CRCGN014_HEPG2_3H:C22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description lithocholic-acid 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

94 genes differentially expressed following the CRCGN014_HEPG2_3H:C22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 7.01907
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.67405
STK10 serine/threonine kinase 10 4.41857
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.25687
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.80025
LPAR2 lysophosphatidic acid receptor 2 3.63218
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.36665
LCN2 lipocalin 2 3.33153
HEBP1 heme binding protein 1 3.1219
CYCS cytochrome c, somatic 3.1018
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.9868
PMM2 phosphomannomutase 2 2.83668
SNX7 sorting nexin 7 2.8137
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.74403
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.74054
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.67376
NPDC1 neural proliferation, differentiation and control, 1 2.62981
CTSD cathepsin D 2.59214
MEST mesoderm specific transcript 2.54797
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.53525
CSK c-src tyrosine kinase 2.49789
UFM1 ubiquitin-fold modifier 1 2.47259
INPP1 inositol polyphosphate-1-phosphatase 2.45524
CCDC85B coiled-coil domain containing 85B 2.43004
TBPL1 TBP-like 1 2.40405
GADD45A growth arrest and DNA-damage-inducible, alpha 2.39054
RNF44 ring finger protein 44 2.3839
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.37164
CHMP6 charged multivesicular body protein 6 2.35697
IER3 immediate early response 3 2.34784
DIPK1A divergent protein kinase domain 1A 2.34171
SMIM40 small integral membrane protein 40 2.33353
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.29983
MOSPD1 motile sperm domain containing 1 2.29224
MAP7 microtubule-associated protein 7 2.28466
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.20326
CCNA1 cyclin A1 2.18449
DUSP8 dual specificity phosphatase 8 2.16374
SORBS3 sorbin and SH3 domain containing 3 2.15007
NOTCH1 notch 1 2.1474
GARRE1 granule associated Rac and RHOG effector 1 2.13732
DOC2A double C2-like domains, alpha 2.10396
RTN2 reticulon 2 2.09416
GHR growth hormone receptor 2.09062
TESK1 testis-specific kinase 1 2.07739
SPATS2 spermatogenesis associated, serine-rich 2 2.07592
CAMTA2 calmodulin binding transcription activator 2 2.06559
MPHOSPH6 M-phase phosphoprotein 6 2.04775
SHB Src homology 2 domain containing adaptor protein B 2.04121
RPP38 ribonuclease P/MRP 38kDa subunit 2.03579
CHN1 chimerin 1 2.03024
TENT4A terminal nucleotidyltransferase 4A 2.02941
CDK7 cyclin-dependent kinase 7 2.02096
C2CD2 C2 calcium-dependent domain containing 2 2.01468
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.01223

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.21316
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.1115
ACAA1 acetyl-CoA acyltransferase 1 -4.75408
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.34852
PECR peroxisomal trans-2-enoyl-CoA reductase -3.84246
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.72834
PRPF4 pre-mRNA processing factor 4 -3.69333
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.68468
CDC25B cell division cycle 25B -3.67787
LDHD lactate dehydrogenase D -3.60494
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.59911
FASTKD5 FAST kinase domains 5 -3.4638
ANKRD10 ankyrin repeat domain 10 -3.36343
NISCH nischarin -3.17081
TLR4 toll-like receptor 4 -3.15656
CDK6 cyclin-dependent kinase 6 -3.11746
CCNB2 cyclin B2 -2.81928
NNT nicotinamide nucleotide transhydrogenase -2.72384
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.65013
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.62818
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.61672
TLCD3A TLC domain containing 3A -2.53782
GNAS GNAS complex locus -2.48105
RSU1 Ras suppressor protein 1 -2.47991
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.44338
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.34152
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.29583
PRPF31 pre-mRNA processing factor 31 -2.2448
SLC35F2 solute carrier family 35, member F2 -2.18559
U2SURP U2 snRNP-associated SURP domain containing -2.13133
SKIC2 SKI2 subunit of superkiller complex -2.11875
PSRC1 proline/serine-rich coiled-coil 1 -2.0885
FOS FBJ murine osteosarcoma viral oncogene homolog -2.08493
KIF14 kinesin family member 14 -2.08275
PARP1 poly (ADP-ribose) polymerase 1 -2.0772
NUP62 nucleoporin 62kDa -2.06983
MTERF3 mitochondrial transcription termination factor 3 -2.05583
MAPK13 mitogen-activated protein kinase 13 -2.02767
PCCB propionyl CoA carboxylase, beta polypeptide -2.01225