CRCGN014_HEPG2_3H:D03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 41.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

155 genes differentially expressed following the CRCGN014_HEPG2_3H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 4.61461
E2F2 E2F transcription factor 2 4.60309
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.98897
HSPA1A heat shock 70kDa protein 1A 3.89229
ATP11B ATPase, class VI, type 11B 3.7652
SMIM40 small integral membrane protein 40 3.76436
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.66644
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.64968
RPP38 ribonuclease P/MRP 38kDa subunit 3.61864
IGFBP3 insulin-like growth factor binding protein 3 3.51446
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.47456
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.38266
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.26077
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.21583
TIMP2 TIMP metallopeptidase inhibitor 2 3.16009
NPDC1 neural proliferation, differentiation and control, 1 3.13995
HYOU1 hypoxia up-regulated 1 3.11148
CYCS cytochrome c, somatic 3.06811
PTPRK protein tyrosine phosphatase, receptor type, K 3.01817
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.01531
ALAS1 5'-aminolevulinate synthase 1 2.93813
NVL nuclear VCP-like 2.89067
CTSD cathepsin D 2.79123
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.74762
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.73979
HSF1 heat shock transcription factor 1 2.73909
LPAR2 lysophosphatidic acid receptor 2 2.73562
IL1B interleukin 1, beta 2.71675
ABHD4 abhydrolase domain containing 4 2.69065
SNX7 sorting nexin 7 2.68692
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.68293
CIAO3 cytosolic iron-sulfur assembly component 3 2.67426
PRKX protein kinase, X-linked 2.65482
KIFBP kinesin family binding protein 2.64579
CORO1A coronin, actin binding protein, 1A 2.64028
GSTZ1 glutathione S-transferase zeta 1 2.62101
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.60013
MEST mesoderm specific transcript 2.59033
RAI14 retinoic acid induced 14 2.55009
TESK1 testis-specific kinase 1 2.5386
MAP7 microtubule-associated protein 7 2.53427
TP53 tumor protein p53 2.52262
HEBP1 heme binding protein 1 2.52259
HTRA1 HtrA serine peptidase 1 2.50284
LMX1B LIM homeobox transcription factor 1, beta 2.48901
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.4812
XPO7 exportin 7 2.47527
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.46485
CRABP1 cellular retinoic acid binding protein 1 2.46315
FZD1 frizzled class receptor 1 2.42273
RAB21 RAB21, member RAS oncogene family 2.38521
SYT13 synaptotagmin XIII 2.37353
TRAPPC6A trafficking protein particle complex 6A 2.35431
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 2.34724
WDR46 WD repeat domain 46 2.33616
CSNK1E casein kinase 1, epsilon 2.32726
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.29074
GHR growth hormone receptor 2.26603
HSPA1B heat shock 70kDa protein 1B 2.25546
SHB Src homology 2 domain containing adaptor protein B 2.22021
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.21253
BARX1 BARX homeobox 1 2.19168
LIN28A lin-28 homolog A (C. elegans) 2.1755
DIPK1A divergent protein kinase domain 1A 2.16922
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.16798
ZFP36 ZFP36 ring finger protein 2.16794
CCNA1 cyclin A1 2.16673
TREH trehalase (brush-border membrane glycoprotein) 2.16546
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.14747
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 2.14717
PTK2B protein tyrosine kinase 2 beta 2.14314
NOTCH1 notch 1 2.13085
RAB43 RAB43, member RAS oncogene family 2.12887
ZIC3 Zic family member 3 2.12743
WBP2 WW domain binding protein 2 2.11722
CNOT3 CCR4-NOT transcription complex, subunit 3 2.11039
FKBP8 FK506 binding protein 8, 38kDa 2.10737
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.10007
GLT8D2 glycosyltransferase 8 domain containing 2 2.09327
ITGA8 integrin, alpha 8 2.0823
PLA2G2F phospholipase A2, group IIF 2.08216
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.07746
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.0768
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.07655
NALF2 NALCN channel auxiliary factor 2 2.07245
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.06366
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.05907
SHOX short stature homeobox 2.05872
TERT telomerase reverse transcriptase 2.0538
EFS embryonal Fyn-associated substrate 2.04641
NEU2 sialidase 2 (cytosolic sialidase) 2.04009
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.03909
KMT2D lysine (K)-specific methyltransferase 2D 2.01109
PMP22 peripheral myelin protein 22 2.00624
ECH1 enoyl CoA hydratase 1, peroxisomal 2.0059

decreased expression

Symbol Name Standardized Value
NCK1 NCK adaptor protein 1 -5.4852
GRWD1 glutamate-rich WD repeat containing 1 -4.95724
DCK deoxycytidine kinase -4.69289
FASTKD5 FAST kinase domains 5 -4.58088
LDHD lactate dehydrogenase D -4.26219
PCNA proliferating cell nuclear antigen -4.21581
MRPS16 mitochondrial ribosomal protein S16 -4.08831
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.81761
EIF5 eukaryotic translation initiation factor 5 -3.69253
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.62006
SPAG4 sperm associated antigen 4 -3.50269
CDK6 cyclin-dependent kinase 6 -3.47675
CDC25B cell division cycle 25B -3.37072
ZNF586 zinc finger protein 586 -3.36634
GTF2A2 general transcription factor IIA, 2, 12kDa -3.3064
SLC35F2 solute carrier family 35, member F2 -3.20447
PRPF4 pre-mRNA processing factor 4 -3.05582
NNT nicotinamide nucleotide transhydrogenase -2.91912
ANKRD10 ankyrin repeat domain 10 -2.8946
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.88532
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.83341
CCNB2 cyclin B2 -2.80325
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.7591
GOLT1B golgi transport 1B -2.74593
CASC3 cancer susceptibility candidate 3 -2.74514
ENOPH1 enolase-phosphatase 1 -2.66373
LBR lamin B receptor -2.61707
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.55785
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.51353
EAPP E2F-associated phosphoprotein -2.4959
RHEB Ras homolog enriched in brain -2.48381
NRIP1 nuclear receptor interacting protein 1 -2.40853
MAT2A methionine adenosyltransferase II, alpha -2.30318
ACOT9 acyl-CoA thioesterase 9 -2.2838
TXNRD1 thioredoxin reductase 1 -2.27233
TRIB3 tribbles pseudokinase 3 -2.27221
WDR7 WD repeat domain 7 -2.26598
THAP12 THAP domain containing 12 -2.24473
STK25 serine/threonine kinase 25 -2.23293
FZD7 frizzled class receptor 7 -2.23258
RFC2 replication factor C (activator 1) 2, 40kDa -2.21356
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.18677
PECR peroxisomal trans-2-enoyl-CoA reductase -2.17592
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.14573
RGS2 regulator of G-protein signaling 2 -2.14223
CHUK conserved helix-loop-helix ubiquitous kinase -2.13202
MED28 mediator complex subunit 28 -2.12938
ADI1 acireductone dioxygenase 1 -2.12815
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.12421
SACS sacsin molecular chaperone -2.10815
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.0866
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.06266
GTPBP8 GTP-binding protein 8 (putative) -2.04962
ADAM10 ADAM metallopeptidase domain 10 -2.03824
RSRC1 arginine/serine-rich coiled-coil 1 -2.03571
NISCH nischarin -2.03507
CCNA2 cyclin A2 -2.03156
SMIM10L1 small integral membrane protein 10 like 1 -2.02491
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.023
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.00116