CRCGN014_HEPG2_3H:E07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

579 genes differentially expressed following the CRCGN014_HEPG2_3H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
E2F2 E2F transcription factor 2 10.0
MYLK myosin light chain kinase 9.30865
BACE2 beta-site APP-cleaving enzyme 2 8.9105
STIMATE STIM activating enhancer 8.5187
MAMLD1 mastermind-like domain containing 1 7.4302
TICAM1 toll-like receptor adaptor molecule 1 6.3838
ADGRE5 adhesion G protein-coupled receptor E5 6.3483
INSIG1 insulin induced gene 1 6.30785
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 5.73287
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.4922
SYNGR3 synaptogyrin 3 5.47235
GHR growth hormone receptor 5.24925
TNIP1 TNFAIP3 interacting protein 1 5.2173
MOK MOK protein kinase 5.18735
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 5.1859
TBC1D10C TBC1 domain family, member 10C 5.12725
ADRB2 adrenoceptor beta 2, surface 5.121
ANO1 anoctamin 1, calcium activated chloride channel 5.0
GSTZ1 glutathione S-transferase zeta 1 4.9418
TEX10 testis expressed 10 4.86915
HPRT1 hypoxanthine phosphoribosyltransferase 1 4.84765
BLMH bleomycin hydrolase 4.83855
EPHB2 EPH receptor B2 4.78662
CCDC85B coiled-coil domain containing 85B 4.7806
OXCT1 3-oxoacid CoA transferase 1 4.74855
IGFBP3 insulin-like growth factor binding protein 3 4.64122
NLRP4 NLR family, pyrin domain containing 4 4.63125
STXBP1 syntaxin binding protein 1 4.50695
CBR1 carbonyl reductase 1 4.45825
HOXA10 homeobox A10 4.42333
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.4063
PLSCR1 phospholipid scramblase 1 4.39135
PTPN6 protein tyrosine phosphatase, non-receptor type 6 4.29055
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 4.09825
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.02515
GFUS GDP-L-fucose synthase 3.9845
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.9594
JADE2 jade family PHD finger 2 3.88832
CELA3B chymotrypsin-like elastase family, member 3B 3.813
IAPP islet amyloid polypeptide 3.7963
CLPS colipase, pancreatic 3.7609
TRAK2 trafficking protein, kinesin binding 2 3.69177
CTRC chymotrypsin C (caldecrin) 3.68205
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 3.6685
CELA3A chymotrypsin-like elastase family, member 3A 3.66413
TSPO2 translocator protein 2 3.61645
TIAM1 T-cell lymphoma invasion and metastasis 1 3.39587
CTRB2 chymotrypsinogen B2 3.369
OXT oxytocin/neurophysin I prepropeptide 3.36565
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.36335
COQ8A coenzyme Q8A 3.354
PRSS58 protease, serine, 58 3.33455
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 3.31275
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.3108
SNAI1 snail family zinc finger 1 3.3006
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 3.2822
EVL Enah/Vasp-like 3.25685
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.2534
CELA2A chymotrypsin-like elastase family, member 2A 3.2383
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.2337
TRAM2 translocation associated membrane protein 2 3.23165
PARP1 poly (ADP-ribose) polymerase 1 3.2196
CPA2 carboxypeptidase A2 (pancreatic) 3.21945
PNLIP pancreatic lipase 3.20815
LOXL1 lysyl oxidase-like 1 3.19775
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 3.14435
SIRT3 sirtuin 3 3.1427
DPY19L4 dpy-19-like 4 (C. elegans) 3.13685
CPA1 carboxypeptidase A1 (pancreatic) 3.12355
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.1176
PRKCQ protein kinase C, theta 3.11258
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.1072
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.0852
PYCR3 pyrroline-5-carboxylate reductase 3 3.07985
SYNGAP1 synaptic Ras GTPase activating protein 1 3.07438
TNS3 tensin 3 3.067
SNAP25 synaptosomal-associated protein, 25kDa 3.05245
IFITM1 interferon induced transmembrane protein 1 3.03925
PLA1A phospholipase A1 member A 3.00395
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.9692
