CRCGN014_HEPG2_3H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN014_HEPG2_3H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.49397
PEX11A peroxisomal biogenesis factor 11 alpha 6.31821
PPARG peroxisome proliferator-activated receptor gamma 5.48125
MYLK myosin light chain kinase 5.09247
SQOR sulfide quinone oxidoreductase 4.34164
MAMLD1 mastermind-like domain containing 1 4.18822
BACE2 beta-site APP-cleaving enzyme 2 3.96411
CBR3 carbonyl reductase 3 3.8149
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.69729
E2F2 E2F transcription factor 2 3.61501
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.49449
ADGRE5 adhesion G protein-coupled receptor E5 3.48586
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.43487
GPER1 G protein-coupled estrogen receptor 1 3.25897
TIAM1 T-cell lymphoma invasion and metastasis 1 3.16379
MAP7 microtubule-associated protein 7 3.15987
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.12747
TAC4 tachykinin 4 (hemokinin) 3.12012
JADE2 jade family PHD finger 2 3.05161
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.01092
ALDOC aldolase C, fructose-bisphosphate 2.99762
NOTCH1 notch 1 2.96503
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.95116
HOXA10 homeobox A10 2.81319
TREM1 triggering receptor expressed on myeloid cells 1 2.75427
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.69191
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.68623
BLMH bleomycin hydrolase 2.64412
C2CD2 C2 calcium-dependent domain containing 2 2.62342
KIF20A kinesin family member 20A 2.60987
EDN2 endothelin 2 2.54247
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.49996
UFM1 ubiquitin-fold modifier 1 2.48411
CHN1 chimerin 1 2.4495
CEMIP2 cell migration inducing hyaluronidase 2 2.43583
ERBB3 erb-b2 receptor tyrosine kinase 3 2.4151
CCL2 chemokine (C-C motif) ligand 2 2.41134
KIF5C kinesin family member 5C 2.37278
PCDHGA10 protocadherin gamma subfamily A, 10 2.3605
LY75-CD302 LY75-CD302 readthrough 2.30654
PTK2 protein tyrosine kinase 2 2.29756
STIMATE STIM activating enhancer 2.28928
EPHA3 EPH receptor A3 2.25951
SSBP2 single-stranded DNA binding protein 2 2.24051
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.21865
GFRA1 GDNF family receptor alpha 1 2.21069
ZNF660-ZNF197 ZNF660-ZNF197 readthrough 2.21019
ANKH ANKH inorganic pyrophosphate transport regulator 2.20652
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.17798
STX1A syntaxin 1A (brain) 2.17472
FCHO1 FCH domain only 1 2.09916
KRT18 keratin 18, type I 2.09305
IFT81 intraflagellar transport 81 2.04523
EGF epidermal growth factor 2.01768
TCTN1 tectonic family member 1 2.00952

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.79216
CCNB2 cyclin B2 -6.15199
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -6.02843
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.18502
LOC124907782 dual specificity protein phosphatase 22 -5.12397
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -4.67974
SPAG4 sperm associated antigen 4 -4.0118
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.98271
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.33003
LDHD lactate dehydrogenase D -3.19343
PCNA proliferating cell nuclear antigen -3.18595
FASTKD5 FAST kinase domains 5 -2.78207
TLR4 toll-like receptor 4 -2.66451
HMG20B high mobility group 20B -2.59171
WDR7 WD repeat domain 7 -2.49554
ARID5B AT rich interactive domain 5B (MRF1-like) -2.44506
RNF167 ring finger protein 167 -2.41043
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.30104
AUP1 ancient ubiquitous protein 1 -2.2088
CAMLG calcium modulating ligand -2.18417
TLCD3A TLC domain containing 3A -2.17238
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.15677
NUSAP1 nucleolar and spindle associated protein 1 -2.13221
RAB3A RAB3A, member RAS oncogene family -2.10586
ZMIZ1 zinc finger, MIZ-type containing 1 -2.08191
NCK1 NCK adaptor protein 1 -2.07179
PGAP2 post-GPI attachment to proteins 2 -2.06938
TOR1A torsin family 1, member A (torsin A) -2.03667
CLTB clathrin, light chain B -2.03571
ZNF668 zinc finger protein 668 -2.00465