CRCGN014_HEPG2_3H:F09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexanone 41.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN014_HEPG2_3H:F09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.5063
LCN2 lipocalin 2 5.95013
UBQLN2 ubiquilin 2 5.24096
BACE2 beta-site APP-cleaving enzyme 2 5.1379
LAGE3 L antigen family, member 3 4.7888
PPARG peroxisome proliferator-activated receptor gamma 4.59678
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.53324
GSTZ1 glutathione S-transferase zeta 1 4.23708
SNAP25 synaptosomal-associated protein, 25kDa 4.15224
INTS3 integrator complex subunit 3 3.51284
GPATCH8 G patch domain containing 8 3.4157
RXYLT1 ribitol xylosyltransferase 1 3.31986
SLC75A1 solute carrier family 75 member 1 3.2031
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.04362
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.93416
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.82353
GPER1 G protein-coupled estrogen receptor 1 2.77038
EGF epidermal growth factor 2.7566
CCNF cyclin F 2.68771
LOC124906748 beta-defensin 4A 2.67676
TIAM1 T-cell lymphoma invasion and metastasis 1 2.57048
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.40484
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 2.40227
CHN1 chimerin 1 2.3649
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 2.35787
KRT2 keratin 2, type II 2.2341
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.22848
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.18663
NLRX1 NLR family member X1 2.18207
PLA2G3 phospholipase A2, group III 2.16082
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.15017
CD40 CD40 molecule, TNF receptor superfamily member 5 2.14264
CTSL cathepsin L 2.14228
TGM5 transglutaminase 5 2.10174
HLA-DRA major histocompatibility complex, class II, DR alpha 2.07974
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.07176
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.0629
BTG1 B-cell translocation gene 1, anti-proliferative 2.05272
NPFFR1 neuropeptide FF receptor 1 2.04771
TSC22D4 TSC22 domain family, member 4 2.0394
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.03644
APOD apolipoprotein D 2.02599
SCCPDH saccharopine dehydrogenase (putative) 2.01886

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.86927
OXA1L oxidase (cytochrome c) assembly 1-like -6.38482
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.33891
NT5DC2 5'-nucleotidase domain containing 2 -5.25913
TLR4 toll-like receptor 4 -4.99951
CCNB2 cyclin B2 -4.25002
LDHD lactate dehydrogenase D -3.7133
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.69286
PCCB propionyl CoA carboxylase, beta polypeptide -3.65125
GNAS GNAS complex locus -3.56957
PCNA proliferating cell nuclear antigen -3.33574
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.33484
CCNB1 cyclin B1 -3.15574
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.01842
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.8401
SOAT2 sterol O-acyltransferase 2 -2.73297
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.72615
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.28718
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.10941
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.07795
CHEK1 checkpoint kinase 1 -2.06097
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.03985
FXN frataxin -2.02237
RBM34 RNA binding motif protein 34 -2.0019