CRCGN014_HEPG2_3H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 38.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN014_HEPG2_3H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 6.15833
CHN1 chimerin 1 4.75809
MAP7 microtubule-associated protein 7 4.245
CHMP6 charged multivesicular body protein 6 4.00093
MYLK myosin light chain kinase 3.3713
UBQLN2 ubiquilin 2 3.07529
CBR3 carbonyl reductase 3 2.91287
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.88873
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.64076
CYCS cytochrome c, somatic 2.56486
SSBP2 single-stranded DNA binding protein 2 2.55205
ZBTB18 zinc finger and BTB domain containing 18 2.47465
WDTC1 WD and tetratricopeptide repeats 1 2.25801
ANO1 anoctamin 1, calcium activated chloride channel 2.25391
SYNGAP1 synaptic Ras GTPase activating protein 1 2.2382

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.86916
MAPK13 mitogen-activated protein kinase 13 -5.09806
KDM3A lysine (K)-specific demethylase 3A -4.82733
OXA1L oxidase (cytochrome c) assembly 1-like -4.00451
NT5DC2 5'-nucleotidase domain containing 2 -3.87279
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.66824
CCNB1 cyclin B1 -3.63656
FASTKD5 FAST kinase domains 5 -3.6104
CCNB2 cyclin B2 -3.41263
PCNA proliferating cell nuclear antigen -3.40707
UGDH UDP-glucose 6-dehydrogenase -3.39839
SNX11 sorting nexin 11 -2.52469
CLEC10A C-type lectin domain family 10, member A -2.52402
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.3555
FGFR4 fibroblast growth factor receptor 4 -2.19896
ZBTB48 zinc finger and BTB domain containing 48 -2.13293
GADD45G growth arrest and DNA-damage-inducible, gamma -2.11287