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.9631
GC group-specific component (vitamin D binding protein) 2.94375
IRF7 interferon regulatory factor 7 2.93015
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.91875
RSAD2 radical S-adenosyl methionine domain containing 2 2.9058
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.90557
LOC107985101 uncharacterized LOC107985101 2.90205
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.90185
SSX5 synovial sarcoma, X breakpoint 5 2.8628
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.86034
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 2.8426
GPR173 G protein-coupled receptor 173 2.832
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.8264
BMP8B bone morphogenetic protein 8b 2.80895
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.7972
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.7902
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.7875
EDN1 endothelin 1 2.7824
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.7758
DCAF11 DDB1 and CUL4 associated factor 11 2.77523
CALY calcyon neuron-specific vesicular protein 2.76825
PDE7B phosphodiesterase 7B 2.7458
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.74533
RASL11B RAS-like, family 11, member B 2.73955
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.73595
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.73565
SIGLEC15 sialic acid binding Ig-like lectin 15 2.73065
CEP57 centrosomal protein 57kDa 2.72962
TOLLIP toll interacting protein 2.71935
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.7098
PRR3 proline rich 3 2.70855
AANAT aralkylamine N-acetyltransferase 2.69345
FGF16 fibroblast growth factor 16 2.6862
MATN2 matrilin 2 2.6858
CCP110 centriolar coiled coil protein 110kDa 2.6788
CTRB1 chymotrypsinogen B1 2.6665
SCRIB scribbled planar cell polarity protein 2.6606
TOR3A torsin family 3, member A 2.65855
AFM afamin 2.6578
DNAAF8 dynein axonemal assembly factor 8 2.6456
DGKQ diacylglycerol kinase, theta 110kDa 2.64555
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 2.64375
OMP olfactory marker protein 2.64315
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.63665
GYG2 glycogenin 2 2.62867
PTCD1 pentatricopeptide repeat domain 1 2.62715
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 2.6264
HLA-DMA major histocompatibility complex, class II, DM alpha 2.62255
NKX2-8 NK2 homeobox 8 2.6201
ZNF142 zinc finger protein 142 2.5922
MROH7 maestro heat-like repeat family member 7 2.57535
MAT1A methionine adenosyltransferase I, alpha 2.56705
REPIN1 replication initiator 1 2.5636
ASB1 ankyrin repeat and SOCS box containing 1 2.55925
OLFML3 olfactomedin-like 3 2.5592
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.55265
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.551
DRP2 dystrophin related protein 2 2.53605
SOCS1 suppressor of cytokine signaling 1 2.53565
OVOL3 ovo-like zinc finger 3 2.53295
SLC38A4 solute carrier family 38, member 4 2.5307
PZP pregnancy-zone protein 2.5233
PAX9 paired box 9 2.5218
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.52115
DIXDC1 DIX domain containing 1 2.51725
GPR20 G protein-coupled receptor 20 2.51575
ZBTB48 zinc finger and BTB domain containing 48 2.51405
PCDHGA9 protocadherin gamma subfamily A, 9 2.50785
NCKIPSD NCK interacting protein with SH3 domain 2.50695
INS insulin 2.50245
GPR27 G protein-coupled receptor 27 2.50155
AMBP alpha-1-microglobulin/bikunin precursor 2.5003
NPY4R2 neuropeptide Y receptor Y4-2 2.4999
SGPP2 sphingosine-1-phosphate phosphatase 2 2.4982
CCDC88C coiled-coil domain containing 88C 2.49515
TAC4 tachykinin 4 (hemokinin) 2.4781
CAPN5 calpain 5 2.47715
PYGM phosphorylase, glycogen, muscle 2.4764
EGR4 early growth response 4 2.47252
HOXC5 homeobox C5 2.4704
GPR68 G protein-coupled receptor 68 2.46905
MYBPH myosin binding protein H 2.4597
SLC22A14 solute carrier family 22, member 14 2.45275
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.4522
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.43685
