CRCGN014_HEPG2_3H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 40.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN014_HEPG2_3H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.12786
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.11437
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0544
STIMATE STIM activating enhancer 4.73168
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.51804
BACE2 beta-site APP-cleaving enzyme 2 3.29042
HOXA10 homeobox A10 2.92652
SFTPB surfactant protein B 2.88072
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.56418
CHN1 chimerin 1 2.55656
CCNF cyclin F 2.52429
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.50168
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.48099
MEST mesoderm specific transcript 2.39301
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.1741
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 2.08789
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.07768
MAP7 microtubule-associated protein 7 2.07493
PRKCH protein kinase C, eta 2.07435
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 2.02601

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.48938
LDHD lactate dehydrogenase D -8.401
ZNF586 zinc finger protein 586 -5.38325
CCNB2 cyclin B2 -4.82691
THAP11 THAP domain containing 11 -4.68259
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.25271
CDC20 cell division cycle 20 -3.11396
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.99176
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.40413
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.1549
PRPF4 pre-mRNA processing factor 4 -2.09821