CRCGN014_HEPG2_3H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1260 38.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

128 genes differentially expressed following the CRCGN014_HEPG2_3H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 10.0
EGR1 early growth response 1 7.66251
IER3 immediate early response 3 7.41054
ZFP36 ZFP36 ring finger protein 6.70743
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.24734
MYC v-myc avian myelocytomatosis viral oncogene homolog 5.98244
FOSL1 FOS-like antigen 1 5.90503
TRIB1 tribbles pseudokinase 1 5.73693
FOS FBJ murine osteosarcoma viral oncogene homolog 5.55481
JUN jun proto-oncogene 4.97821
CXCL2 chemokine (C-X-C motif) ligand 2 4.72279
MAP7 microtubule-associated protein 7 4.70219
KIFBP kinesin family binding protein 4.6956
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4.61136
CNPY3 canopy FGF signaling regulator 3 4.5764
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.31906
LOC102724023 ES1 protein homolog, mitochondrial 4.22637
UBQLN2 ubiquilin 2 3.98102
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.969
IER2 immediate early response 2 3.93453
KLHL21 kelch-like family member 21 3.83575
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.82062
MYLK myosin light chain kinase 3.74761
NOTCH1 notch 1 3.5452
MPC2 mitochondrial pyruvate carrier 2 3.4264
CIAO3 cytosolic iron-sulfur assembly component 3 3.40187
DUSP6 dual specificity phosphatase 6 3.37047
CSK c-src tyrosine kinase 3.24878
ANO1 anoctamin 1, calcium activated chloride channel 3.22164
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.20927
RPP38 ribonuclease P/MRP 38kDa subunit 3.2022
BHLHE40 basic helix-loop-helix family, member e40 3.18183
EDN1 endothelin 1 3.13911
HSPA1A heat shock 70kDa protein 1A 3.11407
GADD45B growth arrest and DNA-damage-inducible, beta 3.06732
ATF3 activating transcription factor 3 3.03564
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.98275
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.97001
TRIB3 tribbles pseudokinase 3 2.95937
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.8158
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.80768
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.74419
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.73743
HOXA10 homeobox A10 2.62908
KLF6 Kruppel-like factor 6 2.62211
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.61501
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.58964
EGR3 early growth response 3 2.55468
TERT telomerase reverse transcriptase 2.55392
CDKN2AIP CDKN2A interacting protein 2.54899
LOC102724428 serine/threonine-protein kinase SIK1 2.49561
CCNL1 cyclin L1 2.45937
EPHB2 EPH receptor B2 2.41403
KDM3A lysine (K)-specific demethylase 3A 2.35589
ICAM1 intercellular adhesion molecule 1 2.34805
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.34281
VAV3 vav 3 guanine nucleotide exchange factor 2.33549
SQSTM1 sequestosome 1 2.32714
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.29908
CCL2 chemokine (C-C motif) ligand 2 2.29657
NDE1 nudE neurodevelopment protein 1 2.28873
SERTAD2 SERTA domain containing 2 2.24696
CYCS cytochrome c, somatic 2.22046
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.18839
ASCC3 activating signal cointegrator 1 complex subunit 3 2.1762
GSK3B glycogen synthase kinase 3 beta 2.17387
SNAI1 snail family zinc finger 1 2.17214
PMM2 phosphomannomutase 2 2.16513
DUSP2 dual specificity phosphatase 2 2.16403
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.14732
SIRT1 sirtuin 1 2.14691
EPHA2 EPH receptor A2 2.1405
PLK3 polo-like kinase 3 2.12903
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.09538
CLK3 CDC-like kinase 3 2.08308
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 2.05851
FOXJ3 forkhead box J3 2.05644
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.01468

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.80416
ZNF586 zinc finger protein 586 -6.67428
CCDC86 coiled-coil domain containing 86 -4.54128
CDC25B cell division cycle 25B -4.46271
FASTKD5 FAST kinase domains 5 -4.37317
DERA deoxyribose-phosphate aldolase (putative) -4.21788
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -4.13247
BLCAP bladder cancer associated protein -4.08755
FGFR4 fibroblast growth factor receptor 4 -3.77075
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.69493
HAT1 histone acetyltransferase 1 -3.61324
REEP5 receptor accessory protein 5 -3.60514
CCNB2 cyclin B2 -3.55912
ADI1 acireductone dioxygenase 1 -3.49069
MAPK13 mitogen-activated protein kinase 13 -3.10406
SLC35F2 solute carrier family 35, member F2 -3.07173
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.05404
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.01313
CDC20 cell division cycle 20 -2.9543
LOC124907782 dual specificity protein phosphatase 22 -2.93688
GNAS GNAS complex locus -2.90624
TXNDC9 thioredoxin domain containing 9 -2.84214
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.80331
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.71838
COG7 component of oligomeric golgi complex 7 -2.70191
PSRC1 proline/serine-rich coiled-coil 1 -2.65584
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.62741
UBE3C ubiquitin protein ligase E3C -2.54577
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.52205
MPPED2 metallophosphoesterase domain containing 2 -2.51171
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.45255
BRCA1 breast cancer 1, early onset -2.41452
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.35134
TLCD3A TLC domain containing 3A -2.32644
ACAA1 acetyl-CoA acyltransferase 1 -2.32457
NT5DC2 5'-nucleotidase domain containing 2 -2.30107
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.29349
OXA1L oxidase (cytochrome c) assembly 1-like -2.26288
MAT2A methionine adenosyltransferase II, alpha -2.25186
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.1088
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.10856
ZDHHC6 zinc finger, DHHC-type containing 6 -2.10284
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.08528
TMEM109 transmembrane protein 109 -2.06892
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.04748
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.03814
CD320 CD320 molecule -2.03634
UNC119B unc-119 homolog B (C. elegans) -2.01683
THOP1 thimet oligopeptidase 1 -2.01043
FKBP11 FK506 binding protein 11, 19 kDa -2.00153