CRCGN014_HEPG2_3H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN014_HEPG2_3H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.81661
SNAP25 synaptosomal-associated protein, 25kDa 5.95015
HMOX1 heme oxygenase 1 5.71375
ABHD4 abhydrolase domain containing 4 4.58145
TXNRD1 thioredoxin reductase 1 4.06766
MYLK myosin light chain kinase 3.87652
TREM1 triggering receptor expressed on myeloid cells 1 3.72175
CCP110 centriolar coiled coil protein 110kDa 3.58298
KIF14 kinesin family member 14 3.39209
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.02763
KEAP1 kelch-like ECH-associated protein 1 2.9469
CHMP6 charged multivesicular body protein 6 2.90605
STIMATE STIM activating enhancer 2.82752
NOSIP nitric oxide synthase interacting protein 2.81018
FOSL1 FOS-like antigen 1 2.78716
CYCS cytochrome c, somatic 2.74179
STXBP2 syntaxin binding protein 2 2.72463
ANO1 anoctamin 1, calcium activated chloride channel 2.69701
CSK c-src tyrosine kinase 2.69355
CIAO3 cytosolic iron-sulfur assembly component 3 2.59151
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.35768
GPER1 G protein-coupled estrogen receptor 1 2.32837
GCLM glutamate-cysteine ligase, modifier subunit 2.29238
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.26884
LOC122526780 uncharacterized LOC122526780 2.24189
CCL2 chemokine (C-C motif) ligand 2 2.22842
TUFM Tu translation elongation factor, mitochondrial 2.18659
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.13052
SIRT3 sirtuin 3 2.03259
SQSTM1 sequestosome 1 2.00986
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.00497

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.52063
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.95606
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.67449
TM9SF3 transmembrane 9 superfamily member 3 -3.64412
ADI1 acireductone dioxygenase 1 -3.4984
YME1L1 YME1-like 1 ATPase -2.8706
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.83356
TES testin LIM domain protein -2.51118
TXNDC9 thioredoxin domain containing 9 -2.36171
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.25085
EIF5 eukaryotic translation initiation factor 5 -2.12695
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.11727