CRCGN014_HEPG2_3H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN014_HEPG2_3H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 7.45666
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.56738
GPER1 G protein-coupled estrogen receptor 1 4.28516
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.20174
PEX11A peroxisomal biogenesis factor 11 alpha 3.97826
UBQLN2 ubiquilin 2 3.54724
STIMATE STIM activating enhancer 3.30215
CCDC92 coiled-coil domain containing 92 3.20642
CDK19 cyclin-dependent kinase 19 3.07761
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.00387
MAP7 microtubule-associated protein 7 2.67833
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.62749
VAV3 vav 3 guanine nucleotide exchange factor 2.46238
MOK MOK protein kinase 2.41411
CCL2 chemokine (C-C motif) ligand 2 2.40655
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.28893
BMP4 bone morphogenetic protein 4 2.23816
PRR15L proline rich 15-like 2.21876
BZW2 basic leucine zipper and W2 domains 2 2.11178

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.59254
GNAS GNAS complex locus -5.23967
OXA1L oxidase (cytochrome c) assembly 1-like -4.65838
ZNF586 zinc finger protein 586 -4.15682
LAP3 leucine aminopeptidase 3 -3.93779
MRPS2 mitochondrial ribosomal protein S2 -3.16963
LDHD lactate dehydrogenase D -3.0063
DNM1L dynamin 1-like -2.92558
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.92421
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.86604
CD320 CD320 molecule -2.64566
CDC20 cell division cycle 20 -2.62698
CCNB2 cyclin B2 -2.58505
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.56082
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.48754
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.40271
CHMP4B charged multivesicular body protein 4B -2.33586
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.25194
ADI1 acireductone dioxygenase 1 -2.21285
MCC mutated in colorectal cancers -2.11441
TRIM24 tripartite motif containing 24 -2.01323
DNAH3 dynein, axonemal, heavy chain 3 -2.00315