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.43488
CUZD1 CUB and zona pellucida-like domains 1 2.43425
UBE2O ubiquitin-conjugating enzyme E2O 2.4272
TPSG1 tryptase gamma 1 2.42695
PRDM8 PR domain containing 8 2.4234
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2.42298
ISG15 ISG15 ubiquitin-like modifier 2.42195
RWDD2B RWD domain containing 2B 2.4204
NEUROD4 neuronal differentiation 4 2.41735
ADSS2 adenylosuccinate synthase 2 2.41715
CNTFR ciliary neurotrophic factor receptor 2.41255
CHAD chondroadherin 2.4095
PLA2G2D phospholipase A2, group IID 2.40875
RTP4 receptor (chemosensory) transporter protein 4 2.40865
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 2.40775
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.4046
ZC4H2 zinc finger, C4H2 domain containing 2.4021
CRTAP cartilage associated protein 2.4001
CCNF cyclin F 2.3993
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.3965
PDGFA platelet-derived growth factor alpha polypeptide 2.39477
IFI27 interferon, alpha-inducible protein 27 2.38055
SLC66A3 solute carrier family 66 member 3 2.378
CRYBA2 crystallin, beta A2 2.3765
CAPN11 calpain 11 2.3502
WNT16 wingless-type MMTV integration site family, member 16 2.3486
PYDC1 PYD (pyrin domain) containing 1 2.34785
F13B coagulation factor XIII, B polypeptide 2.3478
HILPDA hypoxia inducible lipid droplet-associated 2.34765
CAPN6 calpain 6 2.34602
MATN1 matrilin 1, cartilage matrix protein 2.34282
FOXE3 forkhead box E3 2.34135
REG1B regenerating islet-derived 1 beta 2.34
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.3392
SQOR sulfide quinone oxidoreductase 2.33555
PUS3 pseudouridylate synthase 3 2.33465
CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough 2.33107
VTN vitronectin 2.3271
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2.32685
TGIF2 TGFB-induced factor homeobox 2 2.32685
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.3245
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.32307
CELA2B chymotrypsin-like elastase family, member 2B 2.32295
HOXD3 homeobox D3 2.3227
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.32205
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.32066
GJB1 gap junction protein, beta 1, 32kDa 2.3193
SST somatostatin 2.31875
CLDN10 claudin 10 2.3183
KAT6B K(lysine) acetyltransferase 6B 2.31796
AGXT alanine-glyoxylate aminotransferase 2.31215
PAX7 paired box 7 2.30345
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.30065
CDX4 caudal type homeobox 4 2.29895
SMG6 SMG6 nonsense mediated mRNA decay factor 2.29645
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.2936
ATG2B autophagy related 2B 2.29315
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.29145
CFHR5 complement factor H-related 5 2.28155
LAG3 lymphocyte-activation gene 3 2.28015
OXR1 oxidation resistance 1 2.2785
TEC tec protein tyrosine kinase 2.27685
IFNG interferon, gamma 2.27185
STX1A syntaxin 1A (brain) 2.2633
MTIF2 mitochondrial translational initiation factor 2 2.2602
MACO1 macoilin 1 2.25615
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.2559
SNCB synuclein, beta 2.25405
FOXH1 forkhead box H1 2.2534
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.2531
SLC7A4 solute carrier family 7, member 4 2.25245
WDR91 WD repeat domain 91 2.24865
CTRL chymotrypsin-like 2.24225
LGALS13 lectin, galactoside-binding, soluble, 13 2.23815
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.23505
RCOR1 REST corepressor 1 2.23445
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 2.2327
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.23215
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 2.23033
GSTM3 glutathione S-transferase mu 3 (brain) 2.22725
CCNP cyclin P 2.22265
DOT1L DOT1-like histone H3K79 methyltransferase 2.22075
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.22065
C8B complement component 8, beta polypeptide 2.2206
OASL 2'-5'-oligoadenylate synthetase-like 2.22045
