CRCGN014_HEPG2_3H:D04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN014_HEPG2_3H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 8.18625
DDIT4 DNA-damage-inducible transcript 4 6.42821
UBQLN2 ubiquilin 2 6.2379
HOXA5 homeobox A5 5.79146
CBR3 carbonyl reductase 3 5.66589
SFTPB surfactant protein B 5.11138
TXNRD1 thioredoxin reductase 1 4.5769
SQSTM1 sequestosome 1 3.73286
NOSIP nitric oxide synthase interacting protein 3.59872
MCOLN1 mucolipin 1 3.56309
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.54064
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.11602
ABHD6 abhydrolase domain containing 6 3.11356
ABHD4 abhydrolase domain containing 4 3.10108
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.0971
TRIB3 tribbles pseudokinase 3 3.02789
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.00906
E2F2 E2F transcription factor 2 3.00326
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.98459
CXCL2 chemokine (C-X-C motif) ligand 2 2.94913
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.9387
CYCS cytochrome c, somatic 2.89677
LOC122526780 uncharacterized LOC122526780 2.87311
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.86542
EPHB2 EPH receptor B2 2.81093
HSPA1A heat shock 70kDa protein 1A 2.77872
FCHO1 FCH domain only 1 2.7192
C2CD2 C2 calcium-dependent domain containing 2 2.70079
ICAM1 intercellular adhesion molecule 1 2.60112
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.45764
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.34092
HOXA7 homeobox A7 2.33383
ADRB2 adrenoceptor beta 2, surface 2.30402
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.29905
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.2798
UFM1 ubiquitin-fold modifier 1 2.27358
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.2619
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.26042
HOXA4 homeobox A4 2.15582
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.1118
RCOR1 REST corepressor 1 2.08684
TSKU tsukushi, small leucine rich proteoglycan 2.08401
NUCB2 nucleobindin 2 2.05753
GOLT1B golgi transport 1B 2.00409

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
LDHD lactate dehydrogenase D -7.11348
MRPS2 mitochondrial ribosomal protein S2 -4.44612
CDC25B cell division cycle 25B -4.06187
ZNF586 zinc finger protein 586 -3.76333
CCNB2 cyclin B2 -3.25423
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.20535
TLR4 toll-like receptor 4 -3.12628
NT5DC2 5'-nucleotidase domain containing 2 -3.01086
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.8228
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.7818
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.74645
SNX11 sorting nexin 11 -2.73991
STX4 syntaxin 4 -2.60259
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.4613
FANCI Fanconi anemia, complementation group I -2.32761
OXA1L oxidase (cytochrome c) assembly 1-like -2.32366
CALML4 calmodulin-like 4 -2.16354
NCALD neurocalcin delta -2.1435
CAPN15 calpain 15 -2.13658
DUSP6 dual specificity phosphatase 6 -2.09552
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.05681
CSK c-src tyrosine kinase -2.03418
IPO13 importin 13 -2.02728