CRCGN014_HEPG2_3H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl (z)-2-(dimethylamino)-n-((methylcarbamoyl)oxy)-2-oxoethanimidothioate 20.07 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN014_HEPG2_3H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.76714
BACE2 beta-site APP-cleaving enzyme 2 5.0528
STIMATE STIM activating enhancer 4.94723
CYCS cytochrome c, somatic 4.84353
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.58219
CSK c-src tyrosine kinase 4.3961
MAP7 microtubule-associated protein 7 3.72054
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.63226
CHN1 chimerin 1 3.43423
GPATCH8 G patch domain containing 8 3.3205
AMDHD2 amidohydrolase domain containing 2 3.24468
VAV3 vav 3 guanine nucleotide exchange factor 3.19865
GARRE1 granule associated Rac and RHOG effector 1 2.72049
TBXA2R thromboxane A2 receptor 2.59652
TBP TATA box binding protein 2.56476
HLA-DRA major histocompatibility complex, class II, DR alpha 2.53256
TPD52L2 tumor protein D52-like 2 2.49295
FTO fat mass and obesity associated 2.22857
CDC45 cell division cycle 45 2.18289
TEX10 testis expressed 10 2.09756
COQ3 coenzyme Q3 methyltransferase 2.0871
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.08147
CCL2 chemokine (C-C motif) ligand 2 2.07107
SOCS2 suppressor of cytokine signaling 2 2.06136
FKBP14 FK506 binding protein 14, 22 kDa 2.04554

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -6.64734
VAT1 vesicle amine transport 1 -4.70676
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.68109
WASHC4 WASH complex subunit 4 -4.13825
SLC35F2 solute carrier family 35, member F2 -3.91126
COG2 component of oligomeric golgi complex 2 -3.61556
FBXL12 F-box and leucine-rich repeat protein 12 -3.587
FGFR4 fibroblast growth factor receptor 4 -3.56177
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.28268
CCNB1 cyclin B1 -3.05755
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.03863
OXA1L oxidase (cytochrome c) assembly 1-like -2.4739
PORCN porcupine homolog (Drosophila) -2.07324
INPPL1 inositol polyphosphate phosphatase-like 1 -2.03933