CRCGN014_HEPG2_3H:D18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate 20.25 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN014_HEPG2_3H:D18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 6.77386
MAP7 microtubule-associated protein 7 5.55704
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.94954
PRR15L proline rich 15-like 4.87213
C2CD2 C2 calcium-dependent domain containing 2 3.83163
CYCS cytochrome c, somatic 3.61699
DIPK1A divergent protein kinase domain 1A 3.55795
GPER1 G protein-coupled estrogen receptor 1 3.55325
PPARG peroxisome proliferator-activated receptor gamma 3.01875
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.60235
HYOU1 hypoxia up-regulated 1 2.41641
HAT1 histone acetyltransferase 1 2.40557
SLC25A46 solute carrier family 25, member 46 2.3235
LCN2 lipocalin 2 2.26983
PREPL prolyl endopeptidase-like 2.22873
CCDC85B coiled-coil domain containing 85B 2.16323
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.15505
LAGE3 L antigen family, member 3 2.13621
ARID4B AT rich interactive domain 4B (RBP1-like) 2.0129

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.43686
PCNA proliferating cell nuclear antigen -5.29992
TLR4 toll-like receptor 4 -5.14204
ZNF586 zinc finger protein 586 -4.97227
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.57323
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.97481
TUBB6 tubulin, beta 6 class V -3.82493
GNAS GNAS complex locus -3.37769
ANKRD10 ankyrin repeat domain 10 -3.26893
LDHD lactate dehydrogenase D -3.12408
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.94449
OXA1L oxidase (cytochrome c) assembly 1-like -2.8528
CTSD cathepsin D -2.81432
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.72526
NVL nuclear VCP-like -2.45727
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.39668
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.38716
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.37402
CARD8 caspase recruitment domain family, member 8 -2.15877
CD53 CD53 molecule -2.15331