CRCGN014_HEPG2_3H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description penicillin-v-potassium 20.59 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

104 genes differentially expressed following the CRCGN014_HEPG2_3H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.31899
CYCS cytochrome c, somatic 5.13383
MAP7 microtubule-associated protein 7 5.05401
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.75723
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.22292
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.85924
RPL39L ribosomal protein L39-like 3.85295
E2F2 E2F transcription factor 2 3.55803
UBQLN2 ubiquilin 2 3.48053
TAC4 tachykinin 4 (hemokinin) 3.47109
BZW2 basic leucine zipper and W2 domains 2 3.31906
CBR3 carbonyl reductase 3 3.3133
LOC122526780 uncharacterized LOC122526780 3.20641
CRTAP cartilage associated protein 2.99118
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.98265
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.87144
TBC1D10C TBC1 domain family, member 10C 2.85534
FCHO1 FCH domain only 1 2.85121
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.84398
CSK c-src tyrosine kinase 2.81962
MAMLD1 mastermind-like domain containing 1 2.73288
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.73154
STK10 serine/threonine kinase 10 2.69969
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.58044
ARHGAP1 Rho GTPase activating protein 1 2.51451
GPER1 G protein-coupled estrogen receptor 1 2.513
TRAM2 translocation associated membrane protein 2 2.46891
IQGAP1 IQ motif containing GTPase activating protein 1 2.41604
ANO1 anoctamin 1, calcium activated chloride channel 2.39432
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.3552
ZBTB35 zinc finger and BTB domain containing 35 2.29032
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.23511
MBNL1 muscleblind-like splicing regulator 1 2.2141
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.21191
RTN4 reticulon 4 2.15796
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.14568
MCUR1 mitochondrial calcium uniporter regulator 1 2.10977
PREB prolactin regulatory element binding 2.05813
DCTN1 dynactin 1 2.05091
RANBP6 RAN binding protein 6 2.04643
NUCB2 nucleobindin 2 2.04495
MED23 mediator complex subunit 23 2.03593
NOSIP nitric oxide synthase interacting protein 2.02631
SFTPB surfactant protein B 2.01497
PLSCR3 phospholipid scramblase 3 2.01459
INSIG1 insulin induced gene 1 2.01284

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ITFG1 integrin alpha FG-GAP repeat containing 1 -6.1914
LDHD lactate dehydrogenase D -5.83589
LOC124907782 dual specificity protein phosphatase 22 -5.2011
NGRN neugrin, neurite outgrowth associated -4.63613
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.52834
UBE3C ubiquitin protein ligase E3C -4.48192
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.2488
TRIB3 tribbles pseudokinase 3 -4.23517
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.93281
SPAG4 sperm associated antigen 4 -3.90655
ARID5B AT rich interactive domain 5B (MRF1-like) -3.81428
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -3.75111
CD320 CD320 molecule -3.73001
CCNB2 cyclin B2 -3.72264
TCTN1 tectonic family member 1 -3.45339
FGFR4 fibroblast growth factor receptor 4 -3.38013
CDC20 cell division cycle 20 -3.24184
LAGE3 L antigen family, member 3 -3.07254
TLR4 toll-like receptor 4 -2.99988
ZNF586 zinc finger protein 586 -2.9697
BCL7B B-cell CLL/lymphoma 7B -2.92958
BPHL biphenyl hydrolase-like (serine hydrolase) -2.90406
DUSP6 dual specificity phosphatase 6 -2.80763
AXIN1 axin 1 -2.787
CSAG2 CSAG family, member 2 -2.76329
COG4 component of oligomeric golgi complex 4 -2.727
HMG20B high mobility group 20B -2.70882
NCK1 NCK adaptor protein 1 -2.68267
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.64504
ERI2 ERI1 exoribonuclease family member 2 -2.60002
CDKN2A cyclin-dependent kinase inhibitor 2A -2.57916
HOXB9 homeobox B9 -2.43938
PECR peroxisomal trans-2-enoyl-CoA reductase -2.42007
CBR1 carbonyl reductase 1 -2.34674
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -2.3425
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.33368
MRPS2 mitochondrial ribosomal protein S2 -2.29615
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 -2.28789
BCL2A1 BCL2-related protein A1 -2.28503
PRAF2 PRA1 domain family, member 2 -2.25387
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.24309
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.23183
STC2 stanniocalcin 2 -2.20997
CDX2 caudal type homeobox 2 -2.18902
CTNND1 catenin (cadherin-associated protein), delta 1 -2.12298
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like -2.06801
AGPS alkylglycerone phosphate synthase -2.06197
BTBD1 BTB (POZ) domain containing 1 -2.05222
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.0241
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.0217
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.01543
PALB2 partner and localizer of BRCA2 -2.00686
FAM114A2 family with sequence similarity 114, member A2 -2.00613
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.00558
LOC100533997 MAGEA10-MAGEA5 readthrough -2.00339
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.00336
TWF2 twinfilin actin binding protein 2 -2.00177