CRCGN014_HEPG2_3H:E13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethylstilbestrol 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

170 genes differentially expressed following the CRCGN014_HEPG2_3H:E13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BAG3 BCL2-associated athanogene 3 10.0
HSPA1A heat shock 70kDa protein 1A 10.0
DDIT4 DNA-damage-inducible transcript 4 7.68377
EGR1 early growth response 1 7.38926
H2BC12 H2B clustered histone 12 7.27305
HSPB1 heat shock 27kDa protein 1 6.79269
FOS FBJ murine osteosarcoma viral oncogene homolog 6.47064
JUN jun proto-oncogene 5.91687
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 5.52456
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 5.44648
PNKP polynucleotide kinase 3'-phosphatase 4.79768
HSPA1B heat shock 70kDa protein 1B 4.33903
KIFBP kinesin family binding protein 4.25968
RRAGA Ras-related GTP binding A 4.2553
RPL39L ribosomal protein L39-like 4.16764
RFC2 replication factor C (activator 1) 2, 40kDa 4.07459
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.64623
ZFP36 ZFP36 ring finger protein 3.61596
PPARG peroxisome proliferator-activated receptor gamma 3.50361
FOSL1 FOS-like antigen 1 3.48547
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.413
IER2 immediate early response 2 3.3449
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.29385
TRIB1 tribbles pseudokinase 1 3.26062
GADD45B growth arrest and DNA-damage-inducible, beta 3.22791
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.20338
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.18944
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.18626
PLS1 plastin 1 3.16525
E2F2 E2F transcription factor 2 3.15709
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.06917
H2BC4 H2B clustered histone 4 3.0286
MINDY1 MINDY lysine 48 deubiquitinase 1 3.00397
CYCS cytochrome c, somatic 2.98877
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.9881
H2BC9 H2B clustered histone 9 2.86194
CGRRF1 cell growth regulator with ring finger domain 1 2.85383
INPP1 inositol polyphosphate-1-phosphatase 2.83452
KDM5A lysine (K)-specific demethylase 5A 2.81001
ARID4B AT rich interactive domain 4B (RBP1-like) 2.80072
GSTZ1 glutathione S-transferase zeta 1 2.79427
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.79303
AMDHD2 amidohydrolase domain containing 2 2.77849
INTS3 integrator complex subunit 3 2.71062
ICAM1 intercellular adhesion molecule 1 2.69223
ATF3 activating transcription factor 3 2.67897
STX1A syntaxin 1A (brain) 2.65757
LOC128125814 uncharacterized LOC128125814 2.62174
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.62116
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.56478
ZNF331 zinc finger protein 331 2.563
CASC3 cancer susceptibility candidate 3 2.55543
STXBP2 syntaxin binding protein 2 2.53706
ALAS1 5'-aminolevulinate synthase 1 2.52043
H2BC3 H2B clustered histone 3 2.49099
CDKN2AIP CDKN2A interacting protein 2.48585
IL1A interleukin 1, alpha 2.45459
H1-2 H1.2 linker histone, cluster member 2.45452
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.3997
TUFT1 tuftelin 1 2.3797
FRS2 fibroblast growth factor receptor substrate 2 2.37224
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.37118
PRAF2 PRA1 domain family, member 2 2.36379
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.35949
ABHD4 abhydrolase domain containing 4 2.35189
ZMYM2 zinc finger, MYM-type 2 2.30068
MICALL1 MICAL-like 1 2.29514
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.2832
SYNE2 spectrin repeat containing, nuclear envelope 2 2.27714
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.27695
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.27621
KMT5B lysine methyltransferase 5B 2.27219
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.2344
H2AC19 H2A clustered histone 19 2.22842
CDPF1 cysteine-rich, DPF motif domain containing 1 2.22707
H2BC5 H2B clustered histone 5 2.18379
CHN1 chimerin 1 2.16412
FIP1L1 factor interacting with PAPOLA and CPSF1 2.16353
BHLHE40 basic helix-loop-helix family, member e40 2.14414
ZCCHC10 zinc finger, CCHC domain containing 10 2.14208
CCDC85B coiled-coil domain containing 85B 2.13738
SLFN12 schlafen family member 12 2.10086
H2AC6 H2A clustered histone 6 2.1005
