| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | hexylresorcinol 40.2 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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270 genes differentially expressed following the CRCGN014_HEPG2_3H:E19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 9.55556 |
| DDIT4 | DNA-damage-inducible transcript 4 | 9.30122 |
| EGR1 | early growth response 1 | 7.43611 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 6.70365 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 6.5173 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 5.74262 |
| SHB | Src homology 2 domain containing adaptor protein B | 5.23868 |
| JUN | jun proto-oncogene | 4.74568 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 4.44661 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.2783 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 4.18776 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.0722 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 3.96086 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 3.9144 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 3.83736 |
| PMM2 | phosphomannomutase 2 | 3.83266 |
| ZFP36 | ZFP36 ring finger protein | 3.78561 |
| NOTCH1 | notch 1 | 3.74718 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 3.73654 |
| TERT | telomerase reverse transcriptase | 3.67465 |
| HSPA1A | heat shock 70kDa protein 1A | 3.6188 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 3.6065 |
| IER2 | immediate early response 2 | 3.55699 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.48912 |
| LCN2 | lipocalin 2 | 3.42458 |
| ICAM1 | intercellular adhesion molecule 1 | 3.39135 |
| HYOU1 | hypoxia up-regulated 1 | 3.33986 |
| CBR1 | carbonyl reductase 1 | 3.31715 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.23402 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 3.16071 |
| GOLT1B | golgi transport 1B | 3.1307 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.12779 |
| MOK | MOK protein kinase | 3.12697 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 3.07606 |
| EPHB2 | EPH receptor B2 | 3.07303 |
| CREB1 | cAMP responsive element binding protein 1 | 3.06444 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 3.06169 |
| ATF3 | activating transcription factor 3 | 3.01221 |
| CBR3 | carbonyl reductase 3 | 2.95941 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.95615 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.94369 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.85828 |
| ATP11B | ATPase, class VI, type 11B | 2.84886 |
| SEC24B | SEC24 family member B | 2.81882 |
| TRIB3 | tribbles pseudokinase 3 | 2.80902 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 2.79168 |
| CAPN1 | calpain 1, (mu/I) large subunit | 2.78339 |
| FICD | FIC domain containing | 2.77443 |
| TRIM13 | tripartite motif containing 13 | 2.75268 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 2.74599 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.74507 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.73358 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.70361 |
| UBQLN2 | ubiquilin 2 | 2.68078 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.66349 |
| ADRB2 | adrenoceptor beta 2, surface | 2.64236 |
| CTSD | cathepsin D | 2.63034 |
| GATA3 | GATA binding protein 3 | 2.62582 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 2.62381 |
| TBC1D15 | TBC1 domain family, member 15 | 2.60934 |
| LIN37 | lin-37 DREAM MuvB core complex component | 2.60222 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.5695 |
| GHR | growth hormone receptor | 2.54144 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.5394 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.52535 |
| IER5 | immediate early response 5 | 2.4955 |
| EGF | epidermal growth factor | 2.46794 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.46613 |
| TRAPPC11 | trafficking protein particle complex 11 | 2.4441 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 2.44033 |
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 2.43369 |
| PRKCD | protein kinase C, delta | 2.42702 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.42375 |
| LOC128125814 | uncharacterized LOC128125814 | 2.42358 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | 2.42214 |
| NVL | nuclear VCP-like | 2.39432 |
| BARX1 | BARX homeobox 1 | 2.38969 |
| PER1 | period circadian clock 1 | 2.3554 |
| CLDN7 | claudin 7 | 2.35421 |
| OPLAH | 5-oxoprolinase (ATP-hydrolysing) | 2.35297 |
| CCDC85B | coiled-coil domain containing 85B | 2.34463 |
| KIFBP | kinesin family binding protein | 2.32788 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 2.32663 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 2.3266 |
| ZNF623 | zinc finger protein 623 | 2.32074 |
| ZBTB48 | zinc finger and BTB domain containing 48 | 2.31296 |
| PLPP6 | phospholipid phosphatase 6 | 2.30751 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 2.29442 |
