CRCGN014_HEPG2_3H:C21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitronaphthalene 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN014_HEPG2_3H:C21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TAC4 tachykinin 4 (hemokinin) 4.76261
IDE insulin-degrading enzyme 4.74116
PRKCD protein kinase C, delta 3.96693
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.61583
TXNL4B thioredoxin-like 4B 3.45649
GSTZ1 glutathione S-transferase zeta 1 3.07737
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.00125
MAP7 microtubule-associated protein 7 2.9594
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.74227
SNX7 sorting nexin 7 2.65796
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.56081
TBXA2R thromboxane A2 receptor 2.48263
CHN1 chimerin 1 2.45466
NMD3 NMD3 ribosome export adaptor 2.29162
JADE2 jade family PHD finger 2 2.28618
DIPK1A divergent protein kinase domain 1A 2.21463
MTO1 mitochondrial tRNA translation optimization 1 2.17356
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 2.13087
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.06018
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.00112

decreased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 -7.27381
GNAS GNAS complex locus -4.94089
PEG10 paternally expressed 10 -4.57237
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.54606
TRIB3 tribbles pseudokinase 3 -3.3974
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.26392
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.23618
SCAND1 SCAN domain containing 1 -2.89663
MACF1 microtubule-actin crosslinking factor 1 -2.57097
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.31704
RYR1 ryanodine receptor 1 (skeletal) -2.20522
EGF epidermal growth factor -2.14345
CNN3 calponin 3, acidic -2.11924
PVALB parvalbumin -2.10604
CLDN4 claudin 4 -2.04052
GPC3 glypican 3 -2.03321