CRCGN014_HEPG2_3H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mitoxantrone 20.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

178 genes differentially expressed following the CRCGN014_HEPG2_3H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.59297
MAP7 microtubule-associated protein 7 5.51137
GSTZ1 glutathione S-transferase zeta 1 5.47514
ANO1 anoctamin 1, calcium activated chloride channel 4.81232
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.67557
PNKP polynucleotide kinase 3'-phosphatase 4.46604
CIAO3 cytosolic iron-sulfur assembly component 3 4.25827
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.77103
EPN2 epsin 2 3.4154
STIMATE STIM activating enhancer 3.40183
USP6NL USP6 N-terminal like 3.35398
GPER1 G protein-coupled estrogen receptor 1 3.26061
PRCP prolylcarboxypeptidase (angiotensinase C) 3.22935
HEBP1 heme binding protein 1 3.22506
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.09893
CXCL2 chemokine (C-X-C motif) ligand 2 3.01135
SULF1 sulfatase 1 2.72548
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.71795
CHN1 chimerin 1 2.68443
TRAP1 TNF receptor-associated protein 1 2.61267
THOC6 THO complex 6 2.5252
NECTIN4 nectin cell adhesion molecule 4 2.50596
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.47147
FKBP14 FK506 binding protein 14, 22 kDa 2.44611
INTS3 integrator complex subunit 3 2.42902
CYCS cytochrome c, somatic 2.42899
MSRA methionine sulfoxide reductase A 2.42357
COPS7B COP9 signalosome subunit 7B 2.41733
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.39862
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 2.3891
SLC75A1 solute carrier family 75 member 1 2.37192
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 2.33959
CHMP6 charged multivesicular body protein 6 2.30912
KIF26B kinesin family member 26B 2.30173
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 2.28394
CCNA1 cyclin A1 2.27965
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.27623
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.27123
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.26084
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.26071
HOXC10 homeobox C10 2.25521
TNNT3 troponin T type 3 (skeletal, fast) 2.25491
ANO10 anoctamin 10 2.22039
GARRE1 granule associated Rac and RHOG effector 1 2.2166
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.18172
PROCR protein C receptor, endothelial 2.16533
SCRN1 secernin 1 2.15548
PPP4C protein phosphatase 4, catalytic subunit 2.15057
FGF20 fibroblast growth factor 20 2.14768
GET1 guided entry of tail-anchored proteins factor 1 2.14058
DYNLT3 dynein, light chain, Tctex-type 3 2.1338
HOXC4 homeobox C4 2.13004
UBL5 ubiquitin-like 5 2.12711
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.11908
MEGF6 multiple EGF-like-domains 6 2.11087
MRPL48 mitochondrial ribosomal protein L48 2.10465
MACROD1 MACRO domain containing 1 2.10251
DUSP28 dual specificity phosphatase 28 2.10133
NBAS neuroblastoma amplified sequence 2.09658
DPY19L4 dpy-19-like 4 (C. elegans) 2.08813
POLL polymerase (DNA directed), lambda 2.08693
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.08192
VPS35L VPS35 endosomal protein sorting factor like 2.07972
ITGA8 integrin, alpha 8 2.07809
HPGDS hematopoietic prostaglandin D synthase 2.05952
NPDC1 neural proliferation, differentiation and control, 1 2.05452
NUP133 nucleoporin 133kDa 2.05221
ARL8B ADP-ribosylation factor-like 8B 2.04676
CHMP2A charged multivesicular body protein 2A 2.03384
FAM204A family with sequence similarity 204, member A 2.03028
DNAH7 dynein, axonemal, heavy chain 7 2.02709
FAM149A family with sequence similarity 149, member A 2.02324
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.01894
PRELID3A PRELI domain containing 3A 2.01832
TEX10 testis expressed 10 2.01823
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 2.00261

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -10.0
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -10.0
MYC v-myc avian myelocytomatosis viral oncogene homolog -10.0
IER3 immediate early response 3 -8.83856
CCNB2 cyclin B2 -8.28319
TRIB1 tribbles pseudokinase 1 -7.67643
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -7.14744
RPP38 ribonuclease P/MRP 38kDa subunit -6.37517
UBE3C ubiquitin protein ligase E3C -5.91927
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -5.85937