| DENND1B | DENN/MADD domain containing 1B | 2.2797 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 2.2691 |
| TULP3 | tubby like protein 3 | 2.26116 |
| TESK2 | testis-specific kinase 2 | 2.25219 |
| AVPI1 | arginine vasopressin-induced 1 | 2.24981 |
| SMIM40 | small integral membrane protein 40 | 2.24014 |
| IL1B | interleukin 1, beta | 2.22671 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 2.20209 |
| RTN2 | reticulon 2 | 2.19562 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.1809 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | 2.17571 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.17281 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 2.16264 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.16146 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.15469 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.14905 |
| H1-0 | H1.0 linker histone | 2.14866 |
| EPN3 | epsin 3 | 2.14749 |
| TFPI2 | tissue factor pathway inhibitor 2 | 2.14385 |
| PRKX | protein kinase, X-linked | 2.14001 |
| ZNF34 | zinc finger protein 34 | 2.13644 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 2.13163 |
| FOSL1 | FOS-like antigen 1 | 2.13034 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 2.1289 |
| ODR4 | odr-4 GPCR localization factor homolog | 2.12068 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 2.11114 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.10807 |
| ZNF148 | zinc finger protein 148 | 2.10782 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 2.10514 |
| EDN1 | endothelin 1 | 2.09984 |
| PELO | pelota homolog (Drosophila) | 2.09325 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 2.09056 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2.08731 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | 2.0865 |
| PDE9A | phosphodiesterase 9A | 2.08029 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.06975 |
| H1-10 | H1.10 linker histone | 2.06461 |
| CAMTA2 | calmodulin binding transcription activator 2 | 2.06331 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 2.06256 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 2.05055 |
| NAB2 | NGFI-A binding protein 2 (EGR1 binding protein 2) | 2.03919 |
| H2BC3 | H2B clustered histone 3 | 2.03845 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.03822 |
| STAG3 | stromal antigen 3 | 2.03691 |
| RGPD1 | RANBP2-like and GRIP domain containing 1 | 2.03174 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 2.02667 |
| CCNG2 | cyclin G2 | 2.02499 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 2.02286 |
| MEAK7 | MTOR associated protein, eak-7 homolog | 2.00099 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -6.30248 |
| ZNF586 | zinc finger protein 586 | -6.01125 |
| TLR4 | toll-like receptor 4 | -5.59412 |
| GNAS | GNAS complex locus | -5.54196 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -5.16993 |
| SLC35F2 | solute carrier family 35, member F2 | -5.14114 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -4.9779 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -4.95913 |
| CD320 | CD320 molecule | -4.84948 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.7699 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.29282 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -4.03027 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.98173 |
| HAT1 | histone acetyltransferase 1 | -3.97107 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.96252 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | -3.95237 |
| NUP93 | nucleoporin 93kDa | -3.86254 |
| ISOC1 | isochorismatase domain containing 1 | -3.83677 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -3.82596 |
| TXNDC9 | thioredoxin domain containing 9 | -3.81288 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -3.78081 |
| LBR | lamin B receptor | -3.75025 |
| CRYZ | crystallin, zeta (quinone reductase) | -3.72368 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -3.43511 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -3.35127 |
| PROS1 | protein S (alpha) | -3.3187 |
| BLCAP | bladder cancer associated protein | -3.28548 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | -3.28439 |
| MACF1 | microtubule-actin crosslinking factor 1 | -3.26137 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.23263 |
| MAT2A | methionine adenosyltransferase II, alpha | -3.2283 |
| TBX2 | T-box 2 | -3.10603 |
| TFF2 | trefoil factor 2 | -2.976 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -2.94726 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | -2.92392 |
| GLOD4 | glyoxalase domain containing 4 | -2.89876 |
| WDR7 | WD repeat domain 7 | -2.8811 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.85836 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.7612 |
| CDC20 | cell division cycle 20 | -2.72036 |
| GAA | glucosidase, alpha; acid | -2.70628 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -2.69559 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -2.69473 |
