CRCGN014_HEPG2_3H:E14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosodiethylamine 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

201 genes differentially expressed following the CRCGN014_HEPG2_3H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.547
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.44167
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.37138
LCN2 lipocalin 2 4.90716
STIMATE STIM activating enhancer 4.8524
CXCL2 chemokine (C-X-C motif) ligand 2 4.72861
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.71315
E2F2 E2F transcription factor 2 4.61852
ATP11B ATPase, class VI, type 11B 4.53109
NT5DC2 5'-nucleotidase domain containing 2 4.5201
CSK c-src tyrosine kinase 4.47739
CHN1 chimerin 1 4.3757
BZW2 basic leucine zipper and W2 domains 2 4.21484
NOSIP nitric oxide synthase interacting protein 4.19347
MUC1 mucin 1, cell surface associated 4.14098
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.08925
TIAM1 T-cell lymphoma invasion and metastasis 1 4.05099
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.01438
GSTZ1 glutathione S-transferase zeta 1 3.93138
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.68018
BAD BCL2-associated agonist of cell death 3.67647
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.53893
CYCS cytochrome c, somatic 3.2828
SFTPB surfactant protein B 3.19739
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.15649
RAX retina and anterior neural fold homeobox 3.12435
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.04773
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.0434
STK10 serine/threonine kinase 10 2.96456
KLHL9 kelch-like family member 9 2.93163
NKX2-5 NK2 homeobox 5 2.80445
JADE2 jade family PHD finger 2 2.79293
ZNF274 zinc finger protein 274 2.75429
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.7387
DGKQ diacylglycerol kinase, theta 110kDa 2.73854
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.70981
GJA3 gap junction protein, alpha 3, 46kDa 2.67062
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.67048
CCNF cyclin F 2.62964
SLC12A9 solute carrier family 12, member 9 2.62536
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.61982
TLK2 tousled-like kinase 2 2.57753
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.52887
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.51549
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 2.45051
PRDM8 PR domain containing 8 2.43613
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.43098
HSF4 heat shock transcription factor 4 2.42285
GHR growth hormone receptor 2.42207
CNTFR ciliary neurotrophic factor receptor 2.41735
MSRA methionine sulfoxide reductase A 2.4102
GP9 glycoprotein IX (platelet) 2.40258
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.39731
FAT2 FAT atypical cadherin 2 2.39281
CHEK2 checkpoint kinase 2 2.38907
CHERP calcium homeostasis endoplasmic reticulum protein 2.38513
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.3774
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.36807
MEST mesoderm specific transcript 2.33931
CATSPERB catsper channel auxiliary subunit beta 2.3335
FXYD1 FXYD domain containing ion transport regulator 1 2.33269
EPHX2 epoxide hydrolase 2, cytoplasmic 2.32456
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.31815
CTF1 cardiotrophin 1 2.30962
COG2 component of oligomeric golgi complex 2 2.30717
BAG1 BCL2-associated athanogene 2.29941
TBX2 T-box 2 2.29035
TGM5 transglutaminase 5 2.28763
TMEM109 transmembrane protein 109 2.2873
PHKB phosphorylase kinase, beta 2.28285
CDK8 cyclin-dependent kinase 8 2.27889
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.27624
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.27396
CCNT1 cyclin T1 2.25669
MAEA macrophage erythroblast attacher 2.24553
LSR lipolysis stimulated lipoprotein receptor 2.24333
ERMP1 endoplasmic reticulum metallopeptidase 1 2.24076
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.23928
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.23571
WNT4 wingless-type MMTV integration site family, member 4 2.22678
INSM1 insulinoma-associated 1 2.22438
TMEM223 transmembrane protein 223 2.22038
EGF epidermal growth factor 2.21794
HOXB1 homeobox B1 2.21688
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.21468
CD5 CD5 molecule 2.20659
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.19436
KPTN kaptin (actin binding protein) 2.18517
BIN2 bridging integrator 2 2.18318
MAPK9 mitogen-activated protein kinase 9 2.17664
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.17225
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.16479
NEUROG1 neurogenin 1 2.16153
FOCAD focadhesin 2.13365
HAPLN2 hyaluronan and proteoglycan link protein 2 2.12865
PRLH prolactin releasing hormone 2.12588
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.11561
CNGA1 cyclic nucleotide gated channel alpha 1 2.11408
GPS1 G protein pathway suppressor 1 2.113
RORC RAR-related orphan receptor C 2.10478
LRRC59 leucine rich repeat containing 59 2.09958