DDIT4 DNA-damage-inducible transcript 4 -5.75144
CASP3 caspase 3, apoptosis-related cysteine peptidase -5.56615
LDHD lactate dehydrogenase D -5.52784
ARID5B AT rich interactive domain 5B (MRF1-like) -5.23294
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.58026
MRPS2 mitochondrial ribosomal protein S2 -4.55351
DUSP6 dual specificity phosphatase 6 -4.49101
CDK7 cyclin-dependent kinase 7 -3.90135
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.84711
RFC2 replication factor C (activator 1) 2, 40kDa -3.81226
TBPL1 TBP-like 1 -3.70219
UGDH UDP-glucose 6-dehydrogenase -3.69395
FOSL1 FOS-like antigen 1 -3.66059
TUBB6 tubulin, beta 6 class V -3.61888
KLHL21 kelch-like family member 21 -3.55938
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.50611
CDC25B cell division cycle 25B -3.39493
ZW10 zw10 kinetochore protein -3.3775
ZBTB35 zinc finger and BTB domain containing 35 -3.36422
SMG8 SMG8 nonsense mediated mRNA decay factor -3.33799
TXNRD1 thioredoxin reductase 1 -3.21674
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.20513
MAD2L1BP MAD2L1 binding protein -3.16312
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.09662
NCK1 NCK adaptor protein 1 -3.08876
GCC1 GRIP and coiled-coil domain containing 1 -3.07603
KEAP1 kelch-like ECH-associated protein 1 -3.02049
TXLNA taxilin alpha -3.0159
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.97557
ZNF586 zinc finger protein 586 -2.96395
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.83538
CGRRF1 cell growth regulator with ring finger domain 1 -2.80787
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.79958
TRIM13 tripartite motif containing 13 -2.73264
BCL10 B-cell CLL/lymphoma 10 -2.68646
TLR4 toll-like receptor 4 -2.68325
UBAP1 ubiquitin associated protein 1 -2.64606
RGS2 regulator of G-protein signaling 2 -2.64393
ZNF267 zinc finger protein 267 -2.63135
IP6K2 inositol hexakisphosphate kinase 2 -2.5672
ZNF7 zinc finger protein 7 -2.56098
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.51269
KLHL9 kelch-like family member 9 -2.51075
BIRC2 baculoviral IAP repeat containing 2 -2.50592
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.49055
HOXA5 homeobox A5 -2.46844
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.45047
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.42266
CSK c-src tyrosine kinase -2.41357
PNRC1 proline-rich nuclear receptor coactivator 1 -2.3745
FBXO34 F-box protein 34 -2.35615
TRIB3 tribbles pseudokinase 3 -2.35001
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.34586
ZNF443 zinc finger protein 443 -2.34177
TBCC tubulin folding cofactor C -2.32522
NRBF2 nuclear receptor binding factor 2 -2.30231
GTF2B general transcription factor IIB -2.29636
PLAGL2 pleiomorphic adenoma gene-like 2 -2.28468
GNAS GNAS complex locus -2.25732
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.2465
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.23767
MIS12 MIS12 kinetochore complex component -2.19499
SQSTM1 sequestosome 1 -2.19067
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.18208
AHR aryl hydrocarbon receptor -2.17618
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.17564
FAM53C family with sequence similarity 53, member C -2.17028
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.1674
EGR1 early growth response 1 -2.16045
ZNF16 zinc finger protein 16 -2.15898
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.15185
RAP1GAP RAP1 GTPase activating protein -2.14164
MIURF mitochondrial elongation factor 1 upstream open reading frame -2.12846
GEMIN4 gem (nuclear organelle) associated protein 4 -2.09639
ZNF574 zinc finger protein 574 -2.08273
ZNF518A zinc finger protein 518A -2.0613
OGN osteoglycin -2.05816
PCCB propionyl CoA carboxylase, beta polypeptide -2.05727
KYNU kynureninase -2.0562
GGNBP2 gametogenetin binding protein 2 -2.05605
TSC22D1 TSC22 domain family, member 1 -2.05553
NKAPD1 NKAP domain containing 1 -2.04234
CYREN cell cycle regulator of NHEJ -2.0381
ZNF212 zinc finger protein 212 -2.03034
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.02726
RAB9A RAB9A, member RAS oncogene family -2.02458
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.02064
NUP62 nucleoporin 62kDa -2.01657
PNRC2 proline-rich nuclear receptor coactivator 2 -2.01103
ASTE1 asteroid homolog 1 (Drosophila) -2.00998
JRKL JRK-like -2.00504
EGR3 early growth response 3 -2.0012