CRCGN014_HEPG2_3H:F06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylene thiourea 39.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN014_HEPG2_3H:F06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 9.2112
MAP7 microtubule-associated protein 7 6.71318
FAIM Fas apoptotic inhibitory molecule 4.93493
SFTPB surfactant protein B 4.93415
BZW2 basic leucine zipper and W2 domains 2 4.92754
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.49376
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.39058
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.17553
GATA3 GATA binding protein 3 4.12049
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.96307
MYLK myosin light chain kinase 3.94664
PRKCH protein kinase C, eta 3.73894
PTK2 protein tyrosine kinase 2 3.53222
SKIC8 SKI8 subunit of superkiller complex 3.33457
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.18843
SHB Src homology 2 domain containing adaptor protein B 2.94949
GPER1 G protein-coupled estrogen receptor 1 2.63804
IDE insulin-degrading enzyme 2.35031
BMP4 bone morphogenetic protein 4 2.28761
NOSIP nitric oxide synthase interacting protein 2.26546
EFCC1 EF-hand and coiled-coil domain containing 1 2.2112
DIPK1A divergent protein kinase domain 1A 2.19643
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.1935
THEM6 thioesterase superfamily member 6 2.19171
AQP3 aquaporin 3 (Gill blood group) 2.15193
ZNF750 zinc finger protein 750 2.13088
TACR2 tachykinin receptor 2 2.11515
ANO2 anoctamin 2, calcium activated chloride channel 2.02749
WNT7A wingless-type MMTV integration site family, member 7A 2.00906

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -5.53369
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.48494
ZNF586 zinc finger protein 586 -4.81084
PLK1 polo-like kinase 1 -4.44934
PRPF4 pre-mRNA processing factor 4 -4.3633
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.68978
CCNB2 cyclin B2 -3.55009
TBC1D31 TBC1 domain family, member 31 -3.50304
TLR4 toll-like receptor 4 -3.41033
GLOD4 glyoxalase domain containing 4 -3.07972
RGS2 regulator of G-protein signaling 2 -2.59213
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.538
NVL nuclear VCP-like -2.4687
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.31632
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -2.31192
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.10287
TXNDC9 thioredoxin domain containing 9 -2.06501