SNRPA small nuclear ribonucleoprotein polypeptide A 2.09802
TGFBI transforming growth factor, beta-induced, 68kDa 2.09706
CLASRP CLK4-associating serine/arginine rich protein 2.09151
PLCH2 phospholipase C, eta 2 2.08499
INTS15 integrator complex subunit 15 2.08183
EXTL1 exostosin-like glycosyltransferase 1 2.08091
COQ8A coenzyme Q8A 2.0794
DHPS deoxyhypusine synthase 2.07936
SHB Src homology 2 domain containing adaptor protein B 2.07137
COL7A1 collagen, type VII, alpha 1 2.06468
MAPK4 mitogen-activated protein kinase 4 2.06137
HMG20B high mobility group 20B 2.05783
IL2RB interleukin 2 receptor, beta 2.05385
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.05271
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.05113
FOXN1 forkhead box N1 2.04755
DCAF11 DDB1 and CUL4 associated factor 11 2.0472
AMDHD2 amidohydrolase domain containing 2 2.04431
PRX periaxin 2.04417
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.04292
ILK integrin-linked kinase 2.04092
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.03554
DUSP8 dual specificity phosphatase 8 2.03483
MRPS2 mitochondrial ribosomal protein S2 2.03166
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.03026
ITGB8 integrin, beta 8 2.02623
NFX1 nuclear transcription factor, X-box binding 1 2.0233
SOSTDC1 sclerostin domain containing 1 2.02071
PHEX phosphate regulating endopeptidase homolog, X-linked 2.01611
FLT3 fms-related tyrosine kinase 3 2.01594
ING4 inhibitor of growth family, member 4 2.01307
ROGDI rogdi homolog (Drosophila) 2.00936
COL4A1 collagen, type IV, alpha 1 2.00255
OVOL3 ovo-like zinc finger 3 2.00246

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.99288
MAPK13 mitogen-activated protein kinase 13 -7.98586
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.01051
CAB39 calcium binding protein 39 -5.23112
ETFB electron-transfer-flavoprotein, beta polypeptide -5.04851
ZNF586 zinc finger protein 586 -4.90496
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.71433
THAP11 THAP domain containing 11 -4.59295
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.30818
WASHC4 WASH complex subunit 4 -3.99872
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.82945
TLR4 toll-like receptor 4 -3.65113
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -3.56661
CCNH cyclin H -3.45794
GNAS GNAS complex locus -3.34922
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.30106
GLOD4 glyoxalase domain containing 4 -3.28782
SCAND1 SCAN domain containing 1 -3.26238
PRCP prolylcarboxypeptidase (angiotensinase C) -3.19758
APOE apolipoprotein E -3.19156
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.12772
TXNDC9 thioredoxin domain containing 9 -3.10589
VAT1 vesicle amine transport 1 -3.10357
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.01587
CHMP1A charged multivesicular body protein 1A -2.99243
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.90075
PNPLA3 patatin-like phospholipase domain containing 3 -2.79649
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.79306
MSMO1 methylsterol monooxygenase 1 -2.66702
HLA-DMA major histocompatibility complex, class II, DM alpha -2.62468
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.59551
NUP93 nucleoporin 93kDa -2.58556
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.55812
HAMP hepcidin antimicrobial peptide -2.52669
DDIT4 DNA-damage-inducible transcript 4 -2.50999
IST1 increased sodium tolerance 1 homolog (yeast) -2.46207
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.41525
CRYZ crystallin, zeta (quinone reductase) -2.40788
ACAA1 acetyl-CoA acyltransferase 1 -2.40727
APOB apolipoprotein B -2.3777
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.36893
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.35799
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.33552
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.32412
CHEK1 checkpoint kinase 1 -2.25572
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.24774
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.22302
HMGA2 high mobility group AT-hook 2 -2.20733
DDB2 damage-specific DNA binding protein 2, 48kDa -2.19885
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.18184
COPG1 coatomer protein complex, subunit gamma 1 -2.18126
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.15821
APRT adenine phosphoribosyltransferase -2.15303
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.15016
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.1475
CES2 carboxylesterase 2 -2.13122
GALNS galactosamine (N-acetyl)-6-sulfatase -2.11874
SOAT2 sterol O-acyltransferase 2 -2.10101
TOMM34 translocase of outer mitochondrial membrane 34 -2.09923
ADI1 acireductone dioxygenase 1 -2.09739
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.0681
TCTN1 tectonic family member 1 -2.04457
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.03265
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -2.02722
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.01124
TMBIM1 transmembrane BAX inhibitor motif containing 1 -2.00089