CRCGN014_HEPG2_3H:F07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN014_HEPG2_3H:F07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 5.89771
CXCL2 chemokine (C-X-C motif) ligand 2 4.74394
PPARG peroxisome proliferator-activated receptor gamma 4.5293
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.47829
TCEA2 transcription elongation factor A (SII), 2 4.37092
ADRB2 adrenoceptor beta 2, surface 4.33864
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.02258
TMEM109 transmembrane protein 109 3.99423
RPL39L ribosomal protein L39-like 3.9718
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.94744
PEX11A peroxisomal biogenesis factor 11 alpha 3.64001
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.63994
AXIN1 axin 1 3.59853
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.48231
RPP38 ribonuclease P/MRP 38kDa subunit 3.37596
PLSCR1 phospholipid scramblase 1 3.30495
CSK c-src tyrosine kinase 3.19723
SFTPB surfactant protein B 3.15157
GPER1 G protein-coupled estrogen receptor 1 2.98445
MAP7 microtubule-associated protein 7 2.89505
SYNGAP1 synaptic Ras GTPase activating protein 1 2.62551
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.48846
CEP57 centrosomal protein 57kDa 2.45648
GPATCH8 G patch domain containing 8 2.42431
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.40794
ARID4B AT rich interactive domain 4B (RBP1-like) 2.20376

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.56829
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -4.54512
ISOC1 isochorismatase domain containing 1 -4.31435
TRIB3 tribbles pseudokinase 3 -3.71231
EIF5 eukaryotic translation initiation factor 5 -3.54741
LOC124907782 dual specificity protein phosphatase 22 -3.43228
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.67055
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.66475
BPHL biphenyl hydrolase-like (serine hydrolase) -2.5513
SOAT2 sterol O-acyltransferase 2 -2.43793
RGS2 regulator of G-protein signaling 2 -2.39533
NVL nuclear VCP-like -2.34324
OXA1L oxidase (cytochrome c) assembly 1-like -2.30138
NRIP1 nuclear receptor interacting protein 1 -2.11103
SMC4 structural maintenance of chromosomes 4 -2.05477
EGF epidermal growth factor -2.0154