CRCGN014_HEPG2_3H:E06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibutyltin diacetate 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN014_HEPG2_3H:E06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 9.84328
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 7.69076
BAG3 BCL2-associated athanogene 3 7.47617
FRS2 fibroblast growth factor receptor substrate 2 5.18525
HMOX1 heme oxygenase 1 4.70178
CYCS cytochrome c, somatic 4.61752
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 4.44819
HSPA1B heat shock 70kDa protein 1B 4.07366
JUN jun proto-oncogene 4.01142
JMJD6 jumonji domain containing 6 3.9674
ABHD4 abhydrolase domain containing 4 3.85145
NOTCH1 notch 1 3.84416
CGRRF1 cell growth regulator with ring finger domain 1 3.79422
EGR1 early growth response 1 3.70866
PPARG peroxisome proliferator-activated receptor gamma 3.6098
GPER1 G protein-coupled estrogen receptor 1 3.57353
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.47609
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.46263
CNPY3 canopy FGF signaling regulator 3 3.40904
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 3.37665
EAPP E2F-associated phosphoprotein 3.19229
GADD45A growth arrest and DNA-damage-inducible, alpha 3.17843
MAP7 microtubule-associated protein 7 2.98201
CREB1 cAMP responsive element binding protein 1 2.8428
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.7163
NPDC1 neural proliferation, differentiation and control, 1 2.69686
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.63225
INPP1 inositol polyphosphate-1-phosphatase 2.61308
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.59529
PRKCH protein kinase C, eta 2.58346
H2BC12 H2B clustered histone 12 2.57984
TEX10 testis expressed 10 2.56503
RBM15B RNA binding motif protein 15B 2.53273
BZW2 basic leucine zipper and W2 domains 2 2.36272
FZD1 frizzled class receptor 1 2.35641
TREM1 triggering receptor expressed on myeloid cells 1 2.35516
ZFP36 ZFP36 ring finger protein 2.2743
TIAM1 T-cell lymphoma invasion and metastasis 1 2.23288
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.20825
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.19409
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.16656
AXIN1 axin 1 2.16433
MED17 mediator complex subunit 17 2.16003
BIRC2 baculoviral IAP repeat containing 2 2.13914
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.13251
MCOLN1 mucolipin 1 2.08183
LRRC59 leucine rich repeat containing 59 2.06273
GATA2 GATA binding protein 2 2.04464
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.04311
SMG8 SMG8 nonsense mediated mRNA decay factor 2.03098
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.02255
ARID4B AT rich interactive domain 4B (RBP1-like) 2.02188
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.01071

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.54425
PCCB propionyl CoA carboxylase, beta polypeptide -6.23266
GNAS GNAS complex locus -5.47621
MAPK13 mitogen-activated protein kinase 13 -4.94609
OXA1L oxidase (cytochrome c) assembly 1-like -4.80303
SLC35F2 solute carrier family 35, member F2 -4.60499
COG7 component of oligomeric golgi complex 7 -4.47523
TLCD3A TLC domain containing 3A -4.40907
SCAND1 SCAN domain containing 1 -4.04674
BLCAP bladder cancer associated protein -3.69298
RPIA ribose 5-phosphate isomerase A -3.38119
PCNA proliferating cell nuclear antigen -3.3607
CD58 CD58 molecule -3.3537
ARID5B AT rich interactive domain 5B (MRF1-like) -3.34316
IER3 immediate early response 3 -3.22802
HMG20B high mobility group 20B -3.1428
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.11569
TCEAL4 transcription elongation factor A (SII)-like 4 -2.69154
MTA1 metastasis associated 1 -2.58036
ACAA1 acetyl-CoA acyltransferase 1 -2.47645
MAT2A methionine adenosyltransferase II, alpha -2.44946
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.40107
GALE UDP-galactose-4-epimerase -2.38812
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.32285
ZW10 zw10 kinetochore protein -2.3159
TWF2 twinfilin actin binding protein 2 -2.29287
PSIP1 PC4 and SFRS1 interacting protein 1 -2.28156
WDR7 WD repeat domain 7 -2.27251
TCTN1 tectonic family member 1 -2.22888
TJP3 tight junction protein 3 -2.21149
DSG2 desmoglein 2 -2.20148
ACP6 acid phosphatase 6, lysophosphatidic -2.19882
NRIP1 nuclear receptor interacting protein 1 -2.12694
ADRM1 adhesion regulating molecule 1 -2.10898
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.1077
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.10534
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.10164
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.08642
ICAM3 intercellular adhesion molecule 3 -2.0845
PYGB phosphorylase, glycogen; brain -2.06523
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.06171
TM9SF2 transmembrane 9 superfamily member 2 -2.04862
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.02215
MRPS15 mitochondrial ribosomal protein S15 -2.00028