| ETV4 | ets variant 4 | -2.68101 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -2.6484 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.63094 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -2.59097 |
| TCTN1 | tectonic family member 1 | -2.5841 |
| CLTB | clathrin, light chain B | -2.57976 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.56767 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -2.54043 |
| FZD7 | frizzled class receptor 7 | -2.5207 |
| XPO6 | exportin 6 | -2.47883 |
| GALE | UDP-galactose-4-epimerase | -2.47693 |
| CTSV | cathepsin V | -2.4621 |
| STK25 | serine/threonine kinase 25 | -2.45308 |
| PLIN3 | perilipin 3 | -2.43966 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | -2.42573 |
| FASTKD5 | FAST kinase domains 5 | -2.4026 |
| CHEK1 | checkpoint kinase 1 | -2.40102 |
| IGF2R | insulin-like growth factor 2 receptor | -2.39474 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.39165 |
| LGMN | legumain | -2.38052 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -2.37928 |
| FXN | frataxin | -2.37662 |
| TLCD3A | TLC domain containing 3A | -2.36071 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | -2.34366 |
| SCCPDH | saccharopine dehydrogenase (putative) | -2.34332 |
| LASP1 | LIM and SH3 protein 1 | -2.31497 |
| INTS3 | integrator complex subunit 3 | -2.31282 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | -2.31171 |
| CCL11 | chemokine (C-C motif) ligand 11 | -2.30783 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.29399 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -2.28811 |
| NAE1 | NEDD8 activating enzyme E1 subunit 1 | -2.27632 |
| TIMCC | TIM double twin CX3C motif chaperone | -2.26641 |
| NISCH | nischarin | -2.26335 |
| BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor | -2.25777 |
| GTF2H5 | general transcription factor IIH, polypeptide 5 | -2.25397 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -2.25222 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -2.24078 |
| KIF15 | kinesin family member 15 | -2.22683 |
| DPPA4 | developmental pluripotency associated 4 | -2.2111 |
| SORT1 | sortilin 1 | -2.20574 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | -2.19803 |
| CTSE | cathepsin E | -2.19287 |
| C4BPB | complement component 4 binding protein, beta | -2.18317 |
| COG7 | component of oligomeric golgi complex 7 | -2.17974 |
| SEPTIN6 | septin 6 | -2.1748 |
| PLXNC1 | plexin C1 | -2.1735 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -2.1721 |
| VPS4B | vacuolar protein sorting 4 homolog B (S. cerevisiae) | -2.16886 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.15384 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.1505 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -2.14619 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.14356 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -2.1406 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -2.14035 |
| NPAS2 | neuronal PAS domain protein 2 | -2.13716 |
| CYTH1 | cytohesin 1 | -2.13382 |
| HMG20B | high mobility group 20B | -2.13189 |
| PGM1 | phosphoglucomutase 1 | -2.13103 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | -2.12675 |
| PYGL | phosphorylase, glycogen, liver | -2.12384 |
| MBNL3 | muscleblind-like splicing regulator 3 | -2.11581 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -2.11018 |
| TM4SF1 | transmembrane 4 L six family member 1 | -2.10947 |
| VAT1 | vesicle amine transport 1 | -2.09941 |
| VILL | villin-like | -2.09338 |
| SLIRP | SRA stem-loop interacting RNA binding protein | -2.08656 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | -2.08575 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -2.07267 |
| SPAG7 | sperm associated antigen 7 | -2.07017 |
| WDR77 | WD repeat domain 77 | -2.06559 |
| TOR1AIP1 | torsin A interacting protein 1 | -2.05819 |
| TRAK1 | trafficking protein, kinesin binding 1 | -2.05791 |
| ASF1B | anti-silencing function 1B histone chaperone | -2.05696 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.05551 |
| ANAPC1 | anaphase promoting complex subunit 1 | -2.0544 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.04923 |
| NUDC | nudC nuclear distribution protein | -2.04724 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -2.0453 |
| MCOLN1 | mucolipin 1 | -2.04277 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -2.04031 |
| EFHD2 | EF-hand domain family, member D2 | -2.03569 |
| EML4 | echinoderm microtubule associated protein like 4 | -2.03468 |
| CLTC | clathrin, heavy chain (Hc) | -2.03183 |
| PCNA | proliferating cell nuclear antigen | -2.02998 |
| MRGBP | MRG/MORF4L binding protein | -2.02729 |
| CCP110 | centriolar coiled coil protein 110kDa | -2.02006 |
| RPL39 | ribosomal protein L39 | -2.01499 |
| FAM216A | family with sequence similarity 216, member A | -2.00449 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -2.00311 |
