CRCGN014_HEPG2_3H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methapyrilene 20.82 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN014_HEPG2_3H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 7.30097
TIAM1 T-cell lymphoma invasion and metastasis 1 6.85686
ANO1 anoctamin 1, calcium activated chloride channel 6.78247
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.96049
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.82778
LCN2 lipocalin 2 5.45534
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.13483
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.77347
PEX11A peroxisomal biogenesis factor 11 alpha 3.71228
CSK c-src tyrosine kinase 3.54817
GAA glucosidase, alpha; acid 3.50957
E2F2 E2F transcription factor 2 3.43372
MYLK myosin light chain kinase 3.37586
EPHB2 EPH receptor B2 3.27878
TXNL4B thioredoxin-like 4B 3.26601
CARMIL1 capping protein regulator and myosin 1 linker 1 3.08612
ADGRE5 adhesion G protein-coupled receptor E5 3.05314
PPARG peroxisome proliferator-activated receptor gamma 2.937
EPHA3 EPH receptor A3 2.86147
TAC4 tachykinin 4 (hemokinin) 2.76854
PLSCR1 phospholipid scramblase 1 2.68479
MAMLD1 mastermind-like domain containing 1 2.6846
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.62116
COPS7A COP9 signalosome subunit 7A 2.61232
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.57086
SNAP25 synaptosomal-associated protein, 25kDa 2.53203
RYR3 ryanodine receptor 3 2.45727
CCNF cyclin F 2.39042
RRAGA Ras-related GTP binding A 2.31018
SATB1 SATB homeobox 1 2.20317
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.14773
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.13096
GPATCH8 G patch domain containing 8 2.09456
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.09175
ANPEP alanyl (membrane) aminopeptidase 2.01076

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.69016
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.74357
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.64687
DNM1L dynamin 1-like -3.56429
GRWD1 glutamate-rich WD repeat containing 1 -3.40803
AARS1 alanyl-tRNA synthetase 1 -3.21903
TSPAN4 tetraspanin 4 -3.16912
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.00813
MRPS16 mitochondrial ribosomal protein S16 -2.93623
GNAS GNAS complex locus -2.79434
BPHL biphenyl hydrolase-like (serine hydrolase) -2.69795
NRIP1 nuclear receptor interacting protein 1 -2.61147
TXNDC9 thioredoxin domain containing 9 -2.56933
ZMIZ1 zinc finger, MIZ-type containing 1 -2.44902
TLR4 toll-like receptor 4 -2.301
LDHD lactate dehydrogenase D -2.26011
TIPRL TOR signaling pathway regulator -2.12825
TGFB3 transforming growth factor, beta 3 -2.10194
SSTR3 somatostatin receptor 3 -2.1002
PRELID3B PRELI domain containing 3B -2.06436
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.06363
ARMC6 armadillo repeat containing 6 -2.03154
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.00851