CRCGN014_HEPG2_3H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dehydroisoandosterone 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN014_HEPG2_3H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 7.86781
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 6.81593
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.45855
SHB Src homology 2 domain containing adaptor protein B 5.09087
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.17489
ANO1 anoctamin 1, calcium activated chloride channel 4.07507
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.17033
KIFBP kinesin family binding protein 3.05635
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.05124
CXCL2 chemokine (C-X-C motif) ligand 2 3.00105
TRIB3 tribbles pseudokinase 3 2.98831
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.91149
EGR1 early growth response 1 2.88671
CCP110 centriolar coiled coil protein 110kDa 2.88598
CARMIL1 capping protein regulator and myosin 1 linker 1 2.8791
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.85234
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.85062
LPAR2 lysophosphatidic acid receptor 2 2.80368
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.76525
SCRN1 secernin 1 2.51811
MEF2C myocyte enhancer factor 2C 2.4258
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.42531
PIH1D1 PIH1 domain containing 1 2.298
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.1964
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.18573
LARP6 La ribonucleoprotein domain family, member 6 2.17815
IER3 immediate early response 3 2.10375
RAB21 RAB21, member RAS oncogene family 2.10338
CCDC85B coiled-coil domain containing 85B 2.10026
ADORA2B adenosine A2b receptor 2.08884
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.08552
PADI2 peptidyl arginine deiminase, type II 2.05726
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.04878
EVI2A ecotropic viral integration site 2A 2.00812
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.00426

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.25562
FASTKD5 FAST kinase domains 5 -7.7835
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.71507
UBE3C ubiquitin protein ligase E3C -4.21272
ANKRD10 ankyrin repeat domain 10 -4.15383
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.53135
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.45039
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.33387
LDHD lactate dehydrogenase D -3.07552
PSRC1 proline/serine-rich coiled-coil 1 -3.07489
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.04193
HSPB1 heat shock 27kDa protein 1 -3.02969
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.94253
PRPF4 pre-mRNA processing factor 4 -2.88484
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.82139
CDC25B cell division cycle 25B -2.78283
THAP11 THAP domain containing 11 -2.74713
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.71736
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.6956
GRWD1 glutamate-rich WD repeat containing 1 -2.66655
ZMIZ1 zinc finger, MIZ-type containing 1 -2.56973
BLCAP bladder cancer associated protein -2.50701
TLR4 toll-like receptor 4 -2.46427
TXLNA taxilin alpha -2.46405
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.44663
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.3714
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.36072
KEAP1 kelch-like ECH-associated protein 1 -2.28534
SNX11 sorting nexin 11 -2.22944
LRP10 low density lipoprotein receptor-related protein 10 -2.22621
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.2239
CCDC92 coiled-coil domain containing 92 -2.22275
THAP3 THAP domain containing, apoptosis associated protein 3 -2.21993
TCTN1 tectonic family member 1 -2.21012
ZNF587B zinc finger protein 587B -2.20305
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.19751
MTO1 mitochondrial tRNA translation optimization 1 -2.13035
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.12014
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.09679
CCNF cyclin F -2.0954
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.09423
SAFB2 scaffold attachment factor B2 -2.08328
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.07276
FAAP100 FA core complex associated protein 100 -2.0483
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.01008
SPACA9 sperm acrosome associated 9 -2.00898
OXA1L oxidase (cytochrome c) assembly 1-like -2.00649
EDC4 enhancer of mRNA decapping 4 -2.00485