CRCGN014_HEPG2_3H:D20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 9-ethyl-9h-carbazol-3-amine hydrochloride 20.26 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN014_HEPG2_3H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 9.38162
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.25139
CCL2 chemokine (C-C motif) ligand 2 7.1178
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.49748
CASP10 caspase 10, apoptosis-related cysteine peptidase 4.38939
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.25169
CXCL2 chemokine (C-X-C motif) ligand 2 3.98479
ANO1 anoctamin 1, calcium activated chloride channel 3.67123
GPER1 G protein-coupled estrogen receptor 1 3.44271
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.25072
STIMATE STIM activating enhancer 3.2296
VENTX VENT homeobox 2.68438
MEST mesoderm specific transcript 2.59861
TAC4 tachykinin 4 (hemokinin) 2.59667
BZW2 basic leucine zipper and W2 domains 2 2.58964
HSPA1A heat shock 70kDa protein 1A 2.57789
PLA2G2E phospholipase A2, group IIE 2.49655
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.44178
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.42228
MMP24 matrix metallopeptidase 24 (membrane-inserted) 2.40112
CD38 CD38 molecule 2.39951
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.39414
CDC45 cell division cycle 45 2.38309
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.3587
SCYL3 SCY1-like 3 (S. cerevisiae) 2.3526
AVPR1B arginine vasopressin receptor 1B 2.33652
SOX18 SRY (sex determining region Y)-box 18 2.33091
ACVRL1 activin A receptor type II-like 1 2.2985
SSX5 synovial sarcoma, X breakpoint 5 2.2775
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.27427
SOCS2 suppressor of cytokine signaling 2 2.26929
XKR8 XK, Kell blood group complex subunit-related family, member 8 2.23712
JMJD4 jumonji domain containing 4 2.22576
WNT1 wingless-type MMTV integration site family, member 1 2.20935
LPAR6 lysophosphatidic acid receptor 6 2.20705
RXRG retinoid X receptor, gamma 2.19225
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.17966
PRDM12 PR domain containing 12 2.17436
ELSPBP1 epididymal sperm binding protein 1 2.17206
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.16552
AMBRA1 autophagy/beclin-1 regulator 1 2.16373
HKDC1 hexokinase domain containing 1 2.16323
XPA xeroderma pigmentosum, complementation group A 2.15154
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.14064
TPO thyroid peroxidase 2.123
SLC68A1 solute carrier family 68 member 1 2.12156
DENND10 DENN domain containing 10 2.11974
CCKAR cholecystokinin A receptor 2.11502
KRT14 keratin 14, type I 2.11211
FAM124B family with sequence similarity 124B 2.0895
SATB1 SATB homeobox 1 2.07212
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.06352
TCL1B T-cell leukemia/lymphoma 1B 2.03561
KLHL9 kelch-like family member 9 2.01903

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -9.40054
ADI1 acireductone dioxygenase 1 -4.95754
TLR4 toll-like receptor 4 -4.72741
CDC20 cell division cycle 20 -4.67061
CCDC86 coiled-coil domain containing 86 -4.38635
CCNB2 cyclin B2 -4.18204
MAPK13 mitogen-activated protein kinase 13 -4.11253
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.84833
NGRN neugrin, neurite outgrowth associated -3.23756
HLA-DMA major histocompatibility complex, class II, DM alpha -3.20526
GNAS GNAS complex locus -3.03973
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.02197
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.95375
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.41857
TEAD3 TEA domain family member 3 -2.35829
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.30951
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.30812
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.30212
EIF5 eukaryotic translation initiation factor 5 -2.24184
TMEM230 transmembrane protein 230 -2.23518
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.15944
GORASP1 golgi reassembly stacking protein 1, 65kDa -2.12553
CCDC15 coiled-coil domain containing 15 -2.08841
ZNF165 zinc finger protein 165 -2.06897
MEA1 male-enhanced antigen 1 -2.06667
CST1 cystatin SN -2.05025
LTBP1 latent transforming growth factor beta binding protein 1 -2.03203
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.03032
MEX3C mex-3 RNA binding family member C -2.01728