KLHL9 kelch-like family member 9 2.09874
ZNF227 zinc finger protein 227 2.09627
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.08766
PAX9 paired box 9 2.07653
RSF1 remodeling and spacing factor 1 2.07197
CREB1 cAMP responsive element binding protein 1 2.07046
RHOB ras homolog family member B 2.06012
IER5 immediate early response 5 2.05604
H2AC7 H2A clustered histone 7 2.05392
HCFC2 host cell factor C2 2.03648
ZBTB38 zinc finger and BTB domain containing 38 2.02717
BTG2 BTG family, member 2 2.01673
FNDC3B fibronectin type III domain containing 3B 2.00419

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.86884
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.52451
GET1 guided entry of tail-anchored proteins factor 1 -5.39507
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -5.14396
NT5DC2 5'-nucleotidase domain containing 2 -4.85105
THAP11 THAP domain containing 11 -4.67906
ETFB electron-transfer-flavoprotein, beta polypeptide -4.53237
RPN1 ribophorin I -3.77648
LAP3 leucine aminopeptidase 3 -3.76503
RUVBL1 RuvB-like AAA ATPase 1 -3.73578
BLCAP bladder cancer associated protein -3.72894
CRYZ crystallin, zeta (quinone reductase) -3.52954
SLC35F2 solute carrier family 35, member F2 -3.51751
PCNA proliferating cell nuclear antigen -3.45435
UBE3C ubiquitin protein ligase E3C -3.34725
LDHD lactate dehydrogenase D -3.31614
DSG2 desmoglein 2 -3.31436
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.31202
EIF5 eukaryotic translation initiation factor 5 -3.15068
MRPS2 mitochondrial ribosomal protein S2 -2.92299
GNAS GNAS complex locus -2.9223
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.90082
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.90027
TXLNA taxilin alpha -2.80005
APEH acylaminoacyl-peptide hydrolase -2.75662
TFDP1 transcription factor Dp-1 -2.7294
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -2.72603
USP22 ubiquitin specific peptidase 22 -2.69192
ELAC2 elaC ribonuclease Z 2 -2.66208
ADI1 acireductone dioxygenase 1 -2.66166
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.65457
PARP1 poly (ADP-ribose) polymerase 1 -2.64811
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.64517
TCTN1 tectonic family member 1 -2.6451
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.58537
PRCP prolylcarboxypeptidase (angiotensinase C) -2.54598
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.53006
AKAP8 A kinase (PRKA) anchor protein 8 -2.50686
SKIC2 SKI2 subunit of superkiller complex -2.49519
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.47227
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.46183
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.44698
MAT2A methionine adenosyltransferase II, alpha -2.41613
SCAND1 SCAN domain containing 1 -2.38188
NGRN neugrin, neurite outgrowth associated -2.36216
POLK polymerase (DNA directed) kappa -2.35337
MARCKSL1 MARCKS-like 1 -2.33609
CDC20 cell division cycle 20 -2.31823
NRIP1 nuclear receptor interacting protein 1 -2.31778
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.29044
RBBP4 retinoblastoma binding protein 4 -2.28316
NUP85 nucleoporin 85kDa -2.26002
UGDH UDP-glucose 6-dehydrogenase -2.24308
BRCA1 breast cancer 1, early onset -2.23308
ANXA7 annexin A7 -2.20265
SNX11 sorting nexin 11 -2.17423
MRPL3 mitochondrial ribosomal protein L3 -2.16954
LOC124907782 dual specificity protein phosphatase 22 -2.16695
RPIA ribose 5-phosphate isomerase A -2.16015
TM9SF2 transmembrane 9 superfamily member 2 -2.13615
SLIRP SRA stem-loop interacting RNA binding protein -2.13506
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.13267
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.11194
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.08698
C2CD5 C2 calcium-dependent domain containing 5 -2.07931
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0652
ACAA1 acetyl-CoA acyltransferase 1 -2.06327
PDF peptide deformylase (mitochondrial) -2.06276
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.03672
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.02434
GYG2 glycogenin 2 -2.01888
IFRD2 interferon-related developmental regulator 2 -2.0161
MOK MOK protein kinase -2.00244
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.00228