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.21968
AKR1C4 aldo-keto reductase family 1, member C4 2.21965
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.2171
UTRN utrophin 2.21675
GUCA1B guanylate cyclase activator 1B (retina) 2.21605
PLS1 plastin 1 2.21595
PRSS22 protease, serine, 22 2.2158
PTBP2 polypyrimidine tract binding protein 2 2.2157
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.21217
PRND prion protein 2 (dublet) 2.21055
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.209
PIAS4 protein inhibitor of activated STAT, 4 2.20785
CREB3L1 cAMP responsive element binding protein 3-like 1 2.20368
IDO1 indoleamine 2,3-dioxygenase 1 2.2021
CRLF2 cytokine receptor-like factor 2 2.1965
ANGPT4 angiopoietin 4 2.19545
TMEM101 transmembrane protein 101 2.1936
RPP38 ribonuclease P/MRP 38kDa subunit 2.1924
SRY sex determining region Y 2.18865
SAP130 Sin3A-associated protein, 130kDa 2.1873
F9 coagulation factor IX 2.1848
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 2.1847
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.18275
MX1 MX dynamin-like GTPase 1 2.18085
SOX1 SRY (sex determining region Y)-box 1 2.1768
IFI6 interferon, alpha-inducible protein 6 2.17655
WT1 Wilms tumor 1 2.17357
GCGR glucagon receptor 2.16995
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.1699
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.16375
NKX3-2 NK3 homeobox 2 2.16285
PRDM12 PR domain containing 12 2.16145
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.16125
ZMYM2 zinc finger, MYM-type 2 2.1578
HLTF helicase-like transcription factor 2.1562
TNP1 transition protein 1 (during histone to protamine replacement) 2.1559
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.14558
HOXB1 homeobox B1 2.1442
PRAMEF12 PRAME family member 12 2.14365
FGF6 fibroblast growth factor 6 2.13975
TSG101 tumor susceptibility 101 2.1397
GFRA2 GDNF family receptor alpha 2 2.13803
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.13705
KRT24 keratin 24, type I 2.1318
OSBPL10 oxysterol binding protein-like 10 2.12755
AVPR1B arginine vasopressin receptor 1B 2.12705
FBXO31 F-box protein 31 2.1255
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 2.1254
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.1252
FZD5 frizzled class receptor 5 2.125
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.12165
ANGPTL3 angiopoietin-like 3 2.1209
UTF1 undifferentiated embryonic cell transcription factor 1 2.1208
CHIT1 chitinase 1 (chitotriosidase) 2.11815
CDX1 caudal type homeobox 1 2.11805
CEND1 cell cycle exit and neuronal differentiation 1 2.1153
MIDEAS mitotic deacetylase associated SANT domain protein 2.1124
SH2D3C SH2 domain containing 3C 2.1081
CHD8 chromodomain helicase DNA binding protein 8 2.10785
TRIP12 thyroid hormone receptor interactor 12 2.1033
ZBTB18 zinc finger and BTB domain containing 18 2.1025
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.10222
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.1011
MYH13 myosin, heavy chain 13, skeletal muscle 2.101
SHBG sex hormone-binding globulin 2.0991
PVALB parvalbumin 2.09465
APCS amyloid P component, serum 2.09245
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.09115
EPHA3 EPH receptor A3 2.09042
GCM1 glial cells missing homolog 1 (Drosophila) 2.087
DEFB126 defensin, beta 126 2.08665
SREK1 splicing regulatory glutamine/lysine-rich protein 1 2.0861
TEX13B testis expressed 13B 2.0859
NPC1L1 NPC1-like 1 2.0844
FGB fibrinogen beta chain 2.08282
AURKC aurora kinase C 2.0821
ABHD6 abhydrolase domain containing 6 2.0814
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.08095
ALX4 ALX homeobox 4 2.0798
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 2.07738
ZNF839 zinc finger protein 839 2.07678
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.07665
RIGI RNA sensor RIG-I 2.07465
PGM5 phosphoglucomutase 5 2.0736
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.07095
PPY pancreatic polypeptide 2.07065
