CRCGN014_HEPG2_3H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN014_HEPG2_3H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.40944
KDM3A lysine (K)-specific demethylase 3A 5.3255
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 4.81936
MAP7 microtubule-associated protein 7 4.81812
CIAO3 cytosolic iron-sulfur assembly component 3 4.7016
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.61938
DDIT4 DNA-damage-inducible transcript 4 4.56359
MSRA methionine sulfoxide reductase A 4.44016
AMDHD2 amidohydrolase domain containing 2 4.08045
CXCL2 chemokine (C-X-C motif) ligand 2 4.07677
SKIC8 SKI8 subunit of superkiller complex 3.6128
TXNRD1 thioredoxin reductase 1 3.5186
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.49332
PMM2 phosphomannomutase 2 3.43678
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.37826
TWF2 twinfilin actin binding protein 2 3.2039
CHN1 chimerin 1 3.19084
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 3.16326
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.10507
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.03343
PLSCR3 phospholipid scramblase 3 2.93461
KIFBP kinesin family binding protein 2.84667
ZNF589 zinc finger protein 589 2.8034
SNAP25 synaptosomal-associated protein, 25kDa 2.62497
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.58106
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.5414
HYOU1 hypoxia up-regulated 1 2.51137
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.38559
SFTPB surfactant protein B 2.25066
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.24735
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.22206
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.2039
MEST mesoderm specific transcript 2.16061
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.12712
TLR4 toll-like receptor 4 2.10332
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.09619
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.05314
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.04774
TSC1 tuberous sclerosis 1 2.04193
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.03327
TUBGCP5 tubulin, gamma complex associated protein 5 2.02505
NT5C 5', 3'-nucleotidase, cytosolic 2.01857

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.55114
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.51516
CCNB2 cyclin B2 -8.26933
GNAS GNAS complex locus -6.36836
PCNA proliferating cell nuclear antigen -4.30271
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.18574
NRIP1 nuclear receptor interacting protein 1 -4.15583
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.81402
FGFR4 fibroblast growth factor receptor 4 -3.72957
HEATR1 HEAT repeat containing 1 -3.52402
CCNH cyclin H -3.20065
PECR peroxisomal trans-2-enoyl-CoA reductase -3.18999
CAB39 calcium binding protein 39 -2.99294
ZNF586 zinc finger protein 586 -2.92059
CSK c-src tyrosine kinase -2.84142
TLCD3A TLC domain containing 3A -2.65422
TXNDC9 thioredoxin domain containing 9 -2.34946
CHODL chondrolectin -2.2617
PSIP1 PC4 and SFRS1 interacting protein 1 -2.22275
CETN3 centrin, EF-hand protein, 3 -2.18256
PRR5L proline rich 5 like -2.15022
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.12971
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.11501
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.10144
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -2.1007
CCNB1 cyclin B1 -2.08374
SLC35F2 solute carrier family 35, member F2 -2.05246
SPAG4 sperm associated antigen 4 -2.02878
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.02207
RPL38 ribosomal protein L38 -2.00475
NXPE4 neurexophilin and PC-esterase domain family, member 4 -2.00429