CRCGN014_HEPG2_3H:D08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloro-p-phenylenediamine sulfate 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

118 genes differentially expressed following the CRCGN014_HEPG2_3H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 7.28823
PNKP polynucleotide kinase 3'-phosphatase 6.67651
ATP11B ATPase, class VI, type 11B 5.89541
EGR1 early growth response 1 5.24024
MAP7 microtubule-associated protein 7 4.82704
MAMLD1 mastermind-like domain containing 1 4.37984
JUN jun proto-oncogene 4.20037
MOK MOK protein kinase 4.19813
JADE2 jade family PHD finger 2 4.12604
CIAO3 cytosolic iron-sulfur assembly component 3 3.95523
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.71084
EPN2 epsin 2 3.58772
ZFP36 ZFP36 ring finger protein 3.54806
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.54337
ZNF589 zinc finger protein 589 3.53882
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.52057
GADD45B growth arrest and DNA-damage-inducible, beta 3.44545
HSPA1A heat shock 70kDa protein 1A 3.1573
MINDY1 MINDY lysine 48 deubiquitinase 1 3.13207
FOSL1 FOS-like antigen 1 3.11222
SSBP2 single-stranded DNA binding protein 2 3.09856
FCHO1 FCH domain only 1 3.06732
PEX11A peroxisomal biogenesis factor 11 alpha 3.02144
CDPF1 cysteine-rich, DPF motif domain containing 1 2.99603
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.97826
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.96985
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.94046
CAPN1 calpain 1, (mu/I) large subunit 2.92619
HOXA10 homeobox A10 2.87412
KRT2 keratin 2, type II 2.79145
AMDHD2 amidohydrolase domain containing 2 2.75709
GADD45A growth arrest and DNA-damage-inducible, alpha 2.64308
KCNK5 potassium channel, two pore domain subfamily K, member 5 2.6398
KIF20A kinesin family member 20A 2.61458
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.61039
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.60883
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.58755
LCN2 lipocalin 2 2.55437
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.52935
PPARG peroxisome proliferator-activated receptor gamma 2.50105
TRIB1 tribbles pseudokinase 1 2.47932
DIPK1A divergent protein kinase domain 1A 2.43605
CYTH2 cytohesin 2 2.43074
GATA3 GATA binding protein 3 2.42919
LCE2B late cornified envelope 2B 2.42394
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.38777
DMTF1 cyclin D binding myb-like transcription factor 1 2.37865
PLK3 polo-like kinase 3 2.36251
IER3 immediate early response 3 2.35507
LORICRIN loricrin cornified envelope precursor protein 2.35367
CTC1 CTS telomere maintenance complex component 1 2.32784
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.31814
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.30415
DUSP4 dual specificity phosphatase 4 2.2828
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.25216
VGLL4 vestigial-like family member 4 2.20916
DOC2A double C2-like domains, alpha 2.20891
STIMATE STIM activating enhancer 2.19924
INTS3 integrator complex subunit 3 2.17299
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.16799
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.15914
IL37 interleukin 37 2.15829
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.12272
DUSP6 dual specificity phosphatase 6 2.11595
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.03709
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.02878
SCRN1 secernin 1 2.02749
TREX2 three prime repair exonuclease 2 2.01847

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -5.23031
GNAS GNAS complex locus -4.9467
C2CD5 C2 calcium-dependent domain containing 5 -4.02382
CD320 CD320 molecule -4.0083
CDK4 cyclin-dependent kinase 4 -3.92622
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.67972
LDHD lactate dehydrogenase D -3.66922
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.63436
CCNB1 cyclin B1 -3.43778
THAP11 THAP domain containing 11 -3.42526
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.37414
NRIP1 nuclear receptor interacting protein 1 -3.09687
CDC25B cell division cycle 25B -2.93314
TCTN1 tectonic family member 1 -2.87795
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.87558
DNM1L dynamin 1-like -2.81984
SLC35F2 solute carrier family 35, member F2 -2.80503
CHMP4B charged multivesicular body protein 4B -2.77303
FASTKD5 FAST kinase domains 5 -2.76062
CDK6 cyclin-dependent kinase 6 -2.69334
ZNF586 zinc finger protein 586 -2.66792
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.65748
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.63248
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.54706
RPP38 ribonuclease P/MRP 38kDa subunit -2.52186
CCNB2 cyclin B2 -2.49456
CSK c-src tyrosine kinase -2.44541
RELN reelin -2.44006
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.41967
TMEM51 transmembrane protein 51 -2.41357
EIF5 eukaryotic translation initiation factor 5 -2.39411
PROS1 protein S (alpha) -2.33639
MAPK13 mitogen-activated protein kinase 13 -2.31426
CD63 CD63 molecule -2.2804
HDAC2 histone deacetylase 2 -2.23483
BPIFA1 BPI fold containing family A, member 1 -2.233
KRT13 keratin 13, type I -2.22822
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.14699
STAT1 signal transducer and activator of transcription 1, 91kDa -2.12436
ZMIZ1 zinc finger, MIZ-type containing 1 -2.11175
TUBA1B tubulin, alpha 1b -2.10058
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.09906
CAB39 calcium binding protein 39 -2.0932
KRT4 keratin 4, type II -2.06066
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.0605
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -2.04672
MFAP4 microfibrillar-associated protein 4 -2.03688
DNAAF5 dynein, axonemal, assembly factor 5 -2.03479
MSX1 msh homeobox 1 -2.0237
KDM3A lysine (K)-specific demethylase 3A -2.02166