FAM76A family with sequence similarity 76, member A 2.06925
PRODH2 proline dehydrogenase (oxidase) 2 2.0685
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.0679
DPF2 D4, zinc and double PHD fingers family 2 2.06715
OR10H2 olfactory receptor, family 10, subfamily H, member 2 2.0653
GALR2 galanin receptor 2 2.06445
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.06435
MYD88 myeloid differentiation primary response 88 2.0634
RAP1GAP RAP1 GTPase activating protein 2.0632
FZD8 frizzled class receptor 8 2.06205
MBL2 mannose-binding lectin (protein C) 2, soluble 2.0596
SHOX short stature homeobox 2.0596
TBCEL tubulin folding cofactor E-like 2.0583
PSEN1 presenilin 1 2.0571
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.05665
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.05485
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.05485
LPA lipoprotein, Lp(a) 2.0547
NTSR2 neurotensin receptor 2 2.05445
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.05262
TLX2 T-cell leukemia homeobox 2 2.0519
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.0505
SYTL2 synaptotagmin-like 2 2.04645
PNLIPRP1 pancreatic lipase-related protein 1 2.04353
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.04097
CDCP1 CUB domain containing protein 1 2.03545
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.0331
INHBB inhibin, beta B 2.03165
PRAMEF13 PRAME family member 13 2.0278
WNT4 wingless-type MMTV integration site family, member 4 2.0263
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.02415
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.02305
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.0223
PRKCG protein kinase C, gamma 2.0215
LOC102724594 splicing factor U2AF 35 kDa subunit 2.02085
CEL carboxyl ester lipase 2.02065
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough 2.01945
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.0193
IGF2 insulin-like growth factor 2 2.01645
SNTG2 syntrophin, gamma 2 2.0159
MITF microphthalmia-associated transcription factor 2.01575
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.01535
ZNF467 zinc finger protein 467 2.01475
HSPB3 heat shock 27kDa protein 3 2.0143
TTR transthyretin 2.01113
DUSP2 dual specificity phosphatase 2 2.01035
ZNF589 zinc finger protein 589 2.01005
IFI44L interferon-induced protein 44-like 2.0093
MDM4 MDM4, p53 regulator 2.00915
GJA3 gap junction protein, alpha 3, 46kDa 2.00885
NR1D1 nuclear receptor subfamily 1, group D, member 1 2.00575
HOXA11 homeobox A11 2.00278
SH2D1A SH2 domain containing 1A 2.00175
SAXO6 stabilizer of axonemal microtubules 6 2.001
SHH sonic hedgehog 2.00045
BHMT2 betaine--homocysteine S-methyltransferase 2 2.00035

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -10.0
ITFG1 integrin alpha FG-GAP repeat containing 1 -7.5037
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.07815
ZDHHC6 zinc finger, DHHC-type containing 6 -6.7932
NT5DC2 5'-nucleotidase domain containing 2 -5.7861
TLR4 toll-like receptor 4 -5.48065
CCNB2 cyclin B2 -5.37445
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.19
GTPBP8 GTP-binding protein 8 (putative) -5.17105
PCNA proliferating cell nuclear antigen -5.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.8551
COG4 component of oligomeric golgi complex 4 -4.85295
ZNF586 zinc finger protein 586 -4.7192
THAP11 THAP domain containing 11 -4.62495
ADI1 acireductone dioxygenase 1 -4.5394
PPP1R26 protein phosphatase 1, regulatory subunit 26 -4.47685
FASTKD5 FAST kinase domains 5 -4.4753
NGRN neugrin, neurite outgrowth associated -4.43895
CAB39 calcium binding protein 39 -4.31635
MAPK13 mitogen-activated protein kinase 13 -4.28433
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.15415
RFC2 replication factor C (activator 1) 2, 40kDa -4.0281
RGS2 regulator of G-protein signaling 2 -3.7178
CD58 CD58 molecule -3.62183
CRTC3 CREB regulated transcription coactivator 3 -3.57075
AKAP8 A kinase (PRKA) anchor protein 8 -3.47738
CSK c-src tyrosine kinase -3.44815
