium activated chloride channel 2.08178
GLI3 GLI family zinc finger 3 2.06007
GOLM1 golgi membrane protein 1 2.05268
ANKRD49 ankyrin repeat domain 49 2.04735
SSBP2 single-stranded DNA binding protein 2 2.04572
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.03458
INSIG1 insulin induced gene 1 2.0321
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.00885

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -6.52165
CDC20 cell division cycle 20 -6.21667
TM9SF3 transmembrane 9 superfamily member 3 -6.02233
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.79507
SLC35F2 solute carrier family 35, member F2 -5.15575
CAB39 calcium binding protein 39 -4.38978
CCNB2 cyclin B2 -3.99077
ZNF586 zinc finger protein 586 -3.95503
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.66347
AURKB aurora kinase B -3.60816
PCNA proliferating cell nuclear antigen -3.52399
FOXJ3 forkhead box J3 -3.02933
NRIP1 nuclear receptor interacting protein 1 -3.02815
HTRA1 HtrA serine peptidase 1 -2.84225
LOC124907782 dual specificity protein phosphatase 22 -2.83055
TCTN1 tectonic family member 1 -2.77929
WDR7 WD repeat domain 7 -2.61694
CSK c-src tyrosine kinase -2.45199
OXA1L oxidase (cytochrome c) assembly 1-like -2.33098
TICAM1 toll-like receptor adaptor molecule 1 -2.29428
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.26834
AKAP8 A kinase (PRKA) anchor protein 8 -2.25481
TSPAN4 tetraspanin 4 -2.23907
FOS FBJ murine osteosarcoma viral oncogene homolog -2.20166
SFT2D2 SFT2 domain containing 2 -2.17075
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.16428
IRX4 iroquois homeobox 4 -2.14846
ESRP2 epithelial splicing regulatory protein 2 -2.1273
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.10036
FGFR4 fibroblast growth factor receptor 4 -2.08235
MYO1F myosin IF -2.07094
PRAF2 PRA1 domain family, member 2 -2.06688
TRIP13 thyroid hormone receptor interactor 13 -2.058
GPR176 G protein-coupled receptor 176 -2.05676
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.01417
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.00472
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.00363