CRCGN014_HEPG2_3H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description paracetamol 41.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN014_HEPG2_3H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.5105
CCL2 chemokine (C-C motif) ligand 2 5.08225
CSK c-src tyrosine kinase 4.8983
CCDC92 coiled-coil domain containing 92 4.8857
PPARG peroxisome proliferator-activated receptor gamma 4.7186
CGRRF1 cell growth regulator with ring finger domain 1 4.701
ABHD6 abhydrolase domain containing 6 4.66948
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.58165
CXCL2 chemokine (C-X-C motif) ligand 2 4.55335
CBR3 carbonyl reductase 3 4.5174
SNAP25 synaptosomal-associated protein, 25kDa 4.43108
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.31915
HDGFL3 HDGF like 3 4.09487
MAP7 microtubule-associated protein 7 4.01763
TIAM1 T-cell lymphoma invasion and metastasis 1 3.6613
DIPK1A divergent protein kinase domain 1A 3.62813
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.5849
TEX10 testis expressed 10 3.22915
CYCS cytochrome c, somatic 3.16365
TLR4 toll-like receptor 4 3.1273
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 3.05655
ATP5MC1 ATP synthase membrane subunit c locus 1 2.69425
GPATCH8 G patch domain containing 8 2.48333
KIF14 kinesin family member 14 2.35535
CRCT1 cysteine-rich C-terminal 1 2.3389
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.3346
SOCS2 suppressor of cytokine signaling 2 2.32518
KRT6B keratin 6B, type II 2.2965
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.28145
DSG1 desmoglein 1 2.2717
CKMT1A creatine kinase, mitochondrial 1A 2.26925
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 2.26201
TGM1 transglutaminase 1 2.25935
SPRR2B small proline-rich protein 2B 2.2575
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.2569
CSTA cystatin A (stefin A) 2.23835
BMP4 bone morphogenetic protein 4 2.21195
TBP TATA box binding protein 2.20955
ANAPC10 anaphase promoting complex subunit 10 2.1926
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.1921
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 2.1413
SLURP1 secreted LY6/PLAUR domain containing 1 2.12415
COQ8A coenzyme Q8A 2.11475
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 2.10395
KLK6 kallikrein-related peptidase 6 2.10092
BLTP3B bridge-like lipid transfer protein family member 3B 2.09995
IGFBP4 insulin-like growth factor binding protein 4 2.08885
LY6D lymphocyte antigen 6 complex, locus D 2.08165
CHN1 chimerin 1 2.0753
MYOT myotilin 2.0503
FCHO1 FCH domain only 1 2.047
DDR2 discoidin domain receptor tyrosine kinase 2 2.04255
BMAL2 basic helix-loop-helix ARNT like 2 2.04195
VSNL1 visinin-like 1 2.0383
ASPA aspartoacylase 2.03355
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.0209
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.01108

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.67579
ITFG1 integrin alpha FG-GAP repeat containing 1 -6.14095
ZNF586 zinc finger protein 586 -4.78265
KDM3A lysine (K)-specific demethylase 3A -4.67955
CCNB2 cyclin B2 -4.66275
FGFR4 fibroblast growth factor receptor 4 -3.9432
NGRN neugrin, neurite outgrowth associated -3.83885
FBXL12 F-box and leucine-rich repeat protein 12 -3.4844
EIF5 eukaryotic translation initiation factor 5 -3.36672
CCNB1 cyclin B1 -3.31745
TXNDC9 thioredoxin domain containing 9 -3.13693
OXA1L oxidase (cytochrome c) assembly 1-like -2.9395
S1PR4 sphingosine-1-phosphate receptor 4 -2.61345
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.5752
RASL11B RAS-like, family 11, member B -2.54185
TWF2 twinfilin actin binding protein 2 -2.50985
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.50155
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.3146
APIP APAF1 interacting protein -2.2901
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.2487
PRPF4 pre-mRNA processing factor 4 -2.2044
TRIM24 tripartite motif containing 24 -2.1883
LITAF lipopolysaccharide-induced TNF factor -2.15642
MPC2 mitochondrial pyruvate carrier 2 -2.13955
PCDH8 protocadherin 8 -2.07975
FAM114A1 family with sequence similarity 114, member A1 -2.0761
MAP9 microtubule-associated protein 9 -2.0665
PLAAT1 phospholipase A and acyltransferase 1 -2.05175
RNF103 ring finger protein 103 -2.003