PSIP1 PC4 and SFRS1 interacting protein 1 -3.32512
WDR7 WD repeat domain 7 -3.28125
TCTN1 tectonic family member 1 -3.2404
STXBP2 syntaxin binding protein 2 -3.09375
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.07787
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -3.06715
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -3.0335
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -3.0311
UBE2A ubiquitin-conjugating enzyme E2A -3.02762
BMP2 bone morphogenetic protein 2 -3.02395
IFRD2 interferon-related developmental regulator 2 -3.0236
CLTB clathrin, light chain B -3.01318
PWP1 PWP1 homolog (S. cerevisiae) -3.00027
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.93745
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.9365
KIF23 kinesin family member 23 -2.92225
ARID5B AT rich interactive domain 5B (MRF1-like) -2.92055
BZW2 basic leucine zipper and W2 domains 2 -2.89875
SETD6 SET domain containing 6 -2.88415
NIP7 NIP7, nucleolar pre-rRNA processing protein -2.8815
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.86485
CENPT centromere protein T -2.7987
PAEP progestagen-associated endometrial protein -2.7931
CISD1 CDGSH iron sulfur domain 1 -2.7919
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.78645
RBFA ribosome binding factor A (putative) -2.7861
QTMAN queuosine-tRNA mannosyltransferase -2.76725
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.75615
ANKRD10 ankyrin repeat domain 10 -2.74335
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.74325
UBAC1 UBA domain containing 1 -2.71755
TACC2 transforming, acidic coiled-coil containing protein 2 -2.71168
DHRS3 dehydrogenase/reductase (SDR family) member 3 -2.69275
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.6838
MAP2K5 mitogen-activated protein kinase kinase 5 -2.67885
PTPRK protein tyrosine phosphatase, receptor type, K -2.6751
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.6451
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.6408
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.6403
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa -2.62033
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.6192
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.61415
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.58305
TRMT61B tRNA methyltransferase 61B -2.57585
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.56315
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -2.532
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.52815
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -2.51662
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.4971
SCAND1 SCAN domain containing 1 -2.4855
TUFM Tu translation elongation factor, mitochondrial -2.48055
ZWILCH zwilch kinetochore protein -2.47985
COPS7A COP9 signalosome subunit 7A -2.47095
IPO13 importin 13 -2.464
GGCT gamma-glutamylcyclotransferase -2.4639
TUBB4B tubulin, beta 4B class IVb -2.46338
PDF peptide deformylase (mitochondrial) -2.45805
COQ4 coenzyme Q4 -2.44075
COQ9 coenzyme Q9 -2.4321
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.42933
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.41515
MTA1 metastasis associated 1 -2.40427
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -2.387
DXO decapping exoribonuclease -2.38203
UPK3B uroplakin 3B -2.3818
NVL nuclear VCP-like -2.3794
MLF2 myeloid leukemia factor 2 -2.37665
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.36475
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.36295
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -2.36225
MYO9A myosin IXA -2.35545
CRBN cereblon -2.35355
ZBTB22 zinc finger and BTB domain containing 22 -2.3518
HS1BP3 HCLS1 binding protein 3 -2.3507
OIP5 Opa interacting protein 5 -2.34865
CZIB CXXC motif containing zinc binding protein -2.3456
PCLAF PCNA clamp associated factor -2.34382
ORC6 origin recognition complex, subunit 6 -2.33635
YARS1 tyrosyl-tRNA synthetase 1 -2.33115
TRAPPC12 trafficking protein particle complex 12 -2.3302
