CRCGN014_HEPG2_3H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triprolidine.hcl monohydrate 38.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN014_HEPG2_3H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VGLL4 vestigial-like family member 4 4.0337
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.96999
BZW2 basic leucine zipper and W2 domains 2 3.72082
MSRA methionine sulfoxide reductase A 3.57678
KIF14 kinesin family member 14 3.47965
CBR3 carbonyl reductase 3 3.45154
LAGE3 L antigen family, member 3 3.37485
CXCL2 chemokine (C-X-C motif) ligand 2 3.31887
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.23831
EPHB2 EPH receptor B2 3.09038
CSK c-src tyrosine kinase 2.98612
PRKCH protein kinase C, eta 2.52855
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.49795
GPER1 G protein-coupled estrogen receptor 1 2.43547
CYCS cytochrome c, somatic 2.4269
TBP TATA box binding protein 2.35113
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.28276
ANKMY2 ankyrin repeat and MYND domain containing 2 2.07369
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.05845

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.44389
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.80293
PEG10 paternally expressed 10 -4.19648
PCNA proliferating cell nuclear antigen -3.58051
THAP11 THAP domain containing 11 -3.25436
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.89777
RFC2 replication factor C (activator 1) 2, 40kDa -2.8621
DNM1L dynamin 1-like -2.78666
HMOX1 heme oxygenase 1 -2.34809
PLK1 polo-like kinase 1 -2.33531
CD320 CD320 molecule -2.28217
GOLT1B golgi transport 1B -2.26841
TLR4 toll-like receptor 4 -2.21554
TXNDC9 thioredoxin domain containing 9 -2.20162
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 -2.1539
PLN phospholamban -2.11751
GNAS GNAS complex locus -2.11392
OXA1L oxidase (cytochrome c) assembly 1-like -2.07954
TRAIP TRAF interacting protein -2.03398
POPDC2 popeye domain containing 2 -2.00536
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.00264