CRCGN014_HEPG2_3H:C24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sorbic-acid 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN014_HEPG2_3H:C24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 4.75417
RPP38 ribonuclease P/MRP 38kDa subunit 4.63789
JADE2 jade family PHD finger 2 4.62434
CSK c-src tyrosine kinase 4.195
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.1275
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.80382
MEST mesoderm specific transcript 3.55005
CHN1 chimerin 1 3.37901
MAP7 microtubule-associated protein 7 3.22912
TESK1 testis-specific kinase 1 3.21345
NOSIP nitric oxide synthase interacting protein 2.86793
SFTPB surfactant protein B 2.76242
LAP3 leucine aminopeptidase 3 2.64513
TXNRD1 thioredoxin reductase 1 2.64332
MMP2 matrix metallopeptidase 2 2.61072
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.59089
NIT1 nitrilase 1 2.57121
STIMATE STIM activating enhancer 2.4248
TENT4A terminal nucleotidyltransferase 4A 2.32349
KIF20A kinesin family member 20A 2.31106
UVRAG UV radiation resistance associated 2.29964
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.18082
SNAP29 synaptosomal-associated protein, 29kDa 2.10653
GLRX2 glutaredoxin 2 2.10161
CCP110 centriolar coiled coil protein 110kDa 2.07519
CHEK2 checkpoint kinase 2 2.05378
H2BC21 H2B clustered histone 21 2.04161

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.3965
CCNB2 cyclin B2 -7.18893
CDC20 cell division cycle 20 -5.91508
PRPF4 pre-mRNA processing factor 4 -4.94679
LDHD lactate dehydrogenase D -4.75284
OXA1L oxidase (cytochrome c) assembly 1-like -4.7013
PCNA proliferating cell nuclear antigen -4.66275
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.05055
HEATR1 HEAT repeat containing 1 -3.91104
HSPB1 heat shock 27kDa protein 1 -3.75822
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.66319
STMN1 stathmin 1 -3.47804
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.43612
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.01125
GNAS GNAS complex locus -2.89608
HLA-DMA major histocompatibility complex, class II, DM alpha -2.64646
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.53452
TCTN1 tectonic family member 1 -2.22408
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.09156
PEG10 paternally expressed 10 -2.05817
DCP1A decapping mRNA 1A -2.00171