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.32255
GOLPH3 golgi phosphoprotein 3 (coat-protein) -2.30875
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.302
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.2998
TMEM222 transmembrane protein 222 -2.29855
DCK deoxycytidine kinase -2.2951
MPV17 MpV17 mitochondrial inner membrane protein -2.2944
SEC16A SEC16 homolog A (S. cerevisiae) -2.29225
CUEDC2 CUE domain containing 2 -2.29115
MALT1 MALT1 paracaspase -2.29063
TSPAN1 tetraspanin 1 -2.2884
EFL1 elongation factor like GTPase 1 -2.2746
NUSAP1 nucleolar and spindle associated protein 1 -2.27008
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.26852
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.26612
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.25945
PMPCA peptidase (mitochondrial processing) alpha -2.25785
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.25668
TM9SF2 transmembrane 9 superfamily member 2 -2.2562
MSRA methionine sulfoxide reductase A -2.2449
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.2414
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.23855
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.2384
SMG8 SMG8 nonsense mediated mRNA decay factor -2.2365
HYOU1 hypoxia up-regulated 1 -2.2303
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.2274
TSC22D4 TSC22 domain family, member 4 -2.20535
RAD51AP1 RAD51 associated protein 1 -2.19365
BPHL biphenyl hydrolase-like (serine hydrolase) -2.1813
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.1803
HOMER3 homer scaffolding protein 3 -2.17067
PDCD6 programmed cell death 6 -2.1566
HPS6 Hermansky-Pudlak syndrome 6 -2.15645
HEATR3 HEAT repeat containing 3 -2.15425
ACY1 aminoacylase 1 -2.1517
FAM216A family with sequence similarity 216, member A -2.15125
GIPC1 GIPC PDZ domain containing family, member 1 -2.149
TRIP13 thyroid hormone receptor interactor 13 -2.14885
ARRB2 arrestin, beta 2 -2.1466
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.13875
DUSP14 dual specificity phosphatase 14 -2.1296
EPCIP exosomal polycystin 1 interacting protein -2.1277
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.1155
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.1068
NELFB negative elongation factor complex member B -2.10055
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.09445
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -2.09355
PYGL phosphorylase, glycogen, liver -2.09185
YBX3 Y box binding protein 3 -2.09172
APRT adenine phosphoribosyltransferase -2.08663
LGALSL lectin, galactoside-binding-like -2.08605
DCLRE1B DNA cross-link repair 1B -2.0816
MAP2K1 mitogen-activated protein kinase kinase 1 -2.07865
FEM1B fem-1 homolog b (C. elegans) -2.07045
LTBP1 latent transforming growth factor beta binding protein 1 -2.06245
IGLL1 immunoglobulin lambda-like polypeptide 1 -2.0577
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.057
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.0497
LRRC1 leucine rich repeat containing 1 -2.04848
DYNLT1 dynein, light chain, Tctex-type 1 -2.04415
POMZP3 POM121 and ZP3 fusion -2.03912
FURIN furin (paired basic amino acid cleaving enzyme) -2.039
ARID5A AT rich interactive domain 5A (MRF1-like) -2.03705
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.03505
ADORA3 adenosine A3 receptor -2.0268
PUM2 pumilio RNA-binding family member 2 -2.02603
CHPF chondroitin polymerizing factor -2.02515
BRD3 bromodomain containing 3 -2.02507
TSKU tsukushi, small leucine rich proteoglycan -2.02225
UNG uracil-DNA glycosylase -2.02
KLHL9 kelch-like family member 9 -2.01853
HOXC11 homeobox C11 -2.0182
PROS1 protein S (alpha) -2.0158
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.0148
RUFY1 RUN and FYVE domain containing 1 -2.01255
FTO fat mass and obesity associated -2.01045
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.00845
ZNF219 zinc finger protein 219 -2.00355
MFAP2 microfibrillar-associated protein 2 -2.0024